Orodispersible Tablets: New Advances in Preparation Technologies
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: 24 February 2025 | Viewed by 1397
Special Issue Editors
Interests: orodispersible tablets; minitablets; pediatric formulations; parenteral nutrition
Interests: pharmaceutical technology; biopharmaceutics; artificial intelligence; machine learning; data science
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although orodispersible tablets (ODTs) were introduced to the pharmaceutical market more than 25 years ago, this dosage form still remains a subject of interest for many pharmaceutical technologists as well as innovators from pharma companies. ODTs gain more and more popularity in the pharmacotherapy of many diseases, including both acute and chronic kinds.
The first methods in the production of ODTs involved freeze drying processes, yet nowadays they are mainly produced via direct compression or tableting after granulation. There are two major reasons the application of these methods has been widely used: the development of superdisintegrants, and the introduction of the co-processed excipients with superior compression properties. Both significantly shortened the disintegration process of compressed ODTs, while the latter also improved mechanical properties and facilitated their production.
Recent trends in the development of ODTs include the formulation of the third generation of these tablets, featuring modified release dosage forms, particularly tablets containing microcapsules, coated micropellets or sustained release granules. Their utilization allows for easy administration to pediatric patients or any other persons having difficulties in swallowing solid dosage forms. Other interesting approaches in the formulation of ODTs is the preparation of orodispersible minitablets (ODMTs, MODTs), as well as research into alternative production technologies for these tablets, such as 3D-printing methods.
This Special Issue of Pharmaceuticals invites both reviews and original articles exploring all aspects of orodispersible tablets. Topics of interest include studies on different features of ODTs, beginning from the conceptualization of the innovative forms through to the formulation process and ending on the pharmacokinetics of these forms and clinical trials of new formulations.
Dr. Witold Brniak
Prof. Dr. Aleksander Mendyk
Guest Editors
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Keywords
- orodispersible tablets
- orally disintegrating tablets
- superdisintegrants
- co-processed excipients
- direct compression
- 3D printing
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