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Phytochemistry, Human Health and Molecular Mechanisms
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Phytochemistry, Human Health and Molecular Mechanisms

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 5639

Special Issue Editors

Prof. Dr. Valeria Naponelli

E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
Interests: autophagy; cancer; epigallocatechin gallate; polyphenol; flavanols; White Tea; antioxidant; extract
Prof. Dr. Elena Ferrari

E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
Interests: metabolomics; catechins; metabolism in health and disease; allergenic proteins; protein structure

Special Issue Information

Dear Colleague,

The Section of Molecules entitled “Phytochemistry, Human Health and Molecular Mechanisms” aims to publish high-quality scientific contributions that provide novel insights into the impact of plant components, also known as phytochemicals, on human health. We welcome submissions with novel data on phytochemical bioaccessibility, bioavailability, absorption, metabolism, and bioactivity. Additionally, we are interested in stimulating debate on (facilitating conversations about) their effects on microbiota, their mechanisms of action, their improved formulation, and their safety of use as a food ingredient or additive. We will give special consideration to studies on the role of phytochemicals in key physiological functions and in the pathogenesis of human diseases. In addition, epidemiological studies that seek to identify the relationship between dietary intake of phytochemicals and the risk of disease also fall within the scope of this Section.

Both original research articles and comprehensive reviews are eligible for inclusion.

Prof. Dr. Valeria Naponelli
Prof. Dr. Elena Ferrari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • bioavailability
  • extraction methods
  • biological activities
  • functional applications
  • nutraceuticals
  • human metabolism
  • toxicity
  • bioactive-gut microbiota relationships

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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14 pages, 3056 KiB  
Article
Comparative Studies of Bioactivities and Chemical Components in Fresh and Black Garlics
by Kanako Matsuse, Sho Hirata, Mostafa Abdelrahman, Tetsuya Nakajima, Yoshihito Iuchi, Satoshi Kambayashi, Masaru Okuda, Kimiko Kazumura, Benya Manochai and Masayoshi Shigyo
Molecules 2024, 29(10), 2258; https://doi.org/10.3390/molecules29102258 - 11 May 2024
Cited by 2 | Viewed by 2489
Abstract
To investigate the bioactivities of fresh garlic and its processed product, black garlic, we conducted comparative analyses of antioxidant, anti-inflammatory, innate immune activation, and anti-cancer activities in addition to the chemical composition (sugar, amino acid, and polyphenol contents) of these materials. Simultaneous assay [...] Read more.
To investigate the bioactivities of fresh garlic and its processed product, black garlic, we conducted comparative analyses of antioxidant, anti-inflammatory, innate immune activation, and anti-cancer activities in addition to the chemical composition (sugar, amino acid, and polyphenol contents) of these materials. Simultaneous assay using neutrophil-like cells showed that fresh garlic exhibited antioxidant and innate immunostimulatory activities, whereas black garlic displayed a potent anti-inflammatory effect. The antioxidant activity index was correlated with phenol and flavonoid contents, while the innate immunostimulatory activity was correlated with fructan content. Furthermore, some black garlics with low fructose content were found to inhibit the proliferation of UM-UC-3 cancer cells, while other black garlics rich in fructose increased UM-UC-3 cell proliferation. It was shown that the processing of fresh garlic could change the composition of sugars, antioxidants, and amino acids, which have different effects on neutrophil-like cells and UM-UC-3 cells, as well as on bioactivities. Full article
(This article belongs to the Special Issue Phytochemistry, Human Health and Molecular Mechanisms)
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13 pages, 1440 KiB  
Article
Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata
by Qu-Jing Luo, Wen-Chao Zhou, Xin-Yi Liu, Ya-Jie Li, Qing-Ling Xie, Bin Wang, Chao Liu, Wen-Mao Wang, Wei Wang and Xu-Dong Zhou
Molecules 2023, 28(24), 7956; https://doi.org/10.3390/molecules28247956 - 5 Dec 2023
Cited by 4 | Viewed by 1466
Abstract
Ampelopsis grossedentata is a valuable medicinal and edible plant, which is often used as a traditional tea by the Tujia people in China. A. grossedentata has numerous biological activities and is now widely used in the pharmaceutical and food industries. In this study, [...] Read more.
Ampelopsis grossedentata is a valuable medicinal and edible plant, which is often used as a traditional tea by the Tujia people in China. A. grossedentata has numerous biological activities and is now widely used in the pharmaceutical and food industries. In this study, two new flavonoids (1–2) and seventeen known compounds (3–19) were isolated and identified from the dried stems and leaves of A. grossedentata. These isolated compounds were characterized by various spectroscopic data including mass spectrometry and nuclear magnetic resonance spectroscopy. All isolates were assessed for their α-glucosidase inhibitory, antioxidant, and hepatoprotective activities, and their structure–activity relationships were further discussed. The results indicated that compound 1 exhibited effective inhibitory activity against α-glucosidase, with an IC50 value of 0.21 μM. In addition, compounds 1–2 demonstrated not only potent antioxidant activities but also superior hepatoprotective properties. The findings of this study could serve as a reference for the development of A. grossedentata-derived products or drugs aimed at realizing their antidiabetic, antioxidant, and hepatoprotective functions. Full article
(This article belongs to the Special Issue Phytochemistry, Human Health and Molecular Mechanisms)
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Review

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16 pages, 262 KiB  
Review
The Chemical Residues in Secondary Beekeeping Products of Environmental Origin
by Joanna Wojtacka
Molecules 2024, 29(16), 3968; https://doi.org/10.3390/molecules29163968 - 22 Aug 2024
Viewed by 749
Abstract
Natural products of bee origin, despite their complex composition and difficulties in standardization, have been of high interest among scientists representing various disciplines from basic sciences to industrial and practical implementation. As long as their use is monitored and they do not impact [...] Read more.
Natural products of bee origin, despite their complex composition and difficulties in standardization, have been of high interest among scientists representing various disciplines from basic sciences to industrial and practical implementation. As long as their use is monitored and they do not impact human health, they can be considered valuable sources of many chemical compounds and are potentially useful in medicine, food processing, nutrition, etc. However, apart from honey, the general turnover of bee products lacks precise and detailed legal requirements ensuring their quality. The different residues in these products constitute a problem, which has been reported in numerous studies. All products derived from beekeeping are made by bees, but they are also influenced by the environment. Such a dual pathway requires detailed surveillance of hazards stemming from outside and inside the apiary. This should be ensured via harmonized requirements arising from the binding legal acts, especially in international and intercontinental trade zones. Full article
(This article belongs to the Special Issue Phytochemistry, Human Health and Molecular Mechanisms)
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