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Progress in Synthesis and Application of Heterocycles in Medicinal Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1979

Special Issue Editor


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Guest Editor
Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China
Interests: supramolecular chemistry; host–guest chemistry; macrocycle; self-assembly; supramolecular coordination complex; supramolecular theranostics; supramolecular catalysis; supramolecular separation

Special Issue Information

Dear Colleagues,

Heterocyclic compounds play an important role in drug discovery and drug design. Innovative advances in heterocyclic syntheses help speed up the drug discovery program. The application of heterocycles offers a useful approach for modifying the pharmacological activities of biologically active compounds to optimize the performance of drugs. As medicinal chemistry is a subject that uses chemical concepts and methods to discover, confirm and develop drugs, and study the way and mechanism of their modes of action at the molecular level, this Special Issue will focus on the latest innovations related to heterocycles, especially the research progress in synthesis and application of heterocycles in medicinal chemistry.

Considering your contribution to this interesting research field, I would like to invite you to submit an article to this Special Issue. Full research papers, communications, and review articles are welcome.

Prof. Dr. Jiong Zhou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • supramolecular chemistry
  • heterocycles
  • synthesis
  • application
  • drug discovery
  • drug design
  • biomaterials
  • medicinal chemistry

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Published Papers (1 paper)

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Research

9 pages, 2584 KiB  
Communication
Polyacrylamide-Based Block Copolymer Bearing Pyridine Groups Shows Unexpected Salt-Induced LCST Behavior
by Yunyun Tu, Dandan Fang, Wanli Zhan, Zengming Wei, Liming Yang, Penghui Shao, Xubiao Luo and Guang Yang
Molecules 2023, 28(7), 2921; https://doi.org/10.3390/molecules28072921 - 24 Mar 2023
Cited by 1 | Viewed by 1626
Abstract
Thermal-responsive block copolymers are a special type of macromolecule that exhibit a wide range of applications in various fields. In this contribution, we report a new type of polyacrylamide-based block copolymer bearing pyridine groups of polyethylene glycol-block-poly(N-(2-methylpyridine)-acrylamide; Px) that display distinct [...] Read more.
Thermal-responsive block copolymers are a special type of macromolecule that exhibit a wide range of applications in various fields. In this contribution, we report a new type of polyacrylamide-based block copolymer bearing pyridine groups of polyethylene glycol-block-poly(N-(2-methylpyridine)-acrylamide; Px) that display distinct salt-induced lower critical solution temperature (LCST) behavior. Unexpectedly, the phase-transition mechanism of the salt-induced LCST behavior of Px block copolymers is different from that of the reported LCST-featured analogues. Moreover, their thermo-responsive behavior can be significantly regulated by several parameters such as salt species and concentration, urea, polymerization degree, polymer concentration and pH values. This unique thermal behavior of pyridine-containing block copolymers provides a new avenue for the fabrication of smart polymer materials with potential applications in biomedicine. Full article
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