P2X Receptors and Their Pharmacology
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 February 2025 | Viewed by 275
Special Issue Editor
2. Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro 21040-360, Brazil
Interests: P2X receptors; synthetic molecules; natural products; phytopharmaceuticals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The P2X family constitutes an important class of receptors within the purinergic system. They are identified as membrane ion channels that are preferentially permeable to Na+ and K+ and with significant amounts of Ca+2 that open within milliseconds after interacting with extracellular adenosine 5'-triphosphate (ATP). The P2X2, P2X4 and especially P2X7 subtypes have exceptional abilities to increase plasma membrane permeability. The therapeutic potential of P2X family receptors has been investigated in a number of pathologies, including neuropathic pain, inflammation, depression, irritable bowel syndrome, interstitial cystitis, dysfunctional urinary bladder and cancer. In this context, studying the functioning of the P2X receptors becomes limited by the lack of selective antagonists with potent in vitro and in vivo activity in animal models and appropriate pharmacokinetic and pharmacodynamic properties in humans, which demonstrate a superior effect to the reference drug in clinical trials.
Thus, several research groups and pharmaceutical industries have invested in discovering new antagonists for P2X receptors, mainly for the P2X7 and P2X3 receptor. Additionally, several patents, case studies and clinical trials that focus on P2X receptors have increased in recent years, mainly focusing on the P2X7 receptor.
The proposed topics cover the action of new and already known antagonists in different study models, repositioned drugs, and ongoing studies of P2X receptor activity modulators. Authors are invited to submit original articles on basic research, clinical research, reviews, case studies, and other studies in this field.
Prof. Dr. Robson Xavier Faria
Guest Editor
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Keywords
- compounds
- substances
- synthetic
- natural product
- inhibitor
- purinergic receptor
- ATP
- antagonista
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