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Dyes and Luminophores as Biomarkers

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Colorants".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 3584

Special Issue Editors


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Guest Editor
Department of Pathology, Kazan State Medical University, Kazan, Russia
Interests: cancer, gastrointestinal stromal tumors (GIST); soft tissue sarcomas (STS); targeted-based therapy; resistance; apoptosis; receptor tyrosine kinase inhibitors (RTKi); DNA damage repair (DDR); FGF-signaling
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Guest Editor
1. Department of General and Organic chemistry, Kazan State Medical University, ul. Butlerova, 49, 420012 Kazan, Russia
2. Kazan (Volga Region) Federal University, ul. Kremlevskaya, 18, 420008 Kazan, Russia
Interests: organic chemistry; synthesis; biological activity; terpenoids

Special Issue Information

Dear Colleagues,

Dyes and luminophores have received much attention over the last two decades as biomarkers, and they are widely believed to have considerable implications for various applied biological and medical research. It is well known that biomarkers based on fluorescent dyes are widely used in diagnosing diseases and tracking their progression. In addition, scientists have always seen biomarkers as a useful mean to visualize and establish the mechanisms of membranotropic activity, localization sites and drug delivery routes, studying biochemical interactions, quantifying metabolites, etc. The aim of the present Special Issue is therefore to shed new light on dyes and luminophores synthesis and ways of their structural modification, their physical and chemical properties fundamental research, as well as new achievements of functionalized biomarkers application in biological and medical fields.

Prof. Dr. Sergei Boichuk
Prof. Dr. Liliya E. Nikitina
Guest Editors

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Keywords

  • luminophores
  • dyes
  • biovisualization
  • biomarkers
  • fluorescence spectroscopy

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Published Papers (1 paper)

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Research

15 pages, 3426 KiB  
Article
Spectroscopic and In Vitro Investigations of Boron(III) Complex with Meso-4-Methoxycarbonylpropylsubstituted Dipyrromethene for Fluorescence Bioimaging Applications
by Galina Guseva, Elena Antina, Mikhail Berezin, Svetlana Lisovskaya, Roman Pavelyev, Airat Kayumov, Olga Lodochnikova, Daut Islamov, Konstantin Usachev, Sergei Boichuk and Liliya Nikitina
Molecules 2020, 25(19), 4541; https://doi.org/10.3390/molecules25194541 - 3 Oct 2020
Cited by 12 | Viewed by 2795
Abstract
This study focuses on the behavior of a new fluorescent marker for labeling individual biomolecules and staining cell organelles developed on a meso-substituted BODIPY platform. Boron(III) complex with meso-4-methoxycarbonylpropylsubstituted 3,3’,5,5’-tetramethyl-2,2′-dipyrromethene has been synthesized and identified via visible, UV-, NMR- and MS-spectra [...] Read more.
This study focuses on the behavior of a new fluorescent marker for labeling individual biomolecules and staining cell organelles developed on a meso-substituted BODIPY platform. Boron(III) complex with meso-4-methoxycarbonylpropylsubstituted 3,3’,5,5’-tetramethyl-2,2′-dipyrromethene has been synthesized and identified via visible, UV-, NMR- and MS-spectra X-ray. The behavior of fluorophore in solutions has been studied with various experimental techniques. It has been found that luminophore exhibits a high quantum yield (almost ~100–75%) in the blue-green region (513–520 nm) and has high photostability. In addition, biological analysis indicates that the fluorophore exhibits a tendency to effectively penetrate into cell membranes. On the other hand, the proposed BODIPY can be used to study the significant differences among a large number of pathogens of mycotic infections, as well as to visualize structural changes in the plasma membrane, which is necessary for the clearance of mammalian cells undergoing apoptotic cell death. Full article
(This article belongs to the Special Issue Dyes and Luminophores as Biomarkers)
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