Application of 3D Printing Technologies for Drug Delivery

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 606

Special Issue Editor


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Guest Editor
Department of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: 3D printing; cannabinoids; wound healing; polymer science; material science
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Special Issue Information

Dear Colleagues,

The advent of 3D printing technology has ushered in a new era of medical innovations, with far-reaching implications for the pharmaceutical industry. Indeed, the ability to create customized, patient-specific drug delivery systems is one of the most exciting potential applications of this technology. One of the key advantages of using 3D printing for drug delivery is the ability to create complex, intricate structures that can be tailored to the specific needs of individual patients. This could lead to improved drug efficacy, reduced side effects, and enhanced patient outcomes. For instance, 3D printing technology can be leveraged to fabricate personalized dosage forms that precisely match a patient's unique pharmacological requirements, such as specific drug concentrations, release profiles, and delivery mechanisms. Moreover, 3D printing can facilitate the development of innovative drug delivery strategies, such as the creation of implantable or transdermal devices that can provide controlled, sustained release of medications. Additionally, 3D printing can enable the rapid prototyping and production of drug delivery devices, potentially accelerating the development and commercialization of new pharmaceutical products. This Special Issue is open to both original and review articles focusing on the latest innovations and future pathways in the 3D printing of drug delivery systems.

Dr. Eleftherios G. Andriotis
Guest Editor

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Keywords

  • additive manufacturing
  • 3D printing
  • drug delivery systems
  • personalized dosage forms
  • personalized drug delivery systems

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Published Papers (1 paper)

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13 pages, 6743 KiB  
Systematic Review
Advances in Loading Techniques and Quality by Design for Fused Deposition Modeling in Pharmaceutical Production: A Systematic Review
by Yusra Ahmed, Azza A. K. Mahmoud, Krisztina Ludasi and Tamás Sovány
Pharmaceuticals 2024, 17(11), 1496; https://doi.org/10.3390/ph17111496 - 7 Nov 2024
Viewed by 494
Abstract
Background/Objectives: Three-dimensional printing technology has emerging interest in pharmaceutical manufacturing, offering new opportunities for personalized medicine and customized drug delivery systems. Fused deposition modeling (FDM) is highly regarded in the pharmaceutical industry because of its cost effectiveness, easy operation, and versatility in creating [...] Read more.
Background/Objectives: Three-dimensional printing technology has emerging interest in pharmaceutical manufacturing, offering new opportunities for personalized medicine and customized drug delivery systems. Fused deposition modeling (FDM) is highly regarded in the pharmaceutical industry because of its cost effectiveness, easy operation, and versatility in creating pharmaceutical dosage forms. This review investigates different methods of incorporating active pharmaceutical ingredients (APIs) into filament matrices for use in fused deposition modeling (FDM) 3D printing. Methods: Two electronic databases, the Web of Science and PubMed, were utilized to survey the literature. The selected keywords for this review were as follows: fused filament fabrication OR fused deposition modeling OR FDM OR FFF AND 3D printing AND loading techniques OR impregnation techniques AND solid dosage form. Results: This paper evaluates various loading techniques such as soaking, supercritical impregnation, microwave impregnation, and hot-melt extrusion, focusing on their effectiveness and capacity for drug incorporation. Additionally, this review includes a thorough risk assessment of the extrusion process using Ishikawa and SWOT analyses. Conclusions: Overall, this review provides comprehensive insights into the latest advancements in 3D printing for pharmaceutical applications and identifies key areas for future research and development. Full article
(This article belongs to the Special Issue Application of 3D Printing Technologies for Drug Delivery)
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