The Cell Biology and Immunology of Wound Healing
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 47258
Special Issue Editors
Interests: cell migration; cytokine secretion; inflammation; tissue repair; wound healing; macrophages; intracellular trafficking; MMP secretion
Interests: nano(bio)technology; nanomedicine; biomaterials; tissue engineering; cardiovascular regenerative medicine; stem cells; 3D bioprinting; wound healing; drug delivery; antimicrobial materials; hydrogels; electrospun scaffolds; materials science and engineering
Special Issues, Collections and Topics in MDPI journals
Interests: tissue injury; repair; inflammation; kidney; wound healing; signaling
Special Issues, Collections and Topics in MDPI journals
Interests: wound healing; cytoskeleton; inflammation; stem cell therapy; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Wound healing is a dynamic process consisting of a complex series of co-ordinated events that work quickly to restore the skin’s protective barrier. This requires the concerted efforts of often distinct but interlinked processes and includes processes such as coagulation, migration, initiation of an inflammatory response, proliferation, regeneration and extracellular matrix (ECM) remodelling. These events must occur in the proper sequence, in a specific time frame and for a precise amount of time for an effective repair process to occur. Numerous cell types in and surrounding the injured skin work together with immune cells that are recruited to the site of injury to orchestrate this repair process. Their sequential and often overlapping actions occur over the course of seconds to months, depending on their precise roles in the repair process, with their numerous molecules, molecular signalling pathways and cues in the extracellular matrix directing how and when wounds heal.
The normal repair process can be dysregulated by changes in these cells that alter the outcome of wound healing. Additionally, other factors, such as age, bacterial infection or maybe be an underlying co-morbidity like diabetes, can alter cellular function, especially immune cell function and inflammation in wounds. This can have a major impact, particularly in areas such as scar formation and alterations in the time it takes for a wound to heal. Our knowledge in these areas is ever expanding as new mechanisms come to light.
This Special Issue of Cells will highlight the cell biology and immunology of wound healing in a collection of original research articles, reviews, and communications. Topics include the physiological and pathophysiological roles that cells in the site of injury or their components released into the wound environment and signalling pathways have on the outcomes of wound healing.
Dr. Rachael Z Murray
Dr. Ebrahim Mostafavi
Dr. Pei-Hui Lin
Prof. Dr. Allison Cowin
Dr. Brooke Farrugia
Guest Editors
Manuscript Submission Information
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Keywords
- wound
- immune cell
- inflammation
- tissue repair
- skin
- macrophage
- neutrophil
- mast cell
- T cell
- dendritic cell
- extracellular matrix
- signalling pathway
- cytokine
- growth factor
- keratinocyte
- fibroblast
- scarring
- ulcer
- chronic wound
- fibrosis
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