Advances in Human Pathogenic Trypanosomatids
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 1648
Special Issue Editor
2. Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay
Interests: Trypanosoma cruzi; Leishmania; genomics; molecular parasitology; Chagas disease; Neospora caninum
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Trypanosomatids are unicellular parasites responsible for several neglected diseases, causing significant morbidity and mortality in millions of people worldwide. For example, Trypanosoma cruzi, African trypanosomes, and Leishmania spp. are responsible for Chagas disease, sleeping sickness, and various forms of leishmaniasis, respectively. These parasites have complex life cycles involving two hosts, one vertebrate and one invertebrate. Additionally, they can infect a wide variety of mammals, leading to both domestic and wild animal disease reservoirs.
Although these parasites share a common ancestor, millions of years of evolution have resulted in significant differences among them. For instance, African trypanosomes are extracellular, while Leishmania and T. cruzi invade cells for their replication, with the former targeting the mononuclear phagocytic system and the latter both professional and non-professional phagocytic cells.
A common trait among these parasites is their ability to persist within their hosts, achieved through various strategies of invasion and immune evasion. These biological characteristics present significant research challenges, necessitating diverse approaches, including the search for drugs and vaccines and understanding their invasion mechanisms, immune system modulation, and gene expression regulation, among others.
This Special Issue focuses on original research contributions and review articles on human pathogenic trypanosomatids, aiming to explore their immunological, cellular, molecular, and biochemical characteristics within the context of host–pathogen interactions and advance our understanding of their biology.
Prof. Dr. Carlos Robello
Guest Editor
Manuscript Submission Information
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Keywords
- trypanosomatids
- Trypanosoma cruzi
- African trypanosomes
- Chagas disease
- sleeping sickness
- Leishmania spp.
- leishmaniasis
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