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Discovery of Microbial Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 842

Special Issue Editors


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Guest Editor
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: streptomyces; actinomycetes; amycolatopsis; natural products; secondary metabolites; bioactive compounds

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Guest Editor
Department of Chemistry and Nano Science, College of Natural Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea
Interests: marine natural products; structure elucidation of natural products; antibacterial and anti-cancer natural products
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Special Issue Information

Dear Colleagues,

There is a rich variety of microorganism species, and the number of cultured microorganisms is estimated to only account for about 10% of all microorganisms on Earth. These small organisms produce novel chemical structures that are not found in plants and organisms capable of movement. Microbial natural products have displayed a diversity of compounds, leading to the discovery of drug candidates with beneficial biological activities. 

In recent years, advances in biotechnology, such as the activation of various biosynthetic gene clusters (BGCs) which had remained silent for decades, have enabled the production of novel compounds from microorganisms. Our objective is to focus on the discovery of structurally and biologically novel microbial compounds and their potential in drug development. As the Guest Editors of this Special Issue, we welcome high-quality reviews or research articles on topics including, but not limited to, the following: microbial natural products; structural determination; microorganisms; drug candidates; bioactive secondary metabolites; and microbial biotechnology.

Prof. Dr. Yun Kwon
Dr. Sang-Jip Nam
Guest Editors

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Keywords

  • microbial natural products
  • determination of structure
  • microorganism
  • drug candidate
  • bioactive secondary metabolites
  • microbial biotechnology

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Published Papers (1 paper)

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Research

10 pages, 1665 KiB  
Article
Three New Depsipeptides, Homiamides A–C, Isolated from Streptomyces sp., ROA-065
by Jeong-Hyeon Kim, Ji Young Lee, Juri Lee, Prima F. Hillman, Jihye Lee, Byeongchan Choi, Man-Jeong Paik, Songyi Lee and Sang-Jip Nam
Molecules 2024, 29(23), 5539; https://doi.org/10.3390/molecules29235539 - 23 Nov 2024
Viewed by 691
Abstract
Three new depsipeptides, homiamides A–C (13), were isolated from a marine sediment-derived strain of Streptomyces sp., ROA-065. The planar structures of homiamides A–C (13) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) [...] Read more.
Three new depsipeptides, homiamides A–C (13), were isolated from a marine sediment-derived strain of Streptomyces sp., ROA-065. The planar structures of homiamides A–C (13) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of 13 were deduced from the application of the Marfey’s method and GC-MS analysis after formation of the O-trifluoroacetylated (S)-(+)-methyl-2-butyl ester derivatives of amino acids. Compounds 13 exhibited weak anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria, with compound 1 showing MIC values of 32–64 μg/mL. In antifouling assays, compounds 1 and 2 displayed moderate activity against Micrococcus luteus KCTC 3063, while compound 3 exhibited weak activity against all tested bacteria. Full article
(This article belongs to the Special Issue Discovery of Microbial Natural Products)
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