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Pharmaceuticals
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Biodegradable Polymeric Nanoparticles for Drug Delivery
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Biodegradable Polymeric Nanoparticles for Drug Delivery

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 7170

Special Issue Editors

Dr. Alejandro Manzano-Ramírez

E-Mail Website
Guest Editor
Centro de Investigaciones y de Estudios Avanzados del I.P.N. Unidad Querétaro, Querétaro 76230, Mexico
Interests: metallic nanoparticles; green synthesis; nanoencapsulation; drug delivery; plant extracts
Dr. Karen Magaly Soto Martínez

E-Mail Website
Guest Editor
Centro de Investigaciones y de Estudios Avanzados del I. P. N. Unidad Querétaro, Queretaro 76230, Mexico
Interests: proteins; composite material; material characterization; green synthesis; antimicrobial activity; anticancer compounds

Special Issue Information

Dear Colleagues,

Nanotechnology has begun to play an essential role in biomedical applications, especially smart biodegradable nanostructures used for drug delivery. These structures can release the action in response to specific environmental stimuli, improving its therapeutic effect and protecting it from external factors. The present Special Issue intends to provide an overview of the most novelty polymeric nanostructures developed for drug delivery. We will emphasize primary wall materials, new encapsulation methods, the formation of novel nanostructures, and in vitro and in vivo release tests, in which its effectiveness in protection, smart delivery, and the improvement of bioavailability is verified.

Dr. Alejandro Manzano-Ramírez
Dr. Karen Magaly Soto Martínez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable
  • smart nanostructures
  • drug delivery
  • bioavailability
  • release
  • biopolymers

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Published Papers (3 papers)

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Research

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16 pages, 3735 KiB  
Article
Docetaxel-Loaded Methoxy poly(ethylene glycol)-poly (L-lactic Acid) Nanoparticles for Breast Cancer: Synthesis, Characterization, Method Validation, and Cytotoxicity
by Shumaila Miraj, Hamid Saeed, Mehwish Iqtedar, Norah A. Albekairi, Nadeem Ahmed, Muhammad Zeeshan Danish, Muhammad Islam, Muhammad Fawad Rasool, Kashif Mairaj Deen and Hassaan Anwer Rathore
Pharmaceuticals 2023, 16(11), 1600; https://doi.org/10.3390/ph16111600 - 13 Nov 2023
Cited by 2 | Viewed by 1859
Abstract
This study aimed to synthesize and characterize DTX-mPEG-PLA-NPs along with the development and validation of a simple, accurate, and reproducible method for the determination and quantification of DTX in mPEG-PLA-NPs. The prepared NPs were characterized using AFM, DLS, zetasizer, and drug release kinetic [...] Read more.
This study aimed to synthesize and characterize DTX-mPEG-PLA-NPs along with the development and validation of a simple, accurate, and reproducible method for the determination and quantification of DTX in mPEG-PLA-NPs. The prepared NPs were characterized using AFM, DLS, zetasizer, and drug release kinetic profiling. The RP-HPLC assay was developed for DTX detection. The cytotoxicity and anti-clonogenic effects were estimated using MTT and clonogenic assays, respectively, using both MCF-7 and MDA-MB-231 cell lines in a 2D and 3D culture system. The developed method showed a linear response, high precision, accuracy, RSD values of ≤2%, and a tailing factor ≤2, per ICH guidelines. The DTX-mPEG-PLA-NPs exhibited an average particle size of 264.3 nm with an encapsulation efficiency of 62.22%. The in vitro drug kinetic profile, as per the Krosmeyers–Peppas model, demonstrated Fickian diffusion, with initial biphasic release and a multistep sustained release over 190 h. The MTT assay revealed improved in vitro cytotoxicity against MCF-7 and MDA-MB-231 in the 2D cultures and MCF-7 3D mammosphere cultures. Significant inhibitions of the clonogenic potential of MDA-MB-231 were observed for all concentrations of DTX-mPEG-PLA-NPs. Our results highlight the feasibility of detecting DTX via the robust RP-HPLC method and using DTX-mPEG-PLA-NPs as a perceptible and biocompatible delivery vehicle with greater cytotoxic and anti-clonogenic potential, supporting improved outcomes in BC. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Nanoparticles for Drug Delivery)
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18 pages, 2524 KiB  
Article
Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor
by Itziar Galarreta-Rodriguez, Mikel Etxebeste-Mitxeltorena, Esther Moreno, Daniel Plano, Carmen Sanmartín, Saad Megahed, Neus Feliu, Wolfgang J. Parak, Eneko Garaio, Izaskun Gil de Muro, Luis Lezama, Idoia Ruiz de Larramendi and Maite Insausti
Pharmaceuticals 2023, 16(7), 949; https://doi.org/10.3390/ph16070949 - 30 Jun 2023
Cited by 3 | Viewed by 1864
Abstract
In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored [...] Read more.
In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe3O4 nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe3O4 nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe3O4 nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Nanoparticles for Drug Delivery)
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Review

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15 pages, 2391 KiB  
Review
Asymmetric Lipid Vesicles: Techniques, Applications, and Future Perspectives as an Innovative Drug Delivery System
by Denisse Gardea-Gutiérrez, Eduardo Núñez-García, Berenice E. Oseguera-Guerra, Manuel Román-Aguirre and Silvia L. Montes-Fonseca
Pharmaceuticals 2023, 16(6), 777; https://doi.org/10.3390/ph16060777 - 23 May 2023
Cited by 5 | Viewed by 2931
Abstract
Novel lipid-based nanosystems have been of interest in improving conventional drug release methods. Liposomes are the most studied nanostructures, consisting of lipid bilayers ideal for drug delivery, thanks to their resemblance to the cell plasma membrane. Asymmetric liposomes are vesicles with different lipids [...] Read more.
Novel lipid-based nanosystems have been of interest in improving conventional drug release methods. Liposomes are the most studied nanostructures, consisting of lipid bilayers ideal for drug delivery, thanks to their resemblance to the cell plasma membrane. Asymmetric liposomes are vesicles with different lipids in their inner and outer layers; because of this, they can be configured to be compatible with the therapeutic drug while achieving biocompatibility and stability. Throughout this review, topics such as the applications, advantages, and synthesis techniques of asymmetric liposomes will be discussed. Further, an in silico analysis by computational tools will be examined as a helpful tool for designing and understanding asymmetric liposome mechanisms in pharmaceutical applications. The dual-engineered design of asymmetric liposomes makes them an ideal alternative for transdermal drug delivery because of the improved protection of pharmaceuticals without lowering adsorption rates and system biocompatibility. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Nanoparticles for Drug Delivery)
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