Bioactive Compounds in Natural Products: Extraction, Analysis and In Vitro Studies
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4585
Special Issue Editors
Interests: analytical chemistry; food quality; phytochemicals; phenolic compounds; bioacessibility; bioavailability; bioactivity
Interests: natural bioactives; bioactivity; cell-based assays; human intervention studies; anticancer effect
Special Issues, Collections and Topics in MDPI journals
Interests: waste valorization; deep eutectic solvents; pressurized co2 extraction; microwave-assisted extraction; natural bioactives
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural products are an important source of bioactive compounds. The diversity of molecules as well as their varying concentration and bioactivity make this study a real challenge.
The methodologies used to extract the different families of bioactive compounds must be chosen according to the characteristics of the matrices under study and the compounds to be evaluated. Moreover, the methodologies used for chemical characterization purposes must be carefully chosen based on sensitivity and selectivity criteria.
In recent years, there has been great development in the procedures used for extraction, characterization, and the evaluation of in vitro bioactivity.
Environmentally friendly and efficient strategies should be developed for the recovery of bioactive compounds from natural matrices. Solid–liquid extraction methods using alternative solvents, such as deep eutectic or pressurized solvents, as well as intensified extractions (e.g., microwaves or ultrasounds assisted), have recently been described.
Advances in sample preparation methodologies, as well as separation techniques, detection modes, and mass spectrometry, have contributed to important advances in the characterization of new molecules and their quantitation in different matrices.
In vitro studies are essential tools to elucidate the possible human-health-promoting effects of natural bioactive compounds. Bioactivity studies range from chemical assays, enzymatic methods, and cell-based assays. More recently, the use of 3D cell models has been applied using advanced analytical tools (omics) in the food and nutrition field to unveil the mechanisms of action of bioactive compounds in health/disease.
Alternative processes of extraction, applications describing new approaches or methodologies to improve the quality of results, recent advances in sample characterization, and applications describing new methodologies to evaluate bioactivity are welcome in this Special Issue.
Dr. Maria Rosário Bronze
Dr. Teresa Serra
Guest Editors
Dr. Naiara Fernández
Guest Editor Assistant
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Keywords
- bioactive
- extraction
- characterization
- bioactivity
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