Old Drugs for New Metal-Related Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 23373
Special Issue Editors
Interests: medicinal chemistry and bioinorganic chemistry; analytical chemistry applied in medicine and biology
Interests: The research group of Professor Mariusz Jaremko is focused on understanding and describing the basic principles of protein folding and misfolding, as well as the behavior of peptides and intrinsically disordered proteins (IDPs) under different conditions, including conditions as close as possible to the physiological ones. To achieve these scientific goals, state-of-the-art techniques of biomolecular NMR spectroscopy, together with other biophysical tools, are used. Understanding the biological phenomena which rule protein folding and dynamics would allow for the design of new safe and biodegradable materials with desired physicochemical properties, as well as the rational design of new drugs and efficient therapies against numerous neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, and other protein aggregation-related diseases, like diabetes type II.
Special Issue Information
Dear Colleagues,
Among all known metal ions, several are essential for human life. Others are toxic for humans, even if they are used in medicine. Although the biochemistry of metal ions dates to the previous century, it remains an open field for research projects. As an inseparable part of metal biochemistry, metal ion chelators accompany metal ions as they leave (when in excess) or enter the body (when insufficient). Metal complexes can be used for diagnostics in vitro and in vivo, for metal biopathway studies, or even to kill pathological cells. Different genetic diseases are caused by metal excess or insufficiency: for example, in beta-thalassemia, Wilson’s and Menkes’ diseases. In recent years, further pathologies have been related to metal ions, such as amyloid diseases, neurodegeneration and diabetes. Finally, metal pollution of the environment leads to metal intoxication of humans and animals.
The current costly and time-consuming paradigm of drug discovery is inefficient in combatting rapidly emerging metal-related diseases. Cost, time, and safety are the reasons to revisit existing drugs.
This Special Issue aims to bring together recent research and experience on metal–drug coordination studies, innovative techniques in metal–drug investigations, and drug reposition studies for metal-related diseases. We invite researchers to contribute original research and review articles on recent advances and applications in this field of drug repositioning for metal-related diseases that is receiving so much attention in medicinal chemistry.
Dr. Joanna Izabela Lachowicz
Prof. Dr. Mariusz Jaremko
Dr. Pierpaolo Coni
Guest Editors
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Keywords
- Metal–drug interactions
- Drug repositioning/redirecting
- Metal related diseases
- Metal toxicity
- Bioinorganic chemistry
- Medicinal chemistry
- Chelation therapy
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