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Enhanced Bioapplications of Biomolecules Mediated by Nanomaterials

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 947

Special Issue Editors


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Guest Editor
Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation & Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China
Interests: bioanalytical chemistry; biomedical diagnostics; biosensors; nano-functional materials; micro/nanochips; bioenergy materials
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Guest Editor
Department of Chemistry and Bioscience, Aalborg University, DK-9220 Aalborg East, Denmark
Interests: molecularly imprinted conjugated molecules; molecular recognition; photonic crystals; organic photovoltaic materials; biosensing materials

Special Issue Information

Dear Colleagues,

Nanomaterials have revolutionized various fields, including biomolecules research and applications. Biomolecules such as proteins, nucleic acids, carbohydrates, and lipids form the basis of the chemistry of life. Using nanomaterials with biomolecules has led to significant advancements in diagnostics, therapeutics, and bioengineering. There are increasing applications of biomolecules in nanomaterials, with the study of related basic theory on optoelectronic chemistry developed quickly. In drug delivery, gold, silver, and magnetic nanoparticles can be conjugated with drugs or used as carriers to deliver therapeutic biomolecules like proteins and nucleic acids to targeted cells with enhanced efficacy and reduced side effects. In clinic diagnostics, quantum dots and fluorescent nanoparticles can be attached to antibodies or other biomolecules for high-resolution imaging and sensitive detection of diseases. Nanomaterials such as carbon nanotubes or graphene can be integrated into biosensors to detect the presence of specific biomolecules, which is useful for diagnosing diseases. Especially, the quantum dots can be used to label and trace specific biomolecules within living cells, providing insights into cellular processes. This Special Issue will focus on the best contributions from a wide community of scientists to challenge and develop novel nanomaterials for biotarget molecules in drug delivery, disease diagnosis, tissue engineering, immunotherapy, and bioenergy processes. We invite both original research articles and review papers to be submitted for consideration.

Prof. Dr. Zhong Cao
Dr. Donghong Yu
Guest Editors

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Keywords

  • nanofunctional materials
  • biomolecular recognition
  • molecular probes
  • biosensors
  • micro/nano chips
  • organic optoelectronic materials
  • bioenergy materials

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Published Papers (1 paper)

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Research

22 pages, 17212 KiB  
Article
Preparation, Evaluation, and Bioinformatics Study of Hyaluronic Acid-Modified Ginsenoside Rb1 Self-Assembled Nanoparticles for Treating Cardiovascular Diseases
by Lixin Du, Yifei Xiao, Qidong Wei, Zhihua Guo and Ya Li
Molecules 2024, 29(18), 4425; https://doi.org/10.3390/molecules29184425 - 18 Sep 2024
Viewed by 818
Abstract
(1) Objective: To optimize the preparation process of hyaluronic acid-modified ginsenoside Rb1 self-assembled nanoparticles (HA@GRb1@CS NPs), characterize and evaluate them in vitro, and investigate the mechanism of action of HA@GRb1@CS NPs in treating cardiovascular diseases (CVDs) associated with inflammation and oxidative stress. (2) [...] Read more.
(1) Objective: To optimize the preparation process of hyaluronic acid-modified ginsenoside Rb1 self-assembled nanoparticles (HA@GRb1@CS NPs), characterize and evaluate them in vitro, and investigate the mechanism of action of HA@GRb1@CS NPs in treating cardiovascular diseases (CVDs) associated with inflammation and oxidative stress. (2) Methods: The optimal preparation process was screened through Plackett–Burman and Box–Behnken designs. Physical characterization of HA@GRb1@CS NPs was conducted using transmission electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry. Stability experiments, in vitro drug release studies, and lyophilisate selection were performed to evaluate the in vitro performance of HA@GRb1@CS NPs. The anti-inflammatory and antioxidant capabilities of HA@GRb1@CS NPs were assessed using H9c2 and RAW264.7 cells. Additionally, bioinformatics tools were employed to explore the mechanism of action of HA@GRb1@CS NPs in the treatment of CVDs associated with inflammation and oxidative stress. (3) Results: The optimal preparation process for HA@GRb1@CS NPs was achieved with a CS concentration of 2 mg/mL, a TPP concentration of 2.3 mg/mL, and a CS to TPP mass concentration ratio of 1.5:1, resulting in a particle size of 126.4 nm, a zeta potential of 36.8 mV, and a PDI of 0.243. Characterization studies confirmed successful encapsulation of the drug within the carrier, indicating successful preparation of HA@GRb1@CS NPs. In vitro evaluations demonstrated that HA@GRb1@CS NPs exhibited sustained-release effects, leading to reduced MDA (Malondialdehyde) content and increased SOD (Superoxide Dismutase) content in oxidatively damaged H9c2 cells. Furthermore, it showed enhanced DPPH (2,2-Diphenyl-1-picrylhydrazyl) and ABTS+ [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] free radical scavenging rates and inhibited the release of inflammatory factors NO (Nitric Oxide) and IL-6 (Interleukin-6) from RAW264.7 cells. (4) Conclusions: The HA@GRb1@CS NPs prepared in this study exhibit favorable properties with stable quality and significant anti-inflammatory and antioxidant capabilities. The mechanisms underlying their therapeutic effects on CVDs may involve targeting STAT3, JUN, EGFR, CASP3, and other pathways regulating cell apoptosis, autophagy, anti-lipid, and arterial sclerosis signaling pathways. Full article
(This article belongs to the Special Issue Enhanced Bioapplications of Biomolecules Mediated by Nanomaterials)
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