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Pharmaceuticals
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Using In Vitro and Ex Vivo Models to Evaluate Strategies...
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Using In Vitro and Ex Vivo Models to Evaluate Strategies for Drug Delivery Improvement

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 543

Special Issue Editors

Dr. Dewald Steyn

E-Mail Website
Guest Editor
Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, North-West, South Africa
Interests: drug delivery; drug absorption enhancement; in vitro pharmacokinetics; herb-drug interactions; nose-to-brain delivery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sias Hamman

E-Mail Website
Guest Editor
Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, North-West, South Africa
Interests: drug delivery; drug absorption enhancement; herb–drug interactions; nose-to-brain delivery; ex vivo pharmacokinetic models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This special issue covers topics related to drug delivery improvement that have been evaluated using applicable in vitro and/or ex vivo models.  These models may include epithelial cell lines grown as monolayers on insert membranes and/or excised epithelial tissues mounted in Ussing type diffusion chambers for measurement of drug permeation.  Contributions on models representing any route of drug administration will be accepted including gastrointestinal tract epithelium (oral administration), nasal respiratory and olfactory epithelium (intranasal and intra-respiratory administration), mouth, cheek, and tongue epithelium (buccal and/or sublingual administration) and the skin (transdermal administration) amongst others.  Drug delivery improvements achieved by means of formulation approaches such as carrier systems (e.g., nanoparticulate systems and cyclodextrin inclusion complexes), smart delivery systems (thermosensitive gel systems), drug absorption enhancers (e.g., chitosan, surfactants etc.) or by enhancement of solubility (e.g., amorphous solid dispersions) will be considered for inclusion in the special issue.

Dr. Dewald Steyn
Prof. Dr. Sias Hamman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioenhancers
  • epithelial tissue
  • formulation approaches
  • in vitro models
  • ex vivo models
  • nanoparticulate systems
  • permeation enhancement
  • smart delivery systems
  • solubility enhancement

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Published Papers (1 paper)

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Review

51 pages, 1719 KiB  
Review
Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models
by Johan D. Steyn, Anja Haasbroek-Pheiffer, Wihan Pheiffer, Morné Weyers, Suzanne E. van Niekerk, Josias H. Hamman and Daniélle van Staden
Pharmaceuticals 2025, 18(2), 195; https://doi.org/10.3390/ph18020195 - 31 Jan 2025
Viewed by 228
Abstract
Drugs administered by means of extravascular routes of drug administration must be absorbed into the systemic circulation, which involves the movement of the drug molecules across biological barriers such as epithelial cells that cover mucosal surfaces or the stratum corneum that covers the [...] Read more.
Drugs administered by means of extravascular routes of drug administration must be absorbed into the systemic circulation, which involves the movement of the drug molecules across biological barriers such as epithelial cells that cover mucosal surfaces or the stratum corneum that covers the skin. Some drugs exhibit poor permeation across biological membranes or may experience excessive degradation during first-pass metabolism, which tends to limit their bioavailability. Various strategies have been used to improve drug bioavailability. Absorption enhancement strategies include the co-administration of chemical permeation enhancers, enzymes, and/or efflux transporter inhibitors, chemical changes, and specialized dosage form designs. Models with physiological relevance are needed to evaluate the efficacy of drug absorption enhancement techniques. Various in vitro cell culture models and ex vivo tissue models have been explored to evaluate and quantify the effectiveness of drug permeation enhancement strategies. This review deliberates on the use of in vitro and ex vivo models for the evaluation of drug permeation enhancement strategies for selected extravascular drug administration routes including the nasal, oromucosal, pulmonary, oral, rectal, and transdermal routes of drug administration. Full article
(This article belongs to the Special Issue Using In Vitro and Ex Vivo Models to Evaluate Strategies for Drug Delivery Improvement)
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