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Novel Green Catalysts and Applications of Organocatalysis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 5087

Special Issue Editor

Department of Chemistry, School of Science, Tianjin University, Tianjin, China
Interests: organocatalysis; green reactions; heterogeneous catalysis; cooperative catalysis; organic polymer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Small organic molecules have been used as catalysts in organic and inorganic transformations for a long time. Especially since proline and imidazolidinone were employed to efficiently catalyze asymmetric reactions as the milestones, organocatalysts have been given much more attention. With even better performance than enzymes, organocatalysts may overcome some of the drawbacks of enzymes and metal catalysts, which means that they are sometimes more practical in the chemical industry.

This Special Issue is established to collect new developments on chemical transformations via organocatalysis. This involves but is not limited to research work and reviews on small organic molecule catalysts and their immobilized heterogeneous counterparts. The manuscripts could also be related to transition metal-free organic materials with catalytic activity, such as organic macromolecules/polymers, carbon-based materials, covalent organic frameworks (COFs), and other organic nanomaterials. Moreover, comparisons of organocatalysts with metal and/or enzyme catalysts are welcome in this issue.

Dr. Ning Ma
Guest Editor

Manuscript Submission Information

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Keywords

  • organocatalysis
  • green reactions
  • asymmetric synthesis
  • heterogeneous catalysis
  • transition metal-free catalysts
  • catalytically active organic materials

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Published Papers (3 papers)

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Research

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12 pages, 3168 KiB  
Article
Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach
by Yuliang Hu, Jinping Bao, Dongyu Tang, Shushan Gao, Fei Wang, Zhongtao Ding and Chengsen Cui
Molecules 2024, 29(6), 1328; https://doi.org/10.3390/molecules29061328 - 16 Mar 2024
Cited by 1 | Viewed by 1695
Abstract
(R)-Homobenzylic amines are key structural motifs present in (R)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective [...] Read more.
(R)-Homobenzylic amines are key structural motifs present in (R)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective biocatalytic reductive amination as the key step. The imine reductase IR36-M5 mutant showed high conversion (97%) and stereoselectivity (97%) toward the phenylacetone and propargyl amine substrates, offering valuable biocatalysts for synthesizing alkylated homobenzylic amines. Full article
(This article belongs to the Special Issue Novel Green Catalysts and Applications of Organocatalysis)
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12 pages, 3095 KiB  
Article
Visible Light-Mediated Organoboron-Catalyzed Metal-Free Synthesis of Silanols from Silanes
by Jinbo Yang, Xiangxue Cao, Lanfeng Wei, Jianshu Zhang, Jinli Zhang, Ping Liu, Liang Xu and Pengfei Li
Molecules 2023, 28(10), 4082; https://doi.org/10.3390/molecules28104082 - 13 May 2023
Cited by 3 | Viewed by 1869
Abstract
Herein, a four-coordinated organoboron compound, aminoquinoline diarylboron (AQDAB), is utilized as the photocatalyst in the oxidation of silane to silanol. This strategy effectively oxidizes Si–H bonds, affording Si–O bonds. Generally, the corresponding silanols can be obtained in moderate to good yields at room [...] Read more.
Herein, a four-coordinated organoboron compound, aminoquinoline diarylboron (AQDAB), is utilized as the photocatalyst in the oxidation of silane to silanol. This strategy effectively oxidizes Si–H bonds, affording Si–O bonds. Generally, the corresponding silanols can be obtained in moderate to good yields at room temperature under oxygen atmospheres, representing a green protocol to complement the existing preparation methods for silanols. Full article
(This article belongs to the Special Issue Novel Green Catalysts and Applications of Organocatalysis)
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Review

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20 pages, 5279 KiB  
Review
DNA Catalysis: Design, Function, and Optimization
by Rebecca L. Stratton, Bishal Pokhrel, Bryce Smith, Adeola Adeyemi, Ananta Dhakal and Hao Shen
Molecules 2024, 29(21), 5011; https://doi.org/10.3390/molecules29215011 - 23 Oct 2024
Viewed by 1049
Abstract
Catalytic DNA has gained significant attention in recent decades as a highly efficient and tunable catalyst, thanks to its flexible structures, exceptional specificity, and ease of optimization. Despite being composed of just four monomers, DNA’s complex conformational intricacies enable a wide range of [...] Read more.
Catalytic DNA has gained significant attention in recent decades as a highly efficient and tunable catalyst, thanks to its flexible structures, exceptional specificity, and ease of optimization. Despite being composed of just four monomers, DNA’s complex conformational intricacies enable a wide range of nuanced functions, including scaffolding, electrocatalysis, enantioselectivity, and mechano-electro spin coupling. DNA catalysts, ranging from traditional DNAzymes to innovative DNAzyme hybrids, highlight the remarkable potential of DNA in catalysis. Recent advancements in spectroscopic techniques have deepened our mechanistic understanding of catalytic DNA, paving the way for rational structural optimization. This review will summarize the latest studies on the performance and optimization of traditional DNAzymes and provide an in-depth analysis of DNAzyme hybrid catalysts and their unique and promising properties. Full article
(This article belongs to the Special Issue Novel Green Catalysts and Applications of Organocatalysis)
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