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Pharmaceuticals
Special Issues
Affective Disorders Psychopharmacology
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Affective Disorders Psychopharmacology

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 985

Special Issue Editor

Dr. Danilo Arnone

E-Mail Website
Guest Editor
1. Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada
2. Mental Health Department, The Ottawa Hospital, Ottawa, ON, Canada
3. King’s College London, Institute of Psychiatry, Psychology and Neuroscience, Psychological Medicine, Centre for Affective Disorders, London, UK
Interests: affective disorders; psychopharmacology, neuroimaging

Special Issue Information

Dear Colleagues,

Affective disorders are complex and heterogeneous conditions with multiple aetiologies. Although current pharmacological treatments, largely discovered serendipitously, are effective, there is a pressing need to expand on current pharmacological strategies with interventions that target brain pathways based on more specific aetiological mechanisms.

This Special Issue, ‘Affective Disorders Psychopharmacology’, welcomes articles addressing current pharmacological approaches to treating affective disorders, and research work that explores limitations of existing strategies and/or offer perspectives related to novel pharmacological treatments.

The issue also welcomes articles reporting new strategies for detecting responsiveness to treatments and refractoriness in relation to the use of pharmacology in affective disorders by utilising a range of technologies including those that explore brain structure and function, putative peripheral markers of affective disorders, and genetic makeup/variation across the spectrum of affective disorders. We also encourage the submission of articles that compare pharmacological strategies with alternative treatment methods, particularly in relation to important topics such as treatment response, aetiological mechanisms, patients’ preferences, etc.

Dr. Danilo Arnone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psychopharmacology
  • affective disorders
  • mood disorders
  • major depressive disorders
  • bipolar affective disorders

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

16 pages, 1982 KiB  
Article
Insights into the Incidence, Course, and Management of Lithium-Induced Hypothyroidism in Real-World Psychiatric Practice in Italy
by Simone Pardossi, Mario Pinzi, Matteo Cattolico, Maria Beatrice Rescalli, Lorenzo Nicchi, Benedetta Tuci, Elisa Mariantoni and Alessandro Cuomo
Pharmaceuticals 2024, 17(11), 1425; https://doi.org/10.3390/ph17111425 - 24 Oct 2024
Viewed by 613
Abstract
Background: Lithium is a cornerstone in the treatment of bipolar disorder (BD). However, lithium use requires careful monitoring of thyroid function due to associated dysfunctions. The aim of our real-world study is to retrospectively evaluate the impact of lithium on thyroid function [...] Read more.
Background: Lithium is a cornerstone in the treatment of bipolar disorder (BD). However, lithium use requires careful monitoring of thyroid function due to associated dysfunctions. The aim of our real-world study is to retrospectively evaluate the impact of lithium on thyroid function and how these thyroid alterations can be measured and managed. Methods: A retrospective observational study was performed on 150 patients with BD who started lithium treatment at the University Hospital of Siena. Thyroid function was assessed at baseline and after the introduction of lithium by measuring TSH, T3, and T4 levels at baseline and after 3, 6, 9, and 12 months, during which changes in psychiatric symptoms were also evaluated using specific psychometric scales. Results: Significant increases in TSH levels were observed at 3 and 6 months, while T3 and T4 levels decreased significantly at 3 months. Transient thyroid dysfunction occurred in 36.7% of patients, but normalized without the discontinuation of lithium or need for thyroid replacement therapy in most cases; however, replacement therapy was initiated in 8.7% of patients. There were no significant differences in treatment response between patients with and without thyroid abnormalities, as the abnormalities were transient or resolved. Conclusions: In our sample, lithium induced some cases of hypothyroidism, which, being transient or corrected with replacement therapy, did not interfere with symptomatic improvement. These findings underscore the necessity for continuous thyroid function monitoring during lithium therapy. Clinicians should be prepared to initiate thyroid replacement therapy, when necessary, as timely management can prevent the interruption of lithium treatment and ensure ongoing symptomatic improvement in BD patients. Future studies could include larger and more diverse populations to validate these findings further, extending the follow-up period beyond 12 months to better observe long-term thyroid function trends and management outcomes. Full article
(This article belongs to the Special Issue Affective Disorders Psychopharmacology)
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