Recent Advances in Drug Metabolism, Transport, and Pharmacokinetics
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 268
Special Issue Editors
Interests: pharmacodynamics and pharmacokinetics; molecular and clinical pharmacology; pharmacogenetics; PKPD modeling; clinical PKPD studies; clinical pharmacy
Interests: nutritional biochemistry; gynaecology; clinical pharmacology; genetics; pharmacogenetics; osteoporosis; bone; bone mineral density; genotyping; bone metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Medicines approved for use must demonstrate effectiveness and safety. Every drug must be evaluated based on a statistical analysis of clinical studies performed in patient populations. However, in later clinical practice, the percentage of patients responding to the therapy is much lower than what we wished for. The pharmacological response to the drug, including its side effects, is strongly related to its concentration in the target tissue and other organs. The principles of the concentration–effect relationship are the basis of pharmacodynamics (PD), whereas pharmacokinetics (PK) studies the effect of an organism on a drug and describes the time course of drug concentration. Currently, pharmacotherapy favors personalization. We realize that the inter- and intra-individual variability in the clinical response to a drug is high and that many factors contribute to this. Determining the mechanism and kinetics of different processes that the drug undergoes in the body and the factors limiting these processes is challenging. To overcome this challenge, we need advances in the scientific processes related to drug pharmacokinetics to predict the drug disposition in every patient. This Special Issue focuses on this topic. We welcome original research articles, reviews, meta-analyses, and other publication types in this Special Issue titled “Recent Advances in Drug Metabolism, Transport, and Pharmacokinetics”. We are particularly interested in innovative studies that explore new insights and developments in drug metabolism, transport mechanisms, and pharmacokinetic modeling and contributions that address the challenges and opportunities in personalizing pharmacotherapy. This Special Issue will contribute to a deeper understanding of these critical areas and help shape the future of individualized treatment strategies.
Prof. Dr. Agnieszka Bienert
Dr. Joanna Bartkowiak-Wieczorek
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacokinetic analysis
- analytical methods suitable for pharmacokinetics studies
- pharmacogenetics in drug pharmacokinetics
- clinical pharmacokinetics
- drug concentrations in plasma and tissue
- population PK modeling
- drug metabolic pathways
- drug transport across barriers
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