Purinergic Signaling: A New Pharmacological Target
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 December 2024 | Viewed by 1862
Special Issue Editor
Special Issue Information
Dear Colleagues,
Proposed in 1972, purinergic signaling is characterized by the relationship between signaling components, receptors, and specific enzymes. The purinergic system is characterized by the action of extracellular nucleotides and nucleosides that are degraded by the action of several ectonucleotidases. ATP is an intracellular energy molecule, but it can be released from various types of cells after damage. Thus, after release, it can activate receptors or be rapidly decomposed by ectonucleotidases. Purinergic signaling receptors are classified into two main groups: P1 nucleoside receptor and P2 purinoceptor. All cells have components of the purinergic system and can release nucleotides in a controlled situation. The mechanisms related to the release of nucleotides have been an intense focus of research activities, and studies have extensively investigated the pharmacology and biochemistry of purinergic signaling. More recently, the focus has been on the therapeutic potential of components of the purinergic system, especially in relation to purinergic receptors. It is now established that changes in purinergic signaling are involved in the therapy of many diseases, in addition to being related to the effects of physical exercise and nutraceutical molecules on the body.
This Special Issue aims to present and discuss the advancement of research and innovative therapies involving the purinergic system and diseases with a high impact on society, such as diabetes, hypertension, atherosclerosis, heart disease, cancer, chronic kidney disease, neurological diseases such as epilepsy, neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis, and the possibility of involving communicable and chronic emerging diseases. We solicit high-quality original research articles as well as review articles focused on the latest research and new findings on the immune system and chronic diseases, as well as the innovative mechanisms related to the development of an inflammatory process in chronic diseases.
Dr. Margarete Dulce Bagatini
Guest Editor
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Keywords
- purinergic receptors
- ectonucleotidases
- nucleotides
- nucleoside
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