Recent Advances in Psychiatric Medications

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1892

Special Issue Editors


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Guest Editor
Department of Hygiene and Epidemiology, Medical University of Gdansk, Gdansk, Poland
Interests: psychiatric epidemiology; mental health; psychopharmacology; suicidology; digital health

E-Mail Website
Guest Editor
Department of Hygiene and Epidemiology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland
Interests: antipsychotics; epidemiology

Special Issue Information

Dear Colleagues,

According to the World Health Organization (WHO), mental health disorders are widespread, affecting approximately one in eight individuals worldwide. Anxiety disorders and depressive disorders are the most frequently observed conditions in both males and females. Mental illnesses are the primary contributor to years lived with disabilities (YLDs), representing one sixth of all YLDs worldwide.

Today, psychiatric drugs are one of the most important treatment options for people suffering in this way. In fact, the introduction of psychiatric medications was one of the biggest breakthroughs in the history of the treatment of mental disorders. It significantly contributed to a shift in the treatment paradigm from long-term hospitalization to therapy in the patient's community settings. Having been improved over a number of years, today, psychiatric medications are the evidence-based gold standard for treating the majority of mental disorders.

At the same time, there is still a need for further research into their application in areas that have so far received little coverage, e.g., substance-misuse disorders, dementia, autism spectrum disorders, personality disorders, etc. The use of psychiatric drugs has also been criticized from a number of legitimate perspectives regarding their significant side effects, the potential abuse of certain substances, the related abandonment of other treatments (such as psychotherapy), or even the relegation of important individual and social problems to the simple and relatively inexpensive solution of taking a pill.

This Special Issue aims to highlight cutting-edge research, innovative approaches, and emerging trends in the development, efficacy, safety, utilization, and limitations of psychiatric medications.

I look forward to your valuable contributions.

Dr. Przemyslaw Waszak
Prof. Dr. Paweł Zagożdżon
Guest Editors

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Keywords

  • mental health treatment
  • psychopharmacology
  • antidepressants
  • antipsychotics
  • side effects
  • safety profiles
  • treatment resistance
  • adherence issues

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Published Papers (1 paper)

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Review

17 pages, 640 KiB  
Review
Haloperidol for Pain Management: A Narrative Review
by Carlos J. Roldan, Jonathan W. Rowland and Alice L. Ye
Pharmaceuticals 2024, 17(8), 1096; https://doi.org/10.3390/ph17081096 - 21 Aug 2024
Viewed by 1284
Abstract
The use of haloperidol in pain management has been a topic of interest for several decades. Haloperidol is a widely used antipsychotic medication with unique pharmacologic properties that make it a potential candidate for pain management. However, the efficacy and safety of haloperidol [...] Read more.
The use of haloperidol in pain management has been a topic of interest for several decades. Haloperidol is a widely used antipsychotic medication with unique pharmacologic properties that make it a potential candidate for pain management. However, the efficacy and safety of haloperidol for pain management remain controversial. This narrative review provides a summary of the current literature on the use of haloperidol for pain management, including its pharmacology, clinical effectiveness, adverse effects, and dosing regimens. We performed a comprehensive search of the literature for this review. The most robust clinical data from the past decade suggest that haloperidol has good efficacy in the treatment of pain related to gastroparesis and migraines and has shown promise for opioid use reduction in patients with chronic pain or receiving palliative care. The overall side effect profile is excellent, with zero reported events of QT-related cardiac arrest and minimal reports of sedation and transient extrapyramidal effects such as akathisia. Dosing regimens used were heterogeneous, with most ranging from 1 to 5 mg per dose via intravenous, intramuscular, or oral route. Studies with designs that isolated the effects of haloperidol from combinations of other drugs were extremely limited. Further high-quality prospective studies are needed to determine the ideal role of haloperidol in the routine clinical management of painful conditions. Full article
(This article belongs to the Special Issue Recent Advances in Psychiatric Medications)
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