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Biochemical Aspects of Inflammation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2276

Special Issue Editors

Department of Biochemistry and Molecular Biology, Xi'an Jiaotong University, Xi'an, China
Interests: chronic inflammatory diseases; autoimmunity; asthma; immuno-metabolism; epigenetic regulation
Institute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China
Interests: inflammation; autoimmune diseases; innate immunity; macrophages; T cells
Institute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China
Interests: innate immunity; macrophages; pattern recognition receptor; chitinase and chitinase-like proteins; inflammation

Special Issue Information

Dear Colleagues,

Inflammation is the body's response to exogenous or endogenous attacks and is also considered to be a process of self-protection. Mediators of inflammation and their triggered signalling pathways act together to constitute the network of inflammation, which will eventually cause inflammation-mediated diseases, including but not limited to infection, autoimmune diseases, allergic diseases, and so on.

In recent years, the metabolic reprogramming of immune cells has been found to control the fate of immune cells, thereby governing the process of inflammation. The intermediate metabolic pathways of biomacromolecules including carbohydrates, lipids, and amino acids, as well as other inorganic ions and organic molecules, are indicative of their importance for immune regulation and the inflammatory response. The key enzymes and metabolites of metabolic pathways, as well as the natural and synthetic compounds targeting these biochemical reactions, have been prioritized.

In order to keep up with the cutting-edge research in this field, we are seeking papers on any and all topics relevant to biochemical aspects of inflammation. We are looking forward to receiving your contribution.

Dr. Shemin Lu
Dr. Liesu Meng
Dr. Wenhua Zhu
Guest Editors

Manuscript Submission Information

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Keywords

  • inflammation
  • mediators of inflammation
  • immunometabolism
  • key enzymes
  • metabolites
  • chemical inhibitors

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Published Papers (1 paper)

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Research

17 pages, 4273 KiB  
Article
Resolvin D5 (RvD5) Reduces Renal Damage Caused by LPS Endotoxemia in Female Mice
by Renato D. R. Cardoso, Sandmary D. Chambo, Tiago H. Zaninelli, Beatriz H. S. Bianchini, Matheus Deroco Veloso da Silva, Mariana M. Bertozzi, Telma Saraiva-Santos, Anelise Franciosi, Geovana Martelossi-Cebinelli, Pamela E. Garcia-Miguel, Sergio M. Borghi, Rubia Casagrande and Waldiceu A. Verri
Molecules 2023, 28(1), 121; https://doi.org/10.3390/molecules28010121 - 23 Dec 2022
Cited by 2 | Viewed by 1844
Abstract
In self-revolving gram-negative Escherichia coli infection, Resolvin D5 (RvD5) was found to enhance bacteria phagocytosis and reduce the production of inflammatory mediators, contributing to the resolution of infection. LPS (lipopolysaccharide) is a gram-negative bacterial structure product which activates the immune system and, at [...] Read more.
In self-revolving gram-negative Escherichia coli infection, Resolvin D5 (RvD5) was found to enhance bacteria phagocytosis and reduce the production of inflammatory mediators, contributing to the resolution of infection. LPS (lipopolysaccharide) is a gram-negative bacterial structure product which activates the immune system and, at high doses, leads to endotoxemia. To our knowledge, the effect of RvD5 against LPS endotoxemia has not been investigated to date. Female Swiss mice received an i.p. treatment with RvD5 (0.1, 1 or 10 ng/animal). After 1 h, they were stimulated with LPS (10 mg/kg, i.v.), and samples were collected after additional 6 h. The resulting data demonstrated that RvD5 protected the kidneys (urea and creatinine serum levels) from tissue injury. These effects were related to an improvement in histopathological parameters and a reduction of enzymatic markers of leukocyte infiltration, pro-inflammatory cytokine (IL-1β, TNF-α, and IL-6) production, and oxidative stress. Antioxidant markers were also increased by RvD5, but IL-10 (an anti-inflammatory cytokine) levels were unaltered. We also observed that RvD5 reduced the infiltration of CD45+ hematopoietic cells into the kidneys, reduced the activation of NFκB and promoted the Nrf2 pathway by reducing Keap-1 levels. Our data indicate that RvD5 may be a therapeutic possibility to reduce kidney lesions in LPS endotoxemia. Full article
(This article belongs to the Special Issue Biochemical Aspects of Inflammation)
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