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Advances in Biomaterials for Drug Delivery and Tissue Regeneration
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Advances in Biomaterials for Drug Delivery and Tissue Regeneration

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 17542

Special Issue Editors

Prof. Dr. Rui Guo

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Jinan University, Guangzhou, China
Interests: bioactive materials; nanomedicine technology; bioactive peptide; hydrogel; tissue regeneration
Dr. Gang Wu

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery/Pathology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Interests: bioactive peptide; multifunctional calcium phosphate bone-filling materials; cartilage tissue engineering; cell signaling for osteogenesis; skin wound healing

Special Issue Information

Dear Colleagues,

Tissue regeneration is a multidisciplinary technology that integrates stem cells, scaffolds and bioactive agents to improve or replace biological tissues. Stem cells and scaffolds can be made into tissue engineered implants for the repair of tissue defects. Bioactive agents can be naturally-derived or synthetic cytokines, growth factors, extracellular vesicles, small-molecules and peptides with one or multiple functions such as osteoinduction, osteoconduction, anti-inflammation, anti-cancer and anti-osteoclast. These bioactive agents need to be incorporated by carrier materials and be slowly released to maximize the functionalization efficacy of the tissue engineered implants with an aim to promote defect healing and/or antagonize the influences of adverse conditions.

This Special Issue focuses on advances in biomaterials for drug delivery and tissue regeneration. The topic welcomes, but is not limited to e.g. Original Research, Reviews, Mini Reviews, the following research areas:

  1. Design, development and evaluation of novel bioactive agents and slow system for drug delivery
  2. Advanced control release systems of bioactive agents
  3. The interaction between regenerative microenvironments and the release of bioactive agents
  4. 3D printed functional scaffolds and organelles
  5. Advanced systems based on functional biomaterials and stem cells
  6. Cells-scaffold interactions for tissue regeneration

Prof. Dr. Rui Guo
Dr. Gang Wu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive agents
  • peptides
  • hydrogel
  • stem cells
  • tissue regeneration
  • drug delivery

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Published Papers (5 papers)

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Research

18 pages, 6594 KiB  
Article
Notoginsenoside R1 Promotes Migration, Adhesin, Spreading, and Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stromal Cells
by Haiyan Wang, Yongyong Yan, Haifeng Lan, Nan Wei, Zhichao Zheng, Lihong Wu, Richard T. Jaspers, Gang Wu and Janak L. Pathak
Molecules 2022, 27(11), 3403; https://doi.org/10.3390/molecules27113403 - 25 May 2022
Cited by 6 | Viewed by 2292
Abstract
Cellular activities, such as attachment, spreading, proliferation, migration, and differentiation are indispensable for the success of bone tissue engineering. Mesenchymal stromal cells (MSCs) are the key precursor cells to regenerate bone. Bioactive compounds from natural products had shown bone regenerative potential. Notoginsenoside R1 [...] Read more.
Cellular activities, such as attachment, spreading, proliferation, migration, and differentiation are indispensable for the success of bone tissue engineering. Mesenchymal stromal cells (MSCs) are the key precursor cells to regenerate bone. Bioactive compounds from natural products had shown bone regenerative potential. Notoginsenoside R1 (NGR1) is a primary bioactive natural compound that regulates various biological activities, including cardiovascular protection, neuro-protection, and anti-cancer effects. However, the effect of NGR1 on migration, adhesion, spreading, and osteogenic differentiation of MSCs required for bone tissue engineering application has not been tested properly. In this study, we aimed to analyze the effect of NGR1 on the cellular activities of MSCs. Since human adipose-derived stromal cells (hASCs) are commonly used MSCs for bone tissue engineering, we used hASCs as a model of MSCs. The optimal concentration of 0.05 μg/mL NGR1 was biocompatible and promoted migration and osteogenic differentiation of hASCs. Pro-angiogenic factor VEGF expression was upregulated in NGR1-treated hASCs. NGR1 enhanced the adhesion and spreading of hASCs on the bio-inert glass surface. NGR1 robustly promoted hASCs adhesion and survival in 3D-printed TCP scaffold both in vitro and in vivo. NGR1 mitigated LPS-induced expression of inflammatory markers IL-1β, IL-6, and TNF-α in hASCs as well as inhibited the RANKL/OPG expression ratio. In conclusion, the biocompatible NGR1 promoted the migration, adhesion, spreading, osteogenic differentiation, and anti-inflammatory properties of hASCs. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Drug Delivery and Tissue Regeneration)
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24 pages, 8375 KiB  
Article
Effect of Ionic and Non-Ionic Surfactant on Bovine Serum Albumin Encapsulation and Biological Properties of Emulsion-Electrospun Fibers
by Roksana Kurpanik, Agnieszka Lechowska-Liszka, Joanna Mastalska-Popławska, Marek Nocuń, Alicja Rapacz-Kmita, Anna Ścisłowska-Czarnecka and Ewa Stodolak-Zych
Molecules 2022, 27(10), 3232; https://doi.org/10.3390/molecules27103232 - 18 May 2022
Cited by 11 | Viewed by 2601
Abstract
Emulsion electrospinning is a method of modifying a fibers’ surface and functional properties by encapsulation of the bioactive molecules. In our studies, bovine serum albumin (BSA) played the role of the modifier, and to protect the protein during the electrospinning process, the W/O [...] Read more.
Emulsion electrospinning is a method of modifying a fibers’ surface and functional properties by encapsulation of the bioactive molecules. In our studies, bovine serum albumin (BSA) played the role of the modifier, and to protect the protein during the electrospinning process, the W/O (water-in-oil) emulsions were prepared, consisting of polymer and micelles formed from BSA and anionic (sodium dodecyl sulfate–S) or nonionic (Tween 80–T) surfactant. It was found that the micelle size distribution was strongly dependent on the nature and the amount of the surfactant, indicating that a higher concentration of the surfactant results in a higher tendency to form smaller micelles (4–9 µm for S and 8–13 µm for T). The appearance of anionic surfactant micelles reduced the diameter of the fiber (100–700 nm) and the wettability of the nonwoven surface (up to 77°) compared to un-modified PCL polymer fibers (100–900 nm and 130°). The use of a non-ionic surfactant resulted in better loading efficiency of micelles with albumin (about 90%), lower wettability of the nonwoven fabric (about 25°) and the formation of larger fibers (100–1100 nm). X-ray photoelectron spectroscopy (XPS) was used to detect the presence of the protein, and UV-Vis spectrophotometry was used to determine the loading efficiency and the nature of the release. The results showed that the location of the micelles influenced the release profiles of the protein, and the materials modified with micelles with the nonionic surfactant showed no burst release. The release kinetics was characteristic of the zero-order release model compared to anionic surfactants. The selected surfactant concentrations did not adversely affect the biological properties of fibrous substrates, such as high viability and low cytotoxicity of RAW macrophages 264.7. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Drug Delivery and Tissue Regeneration)
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11 pages, 1012 KiB  
Article
Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents
by Kamran Ahmad Khan, Gul Majid Khan, Muhammad Muzammal, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Maitham A. Al Hawaj, Ashfaq Ahmad, Zahid Rasul Niazi, Kifayat Ullah Shah and Arshad Farid
Molecules 2022, 27(3), 864; https://doi.org/10.3390/molecules27030864 - 27 Jan 2022
Cited by 5 | Viewed by 3381
Abstract
Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were [...] Read more.
Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method was adopted for the preparation of matrices. In phosphate buffer (pH 6.8), the dissolution study was conducted by adopting the USP method-I as the specified method. Drug release kinetics was determined and dissolution profiles were also compared with the reference standard. Prolonged release was observed for all matrices, but those with Ethocel 100FP Premium showed more extended release. The co-excipient (HPMC, CMC, and starch) exhibited enhancement in the drug release rates, while all controlled release matrices released the drug by anamolous non-Fickian diffusion mechanism. This combination of polymers (Ethocel grade 100 with Carbopol 934PNF) efficiently extended the drug release rates up to 24 h. It is suggested that these matrix tablets can be given in once a day dosage, which might improve patient compliance, and the polymeric blend of Ethocel grade 100 with Carbopol 934PNF might be used in the development of prolonged release matrices of other water-soluble drugs. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Drug Delivery and Tissue Regeneration)
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16 pages, 3021 KiB  
Article
K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration?
by Wei Cao, Jianfeng Jin, Gang Wu, Nathalie Bravenboer, Marco N. Helder, Janak L. Pathak, Behrouz Zandieh-Doulabi, Jolanda M. A. Hogervorst, Shingo Matsukawa, Lester C. Geonzon, Rommel G. Bacabac, Engelbert A. J. M. Schulten and Jenneke Klein-Nulend
Molecules 2021, 26(20), 6131; https://doi.org/10.3390/molecules26206131 - 11 Oct 2021
Cited by 20 | Viewed by 3624
Abstract
Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is [...] Read more.
Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (Opn, Dmp1, and Mepe) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Drug Delivery and Tissue Regeneration)
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16 pages, 3780 KiB  
Article
Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
by Xushan Chen, Huimin Zhang, Xin Yang, Wuhong Zhang, Ming Jiang, Ting Wen, Jie Wang, Rui Guo and Hanjiao Liu
Molecules 2021, 26(13), 4037; https://doi.org/10.3390/molecules26134037 - 1 Jul 2021
Cited by 45 | Viewed by 4688
Abstract
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. [...] Read more.
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Drug Delivery and Tissue Regeneration)
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