Biomolecules as Drug Candidates for Chronic Inflammation
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2876
Special Issue Editors
2. Institute for Research and Inovation in Health (i3S), University of Porto, 4099-002 Porto, Portugal
Interests: evidence-based medicine; phytochemistry; phytopharmacology; drug discovery; natural products biochemistry; bioactive molecules; functional foods; nutraceuticals; fungal and bacterial infections; resistance to antimicrobials
Special Issues, Collections and Topics in MDPI journals
Interests: drug synthesis; medicinal and aromatic plants; bioactive compounds; heterocyclic chemistry
Special Issue Information
Dear Colleagues,
Inflammation is the body's natural response to cellular dysfunction, healing injuries or stimuli agents by alerting inflammatory cells and cytokines. Among the two categories of inflammation, acute and chronic, chronic inflammation has numerous triggers, and, as a result, chronic diseases can occur, including cancer; cardiovascular, neurodegenerative, and osteoarticular diseases; diabetes; asthma; mood disorders; Parkinson's disease; Alzheimer's disease; dementia; arthritis; and multiple sclerosis; among others.
Recognized as arising from modern society, these chronic diseases have a multifactorial origin, but there is an aspect that is transversal to all—the associated morbimortality and healthcare burden—which has raised serious concerns among the medical and scientific community.
Several studies have been developed in an attempt to clarify the main risk factors that are in its genesis, in developing adequate prevention and monitoring programs, but also in the discovery of increasingly better, more effective and accurate therapeutic regimens. To date, several drugs have been developed for such a purpose; however, more recently, given their ineffectiveness, side effects and toxicity, the interest in the study of medicinal plants and natural products has re-emerged as a source of biomolecules with high therapeutic value, used since time immemorial for the prevention and even treatment of a multitude of physiological conditions. Biomolecules comprise a broad class of highly complex organic compounds with recognized bioactive effects that have been increasingly proposed as a key option for preventing chronic inflammation or even for the treatment of chronic conditions.
In this sense, this Special Issue aims to cover all aspects related to the pathogenesis of chronic inflammation, with particular emphasis on the discovery of new molecules that can help to prevent, reduce or even counteract chronic inflammation and, consequently, be of extreme usefulness in various chronic diseases, also clarifying their mechanisms of action.
Prof. Dr. Natália Cruz-Martins
Dr. Latifa Bouissane
Guest Editors
Manuscript Submission Information
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Keywords
- chronic inflammation
- biomolecules
- mechanisms of action, therapeutic effect
- pharmacokinetics
- pharmacodynamics
- new drugs
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