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Bioactive Compounds in Metabolic Syndrome Tug-of-War

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 3341

Special Issue Editors


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Guest Editor
Graduate School of Regional Innovation Studies, Mie University, Tsu 514-8507, Mie, Japan
Interests: obesity; diabetes; metabolic syndrome; natural product; zebrafish; molecular biology; pharmacology; drug screening
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
Interests: zebrafish; pharmacology; obesity; cancer; natural product; chemical screening
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a clustering of risk factors, including abdominal obesity, hypertriglyceridemia, low HDL levels, hyperglycemia, and hypertension. People who have three or more of these risk factors will be diagnosed with metabolic syndrome. This serious health condition could directly increase the prevalence of cardiovascular disease (CVD), type 2 diabetes mellitus, and stroke. Over the past 40 years, the prevalence of metabolic syndrome has significantly boosted with the parallel of the increasing global epidemic of obesity. Healthy lifestyle interventions are recommended to fight metabolic syndrome, such as increasing physical activity, eating healthy food, and maintaining the proper body weight. Bioactive compound intake is another choice that is expected to prevent or treat metabolic syndrome.

Therefore, this Special Issue in Molecules focuses on the Tug-of-War of bioactive compounds combat to metabolic syndrome, including but not limited to:

  • New bioactive compounds discovery and the related molecular mechanism research on metabolic syndrome and the related disease, including obesity, diabetes, CVD, and stroke
  • Bioactive compounds work on inflammation, carcinogenesis, gut microbiota, body-brain crosstalk focusing on obesity and brain function, etc.
  • Methodology for optimizing bioactive compounds discovery.

We welcome the researchers to share their findings in this field, both in the form of original research or review articles.

Prof. Dr. Liqing Zang
Prof. Dr. Yasuhito Shimada
Guest Editors

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Keywords

  • natural products
  • bioactive compounds
  • metabolic syndrome
  • obesity
  • diabetes
  • cardiovascular disease
  • human health
  • model animals

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Published Papers (1 paper)

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Research

17 pages, 4236 KiB  
Article
Anti-Inflammatory Effect of Ethanolic Extract from Tabebuia rosea (Bertol.) DC., Quercetin, and Anti-Obesity Drugs in Adipose Tissue in Wistar Rats with Diet-Induced Obesity
by Alejandro Barrios-Nolasco, Aarón Domínguez-López, Angel Miliar-García, Jorge Cornejo-Garrido and María Eugenia Jaramillo-Flores
Molecules 2023, 28(9), 3801; https://doi.org/10.3390/molecules28093801 - 28 Apr 2023
Cited by 4 | Viewed by 2675
Abstract
Obesity is characterized by the excessive accumulation of fat, which triggers a low-grade chronic inflammatory process. Currently, the search for compounds with anti-obesogenic effects that help reduce body weight, as well as associated comorbidities, continues. Among this group of compounds are plant extracts [...] Read more.
Obesity is characterized by the excessive accumulation of fat, which triggers a low-grade chronic inflammatory process. Currently, the search for compounds with anti-obesogenic effects that help reduce body weight, as well as associated comorbidities, continues. Among this group of compounds are plant extracts and flavonoids with a great diversity of action mechanisms associated with their beneficial effects, such as anti-inflammatory effects and/or as signaling molecules. In the bark of Tabebuia rosea tree, there are different classes of metabolites with anti-inflammatory properties, such as quercetin. Therefore, the present work studied the effect of the ethanolic extract of T. rosea and quercetin on the mRNA of inflammation markers in obesity compared to the drugs currently used. Total RNA was extracted from epididymal adipose tissue of high-fat diet-induced obese Wistar rats treated with orlistat, phentermine, T. rosea extract, and quercetin. The rats treated with T. rosea and quercetin showed 36 and 31% reductions in body weight compared to the obese control, and they likewise inhibited pro-inflammatory molecules: Il6, Il1b, Il18, Lep, Hif1a, and Nfkb1 without modifying the expression of Socs1 and Socs3. Additionally, only T. rosea overexpressed Lipe. Both T. rosea and quercetin led to a reduction in the expression of pro-inflammatory genes, modifying signaling pathways, which led to the regulation of the obesity-inflammation state. Full article
(This article belongs to the Special Issue Bioactive Compounds in Metabolic Syndrome Tug-of-War)
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