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Featured Review Papers in Bioorganic Chemistry 2024
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Featured Review Papers in Bioorganic Chemistry 2024

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 12268

Special Issue Editors

Prof. Dr. Naresh Kumar

E-Mail Website
Guest Editor
School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
Interests: biologically active molecules; medicinal chemistry; organic chemical synthesis; peptidomimetics; novel antimicrobials; biomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Maja Jazvinšćak Jembrek

E-Mail Website
Guest Editor
1. Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
2. School of Medicine, Catholic University of Croatia, 10000 Zagreb, Croatia
Interests: neuroprotection; neurotoxicity; neurodegenerative diseases; oxidative stress; polyphenols; neuropharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Molecules is seeking contributions reviewing any area of research in bioorganic chemistry that has a broad appeal and is positioned within the scope of the Journal. The summaries of the most recent, innovative developments in bioorganic chemistry are welcome. Topics of interest include but are not limited to:

  • enzyme inhibitors
  • enzyme immobilization & controlled enzyme immobilization
  • biocatalysis (ribozymes & catalytic antibodies)
  • biosynthesis
  • immunochemical techniques
  • membrane chemistry
  • protein and small biomolecules
  • peptides chemistry
  • biopolymers and artificial supramolecular assemblies
  • molecular recognition of nucleic acids
  • bioactive lipids
  • non-natural amino acids
  • mass spectrometry studies on biomolecules
  • bioactive peptides and proteins
  • biological signalling

We kindly invite and encourage all research groups covering various bioorganic chemistry areas to submit contributions to this Special Issue.

Prof. Dr. Naresh Kumar
Dr. Maja Jazvinšćak Jembrek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioorganic chemistry
  • enzyme inhibitors
  • biocatalysis
  • biosynthesis
  • immunochemical techniques
  • membrane chemistry
  • peptides chemistry

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Review

31 pages, 2559 KiB  
Review
Roles of Post-Translational Modifications of Transcription Factors Involved in Breast Cancer Hypoxia
by Logan Seymour, Niyogushima Nuru, Kaya R. Johnson, Jennifer Michel Villalpando Gutierrez, Victor Tochukwu Njoku, Costel C. Darie and Anca-Narcisa Neagu
Molecules 2025, 30(3), 645; https://doi.org/10.3390/molecules30030645 - 1 Feb 2025
Viewed by 443
Abstract
BC is the most commonly diagnosed cancer and the second leading cause of cancer death among women worldwide. Cellular stress is a condition that leads to disrupted homeostasis by extrinsic and intrinsic factors. Among other stressors, hypoxia is a driving force for breast [...] Read more.
BC is the most commonly diagnosed cancer and the second leading cause of cancer death among women worldwide. Cellular stress is a condition that leads to disrupted homeostasis by extrinsic and intrinsic factors. Among other stressors, hypoxia is a driving force for breast cancer (BC) progression and a general hallmark of solid tumors. Thus, intratumoral hypoxia is an important determinant of invasion, metastasis, treatment failure, prognosis, and patient mortality. Acquisition of the epithelial–mesenchymal transition (EMT) phenotype is also a consequence of tumor hypoxia. The cellular response to hypoxia is mainly regulated by the hypoxia signaling pathway, governed by hypoxia-inducible factors (HIFs), mainly HIF1α. HIFs are a family of transcription factors (TFs), which induce the expression of target genes involved in cell survival and proliferation, metabolic reprogramming, angiogenesis, resisting apoptosis, invasion, and metastasis. HIF1α cooperates with a large number of other TFs. In this review, we focused on the crosstalk and cooperation between HIF1α and other TFs involved in the cellular response to hypoxia in BC. We identified a cluster of TFs, proposed as the HIF1α-TF interactome, that orchestrates the transcription of target genes involved in hypoxia, due to their post-translational modifications (PTMs), including phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation, hydroxylation, acetylation, S-nitrosylation, and palmitoylation. PTMs of these HIF1α-related TFs drive their stability and activity, degradation and turnover, and the bidirectional translocation between the cytoplasm or plasma membrane and nucleus of BC cells, as well as the transcription/activation of proteins encoded by oncogenes or inactivation of tumor suppressor target genes. Consequently, PTMs of TFs in the HIF1α interactome are crucial regulatory mechanisms that drive the cellular response to oxygen deprivation in BC cells. Full article
(This article belongs to the Special Issue Featured Review Papers in Bioorganic Chemistry 2024)
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24 pages, 2078 KiB  
Review
Effects of Phenolic Acids Produced from Food-Derived Flavonoids and Amino Acids by the Gut Microbiota on Health and Disease
by Yoshimitsu Kiriyama, Hiroshi Tokumaru, Hisayo Sadamoto, Suguru Kobayashi and Hiromi Nochi
Molecules 2024, 29(21), 5102; https://doi.org/10.3390/molecules29215102 - 29 Oct 2024
Viewed by 1899
Abstract
The gut microbiota metabolizes flavonoids, amino acids, dietary fiber, and other components of foods to produce a variety of gut microbiota-derived metabolites. Flavonoids are the largest group of polyphenols, and approximately 7000 flavonoids have been identified. A variety of phenolic acids are produced [...] Read more.
The gut microbiota metabolizes flavonoids, amino acids, dietary fiber, and other components of foods to produce a variety of gut microbiota-derived metabolites. Flavonoids are the largest group of polyphenols, and approximately 7000 flavonoids have been identified. A variety of phenolic acids are produced from flavonoids and amino acids through metabolic processes by the gut microbiota. Furthermore, these phenolic acids are easily absorbed. Phenolic acids generally represent phenolic compounds with one carboxylic acid group. Gut microbiota-derived phenolic acids have antiviral effects against several viruses, such as SARS-CoV-2 and influenza. Furthermore, phenolic acids influence the immune system by inhibiting the secretion of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α. In the nervous systems, phenolic acids may have protective effects against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Moreover, phenolic acids can improve levels of blood glucose, cholesterols, and triglycerides. Phenolic acids also improve cardiovascular functions, such as blood pressure and atherosclerotic lesions. This review focuses on the current knowledge of the effects of phenolic acids produced from food-derived flavonoids and amino acids by the gut microbiota on health and disease. Full article
(This article belongs to the Special Issue Featured Review Papers in Bioorganic Chemistry 2024)
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18 pages, 1322 KiB  
Review
Zinc Toxicity: Understanding the Limits
by Hannah Schoofs, Joyce Schmit and Lothar Rink
Molecules 2024, 29(13), 3130; https://doi.org/10.3390/molecules29133130 - 1 Jul 2024
Cited by 23 | Viewed by 7119
Abstract
Zinc, a vital trace element, holds significant importance in numerous physiological processes within the body. It participates in over 300 enzymatic reactions, metabolic functions, regulation of gene expression, apoptosis and immune modulation, thereby demonstrating its essential role in maintaining overall health and well-being. [...] Read more.
Zinc, a vital trace element, holds significant importance in numerous physiological processes within the body. It participates in over 300 enzymatic reactions, metabolic functions, regulation of gene expression, apoptosis and immune modulation, thereby demonstrating its essential role in maintaining overall health and well-being. While zinc deficiency is associated with significant health risks, an excess of this trace element can also lead to harmful effects. According to the World Health Organization (WHO), 6.7 to 15 mg per day are referred to be the dietary reference value. An excess of the recommended daily intake may result in symptoms such as anemia, neutropenia and zinc-induced copper deficiency. The European Food Safety Authority (EFSA) defines the tolerable upper intake level (UL) as 25 mg per day, whereas the Food and Drug Administration (FDA) allows 40 mg per day. This review will summarize the current knowledge regarding the calculation of UL and other health risks associated with zinc. For example, zinc intake is not limited to oral consumption; other routes, such as inhalation or topical application, may also pose risks of zinc intoxication. Full article
(This article belongs to the Special Issue Featured Review Papers in Bioorganic Chemistry 2024)
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17 pages, 5374 KiB  
Review
Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone: A Systematic Review
by Renate Viebahn-Haensler and Olga Sonia León Fernández
Molecules 2024, 29(12), 2738; https://doi.org/10.3390/molecules29122738 - 8 Jun 2024
Viewed by 1934
Abstract
Our hypothesis that controlled ozone applications interfere with the redox balance of a biological organism (first published in 1998 with a preclinical trial on protecting the liver from CCl4 intoxication) has been verified over the past two decades in reactive oxygen species [...] Read more.
Our hypothesis that controlled ozone applications interfere with the redox balance of a biological organism (first published in 1998 with a preclinical trial on protecting the liver from CCl4 intoxication) has been verified over the past two decades in reactive oxygen species (ROS)-induced mitochondrial pathologies, such as rheumatoid arthritis, osteoarthritis, aging processes and type 2 diabetes, and in the prevention of intoxications. Low-dose ozone acts as a redox bioregulator: the restoration of the disturbed redox balance is comprehensible in a number of preclinical and clinical studies by a remarkable increase in the antioxidant repair markers, here mainly shown as a glutathione increase and a reduction in oxidative stress markers, mainly malondialdehyde. The mechanism of action is shown, and relevant data are displayed, evaluated and comprehensively discussed: the repair side of the equilibrium increases by 21% up to 140% compared to the non-ozone-treated groups and depending on the indication, the stress markers are simultaneously reduced, and the redox system regains its balance. Full article
(This article belongs to the Special Issue Featured Review Papers in Bioorganic Chemistry 2024)
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