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Pharmaceutics
Special Issues
Light and Oxygen for the Cellular Drug Delivery and Tracking
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Light and Oxygen for the Cellular Drug Delivery and Tracking

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 4784

Special Issue Editors

Dr. Dorota Bartusik-Aebisher

E-Mail Website
Guest Editor
Department of Biochemistry and General Chemistry, University of Rzeszów, 35-310 Rzeszów, Poland
Interests: drug delivery; breast cancer treatment; magnetic resonance imaging; magnetic resonance spectroscopy; drug tracking; drug monitoring; molecular imaging
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. David Aebisher

E-Mail Website
Guest Editor
Department of Photomedicine and Physical Chemistry, Medical College, University of Rzeszów, 35-310 Rzeszów, Poland
Interests: photochemistry; photobiology; medical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will be dedicated to Photodynamic therapy (PDT) which uses dyes, light and oxygen to destroy tumors. PDT is an emerging treatment method for cancer and other diseases that uses photo-generated reactive oxygen species (ROS) to damage targeted cancer cells or to inactivate bacteria. For generation of ROS, a PDT treatment method employs photosensitizers (PS) that are excited by external illumination provided by visible light at power levels that do not damage healthy tissue. The primary ROS generated is singlet oxygen (1O2) which reacts with cell molecules ultimately resulting in tissue damage and cell death. The mechanism of singlet oxygen formation in this system is energy transfer from excited PS to ground state oxygen. Other ROS such as superoxide and hydroxyl radical are also generated to a much lesser extent and can be also toxic to cells. This Special Issue of Light and Oxygen for Cellular Drug Delivery and Tracking will cover all aspects of this field and welcomes both original research and comprehensive review papers, case reports to guide a wide readership toward the most recent and ground-breaking research.

Dr. Dorota Bartusik-Aebisher
Dr. David Aebisher
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photodynamic therapy
  • photosynthetizers
  • light
  • oxygen

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Published Papers (1 paper)

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Review

14 pages, 1442 KiB  
Review
Photodynamic Therapy in Orthodontics: A Literature Review
by Marcin Olek, Agnieszka Machorowska-Pieniążek, Wojciech Stós, Janusz Kalukin, Dorota Bartusik-Aebisher, David Aebisher, Grzegorz Cieślar and Aleksandra Kawczyk-Krupka
Pharmaceutics 2021, 13(5), 720; https://doi.org/10.3390/pharmaceutics13050720 - 14 May 2021
Cited by 14 | Viewed by 4010
Abstract
Treatment of malocclusions using fixed orthodontic appliances makes it difficult for patients to perform hygiene procedures. Insufficient removal of bacterial biofilm can cause enamel demineralization, manifesting by visible white spot lesions or periodontal diseases, such as gingivitis periodontitis or gingival hyperplasia. The classic [...] Read more.
Treatment of malocclusions using fixed orthodontic appliances makes it difficult for patients to perform hygiene procedures. Insufficient removal of bacterial biofilm can cause enamel demineralization, manifesting by visible white spot lesions or periodontal diseases, such as gingivitis periodontitis or gingival hyperplasia. The classic methods of preventing the above problems include, in addition to proper hygiene, ultrasonic scaling, periodontal debridement, and oral rinses based on chlorhexidine. New alternative methods of reducing plaque around brackets are being developed. There is a growing interest among researchers in the possibility of using photodynamic therapy in orthodontics. A literature search for articles corresponding to the topic of this review was performed using the PubMed and Scopus databases and the following keywords: ‘photodynamic therapy’, ‘orthodontics’, and ‘photosensitizer(s)’. Based on the literature review, two main directions of research can be distinguished: clinical research on the use of photodynamic therapy in the prevention of white spot lesions and periodontal diseases, and ex vivo research using a modified orthodontic adhesive by adding photosensitizers to them. Methylene blue is the most frequently used photosensitizer in clinical trials. The effectiveness of antimicrobial photodynamic therapy is mainly compared to the ultrasonic scaler as a single therapy or as an adjunct to the ultrasonic scaler. In their conclusions, the researchers most often emphasize the effectiveness of antimicrobial photodynamic therapy in reducing microbial levels in patients treated with fixed appliances and the possibility of using it as an alternative to routine procedures aimed at maintaining a healthy periodontium. The authors suggest further research on the use of photodynamic therapy to prove the validity of this method in orthodontics. It should also not be forgotten that proper hygiene is the basis for maintaining oral cavity health, and its neglect is a contraindication to orthodontic treatment. Full article
(This article belongs to the Special Issue Light and Oxygen for the Cellular Drug Delivery and Tracking)
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