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Emerging Nanotechnology Enabled Theragnostic Approaches in Malignancies and Microbial Infections

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 4917

Special Issue Editors


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Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
Interests: nano(bio)technology; nanomedicine; biomaterials; tissue engineering; cardiovascular regenerative medicine; stem cells; 3D bioprinting; wound healing; drug delivery; antimicrobial materials; hydrogels; electrospun scaffolds; materials science and engineering
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Guest Editor
Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India
Interests: antimicrobial resistance (AMR); antibacterial biomaterials; nano-theragnostic materials for AMR and cancer; biomaterials for cancer therapies; functional nanomaterials for biomedical application
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Guest Editor
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Interests: pharmaceutical biotechnology; nanomedicine; nano-biotechnology; drug delivery for cancer applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoscience and nanotechnology represent a rapidly growing area of research consisting of fields such as pharmacy, chemistry, biology and medicine. Nanomaterials with unique physicochemical properties offer great opportunities and challenges for researchers in biomedical areas. Nanotechnology approaches used in nanomedicine have proved to be an effective alternative for anticancer and antimicrobial treatment options. Cancer and microbial infections can cause dangerous, life-threatening invasive infections and are found to be resistant to a wide range of anticancer drugs and antibiotics, respectively. Notably, multidrug-resistant bacteria represent a major concern in public health as they can destroy the potency of the existing antibiotics. Hence, novel strategies are not only required but are vital to fight against antimicrobial resistance. Meanwhile, nanomedicine plays a pivotal role when it comes to developing alternative and more effective treatment strategies for malignancies and for microbial infections under the abovementioned circumstances.

This Research Topic covers a broad range of nanotechnology-based theragnostic approaches to be used for nanomedicine, biosensing, bioimaging, the biocompatibility of nano-biomaterials, as well as drug delivery systems (including but limited to polymeric nanocomposites, metallic nanocomposites, carbon-based nano systems, nanofibers, and proteins) with the ultimate goal to combat malignancies and microbial infections.

This Topic will focus on the recent and novel findings among scientists and researchers on the developments of emerging nanotechnology-enabled theragnostic approaches for malignancies and microbial infections. We welcome a wide range of submissions, including Original Research, Review, Mini-reviews and Commentaries articles, including but not limited to the following subject matter:

  • Diagnostic and therapeutic applications of a broad range of nano systems, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, metal-based nanoparticles, porphyrin-based nanomaterials, polymeric drug encapsulation delivery systems, self–micro emulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer-drug conjugates, polymeric micelles, and mesoporous silica nanoparticles
  • Synthesis of metal-nanosome clusters and their novel theragnostic applications
  • Targeted drug delivery, drug loading and controlled release of drugs, extracellular vesicles and nanoantibody, nanomaterials for immuno-oncology, active and passive delivery of nanoparticles into cells
  • Tumoral delivery of nanotherapeutics and immune-targeted nanomedicine
  • Use of exosomes in future theragnostic materials and as biomarkers for cancer therapy
  • Multifunctional nanomaterials for targeting cancer nanotheranostics, and nano-based photothermal cancer therapy approaches
  • Green Nanomaterials to Combat Microbial Infection and Cancer

Dr. Ebrahim Mostafavi
Prof. Dr. Muthupandian Saravanan
Dr. Hamed Barabadi
Guest Editors

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Keywords

  • nanomaterials
  • therapeutics
  • diagnostics
  • cancer nanotheranostics
  • antimicrobial

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Published Papers (1 paper)

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Research

17 pages, 4879 KiB  
Article
Exploring the Bioactive Potentials of C60-AgNPs Nano-Composites against Malignancies and Microbial Infections
by Kunal Biswas, Awdhesh Kumar Mishra, Pradipta Ranjan Rauta, Abdullah G. Al-Sehemi, Mehboobali Pannipara, Avik Sett, Amra Bratovcic, Satya Kumar Avula, Tapan Kumar Mohanta, Muthupandian Saravanan and Yugal Kishore Mohanta
Int. J. Mol. Sci. 2022, 23(2), 714; https://doi.org/10.3390/ijms23020714 - 10 Jan 2022
Cited by 8 | Viewed by 3823
Abstract
At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines [...] Read more.
At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs. Furthermore, FTIR revealed the basic vibrational signatures at ~3300 cm−1, 1023 cm−1, 1400 cm−1 for O-H, C-O, and C-H groups, respectively, for the carbon and oxygen atoms of the C60 molecule. NMR studies exhibited the different footprints and magnetic moments at ~7.285 ppm, explaining the unique underlying electrochemical attributes of the fullerene molecule. Such unique electronic and physico-chemical properties of the caged carbon structure raise hope for applications into the drug delivery domain. The in-vitro dose-dependent application of C60 elicits a toxic response against both the breast adenocarcinoma cell lines and pathogenic microbes. That enables the use of AgNPs decorated C60 endo fullerene molecules to design an effective anti-cancerous drug delivery and antimicrobial agent in the future, bringing a revolutionary change in the perspective of a treatment regime. Full article
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