Proteins and Peptides Self-Assemblies: Synthesis, Structural Elucidation and Functional Properties
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4501
Special Issue Editor
Interests: bio-active peptides; self-assembly peptides; peptide-based conjugates for drug delivery; peptidomimetics; targeting protein–protein interactions; organometallic chemistry in nitrogen-containing heterocycles
Special Issue Information
Dear Colleagues,
The self-assembly of biomolecules is a naturally occurring process in living cells that provides complex superstructures which have a multitude of essential biological functions. At the same time; protein or peptide aggregation and complexation in structures such as fibrils or amyloid oligomers is often related to the development of several diseases for which efficient treatments are still needed. In recent decades; the elucidation of the structural bases that generate these highly ordered; three-dimensional supramolecular assemblies; strongly dependent on specific peptide sequences; was achieved using novel therapeutic agents targeting protein–protein interactions as well as novel peptide-based biomaterials. In this context; the study of self-assembling peptides that aggregate in controllable nanosystems such as fibers; micelles; and gels has recently emerged as an exciting direction of research to fabricate biocompatible systems for drug delivery and tissue engineering. As a consequence; the investigation of protein/peptide self-assembly represents an important field of research; the outcomes of which can offer new opportunities in the fields of drug discovery and biomaterials development.
The purpose of this Special Issue is to collect an interdisciplinary overview of recent progress in the synthesis; structure and functional elucidation of protein and peptide self-assembly in supramolecular functional systems. We invite you to submit contributions in the form of reviews or original research articles that provide new insights into this intriguing research area.
Dr. Silvia Gazzola
Guest Editor
Manuscript Submission Information
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Keywords
- self-assembling peptides
- supramolecular peptide nanostructures
- structure elucidation
- protein self-assembly and aggregation
- computational approaches in the design of self-assembling peptides
- peptide-based functional materials
- targeting protein–protein assemblies and aggregates
- biomolecular vehicles for drug delivery
- nanofibers
- nanotubes and gels
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