pH-Responsive Nanoparticles for Drug Delivery

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 2523

Special Issue Editors


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Guest Editor
Nanovaccine Institute, Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA
Interests: micelle; photo-immunotherapy; liposomes; drug delivery systems
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Guest Editor
Nanovaccine Institute, Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA
Interests: polymer nanoparticles; vascular nanomedicine; nanotoxicology; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine, George Washington University, Washington, DC 20052, USA
Interests: nanoparticles; photothermal therapy; extracellular vesicles; cancer immunotherapies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advancements in nanotechnology have led to intelligent drug delivery systems that can regulate the release of therapeutic cargo in a temporally, spatially, and stimuli-responsive manner. The efficacy of these intelligent nanoparticles can be enhanced by improving their responsiveness to external environmental stimuli, such as pH, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), and may favor targeted drug delivery. Of these various stimuli, the pH gradient has been widely explored as a tool to elicit the site-specific drug release at the organ, tissue, and sub-cellular levels by the tailored nanoparticles. Several research groups are actively investigating novel approaches in the design and engineering of pH-responsive nanoparticles to facilitate drug delivery. Henceforth, these continuous efforts promote the development of pH-responsive nanoparticles as potential nanomedicines for extensive biomedical applications. We welcome manuscripts focusing on pH-responsive nanoparticles that could improve precision therapy.

Dr. Saji Uthaman
Dr. Susheel Kumar Nethi
Dr. Kondareddy Cherukula
Guest Editors

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Published Papers (1 paper)

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Research

14 pages, 3756 KiB  
Article
Formulation and Characterization of Curcumin Niosomes: Antioxidant and Cytotoxicity Studies
by Shazia Akram Ghumman, Amna Ijaz, Sobia Noreen, Afeefa Aslam, Rizwana Kausar, Ali Irfan, Sumera Latif, Gamal A. Shazly, Pervaiz Akhtar Shah, Maria Rana, Asma Aslam, Momina Altaf, Katarzyna Kotwica-Mojzych and Yousef A. Bin Jardan
Pharmaceuticals 2023, 16(10), 1406; https://doi.org/10.3390/ph16101406 - 3 Oct 2023
Cited by 7 | Viewed by 1738
Abstract
Curcumin’s applications in the treatment of conditions including osteoarthritis, dementia, malignancies of the pancreas, and malignancies of the intestines have drawn increasing attention. It has several wonderful qualities, including being an anti-inflammatory agent, an anti-mutagenic agent, and an antioxidant, and has substantially reduced [...] Read more.
Curcumin’s applications in the treatment of conditions including osteoarthritis, dementia, malignancies of the pancreas, and malignancies of the intestines have drawn increasing attention. It has several wonderful qualities, including being an anti-inflammatory agent, an anti-mutagenic agent, and an antioxidant, and has substantially reduced inherent cytotoxicity outcomes. Although curcumin possesses multiple known curative properties, due to its limited bioavailability, it is necessary to develop efficient strategies to overcome these hurdles. To establish an effective administration method, various niosomal formulations were optimized using the Box–Behnken design and assessed in the current investigation. To examine the curcumin niosomes, zeta sizer, zeta potential, entrapment efficiency, SEM, antioxidant potential, cytotoxicity, and release studies were performed. The optimized curcumin niosomes exhibited an average particle size of 169.4 nm, a low PDI of 0.189, and high entrapment efficiency of 85.4%. The release profile showed 79.39% curcumin after 24 h and had significantly higher antioxidant potential as compared with that of free curcumin. The cytotoxicity results of curcumin niosomes presented increased mortality in human ovarian cancer A2780. Full article
(This article belongs to the Special Issue pH-Responsive Nanoparticles for Drug Delivery)
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