Unveiling Nature's Pharmacy: Exploring Drug Discovery Through Medicinal Plants
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 687
Special Issue Editor
Interests: diabetes mellitus; obesity; age-related diseases; advanced glycation end products (AGEs); medicinal plants; enzyme activity; pharmacokinetics; ADMET; pharmacotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There is significant research that is currently underway concerning ethnopharmacology, with the aim of identifying new medicinal plants, new chemical compounds derived from these plants (phytoconstituents), and any new mechanisms by which these compounds exert their biological activity. Indeed, the findings of this research may contribute to the development of new pharmaceutical agents. The concept of polypharmacology is undergoing a significant evolution in response to a novel approach to the utilization of plant-derived products that possess a multitude of phytoconstituents and exhibit multitarget efficacy against specific human diseases. A multitude of signal transduction pathways are implicated in the pathogenesis of non-infectious diseases, including diabetes mellitus, thyroid disease, and neurovascular and degenerative diseases. The main mechanisms involved include glycation reactions, imbalances between free radical production and antioxidant systems, and inflammatory pathways. This Special Issue is an invitation to submit original research and reviews regarding in vitro tests on natural and derived compounds targeting specific cellular pathological mechanisms involved in non-infectious diseases. Specific focus will be placed on novel experimental assay methods and pharmacokinetic evaluations, including in silico approaches. Studies on the ADMET properties of plant-derived preparations and natural compounds are also of significant interest.
Dr. Guglielmina Froldi
Guest Editor
Manuscript Submission Information
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Keywords
- plant-derived drugs
- secondary metabolites
- advanced glycation end-products (AGEs)
- reactive oxygen species (ROS)
- molecular targets
- pharmacokinetics
- ADMET
- bioavailability
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