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Analytical Chemistry in Clinical Studies and PET Developments

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 4394

Special Issue Editors


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Guest Editor
1. MedSolutions Stockholm, Sweden
2. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, SE-171 76 Stockholm, Sweden
Interests: drug research; bioanalysis; sampling and sample preparation for biological samples; mass spectrometry; liquid and gas chromatography
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Karolinska Institutet, Stockholm, Sweden
Interests: PET radioligands; neuroimaging; molecular imaging; Imaging biomarkers for Parkinson and Alzheimer

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Guest Editor
Karolinska Institutet, Stockholm, Sweden
Interests: radiometabolite analysis; protein binding measurement; mass spectrometry; liquid chromatography; sample preparation and bioanalysis

Special Issue Information

Dear Colleagues,

This Issue will handle radiometabolite analysis concept and the importance of the sample preparation and separation techniques such as LC-MS aid in radiometabolite analysis. The issue will deal with the challenges in PET application and in radiometabolite analysis.

Prof. Mohamed Abdel Rehim
Prof. Christer Halldin
Dr. Mohammad Mahdi Moein
Guest Editors

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Keywords

  • Mass Spectrometry
  • Sample Preparation
  • Bioanalysis
  • PET (positron emission tomography)
  • Radiometabolites Analysis
  • Protein Binding
  • Non-human primate
  • Blood and Plasma matrices
  • Carbon11
  • Fluorine18
  • Molecular Imaging
  • Neuroimaging
  • Liquid Chromatography

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Published Papers (1 paper)

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Research

14 pages, 2450 KiB  
Article
Preclinical Evaluation of Radiolabeled Peptides for PET Imaging of Glioblastoma Multiforme
by Zbynek Novy, Jana Stepankova, Michaela Hola, Dominika Flasarova, Miroslav Popper and Milos Petrik
Molecules 2019, 24(13), 2496; https://doi.org/10.3390/molecules24132496 - 8 Jul 2019
Cited by 17 | Viewed by 3802
Abstract
In this study, we have compared four 68Ga-labeled peptides (three Arg-Gly-Asp (RGD) peptides and substance-P) with two 18F-tracers clinically approved for tumor imaging. We have studied in vitro and in vivo characteristics of selected radiolabeled tracers in a glioblastoma multiforme tumor [...] Read more.
In this study, we have compared four 68Ga-labeled peptides (three Arg-Gly-Asp (RGD) peptides and substance-P) with two 18F-tracers clinically approved for tumor imaging. We have studied in vitro and in vivo characteristics of selected radiolabeled tracers in a glioblastoma multiforme tumor model. The in vitro part of the study was mainly focused on the evaluation of radiotracers stability under various conditions. We have also determined in vivo stability of studied 68Ga-radiotracers by analysis of murine urine collected at various time points after injection. The in vivo behavior of tested 68Ga-peptides was evaluated through ex vivo biodistribution studies and PET/CT imaging. The obtained data were compared with clinically used 18F-tracers. 68Ga-RGD peptides showed better imaging properties compared to 18F-tracers, i.e., higher tumor/background ratios and no accumulation in non-target organs except for excretory organs. Full article
(This article belongs to the Special Issue Analytical Chemistry in Clinical Studies and PET Developments)
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