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Pharmaceutics
Special Issues
Drug Delivery Systems for Tissue Engineering
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Drug Delivery Systems for Tissue Engineering

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 8444

Special Issue Editors

Dr. Cédric Chauvierre

E-Mail Website
Guest Editor
Laboratory for Vascular Translational Science INSERM U1148 - Université de Paris, F-75018 Paris, France
Interests: polymers; nano-microparticles; targeted therapy; molecular imaging; cardiovascular diseases
Dr. Teresa Simon-Yarza

E-Mail Website
Guest Editor
Laboratory for Vascular Translational Science INSERM U1148 - Université de Paris, F-75018 Paris, France
Interests: biomaterials; hydrogels; drug delivery; tissue engineering; medicine repair
Dr. Graciela Pavon-Djavid

E-Mail Website
Guest Editor
Laboratory for Vascular Translational Science INSERM U1148, Université Sorbonne Paris Nord, 99 Avenue Jean Baptiste Clément, 93430 Villetaneuse, France
Interests: oxidative stress; nanomaterials; tissue repair; antioxidants; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The great progress made in recent years in the field of tissue engineering highlights the impact that this area will have in the coming decade for the development of relevant tissue models (healthy or diseased), not only for the evaluation of new drugs but also as an alternative to animals to study physiological and pathophysiological process, and from a repair medicine perspective. To achieve these goals, a key aspect is the ability to create innovative biocompatible constructs that act as delivery systems to release molecules involved in biological processes in order to regulate cellular behavior. This undoubtedly requires the joint efforts of scientists from disciplines as diverse as engineers, chemists, biologists, pharmacists, and others.

The aim of this Special Issue is to bring together researchers working on the gap of drug delivery systems for tissue engineering using biomaterials to give readers a comprehensive overview of the latest relevant developments, while highlighting the main difficulties faced nowadays. In this way, the challenges of the near future will be outlined serving as starting point for innovative research strategies.

Dr. Cédric Chauvierre
Dr. Teresa Simon-Yarza
Dr. Graciela Pavon-Djavid
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • microparticles
  • biomaterials
  • scaffolds
  • hydrogels
  • organoids
  • cell therapy
  • repair medicine
  • in vitro 3D models

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Published Papers (2 papers)

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Research

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19 pages, 67230 KiB  
Article
3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton’s Jelly Mesenchymal Stem Cells
by Maria Camilla Ciardulli, Joseph Lovecchio, Pasqualina Scala, Erwin Pavel Lamparelli, Tina Patricia Dale, Valentina Giudice, Emanuele Giordano, Carmine Selleri, Nicholas Robert Forsyth, Nicola Maffulli and Giovanna Della Porta
Pharmaceutics 2021, 13(9), 1448; https://doi.org/10.3390/pharmaceutics13091448 - 10 Sep 2021
Cited by 24 | Viewed by 3672
Abstract
The present work described a bio-functionalized 3D fibrous construct, as an interactive teno-inductive graft model to study tenogenic potential events of human mesenchymal stem cells collected from Wharton’s Jelly (hWJ-MSCs). The 3D-biomimetic and bioresorbable scaffold was functionalized with nanocarriers for the local controlled [...] Read more.
The present work described a bio-functionalized 3D fibrous construct, as an interactive teno-inductive graft model to study tenogenic potential events of human mesenchymal stem cells collected from Wharton’s Jelly (hWJ-MSCs). The 3D-biomimetic and bioresorbable scaffold was functionalized with nanocarriers for the local controlled delivery of a teno-inductive factor, i.e., the human Growth Differentiation factor 5 (hGDF-5). Significant results in terms of gene expression were obtained. Namely, the up-regulation of Scleraxis (350-fold, p ≤ 0.05), type I Collagen (8-fold), Decorin (2.5-fold), and Tenascin-C (1.3-fold) was detected at day 14; on the other hand, when hGDF-5 was supplemented in the external medium only (in absence of nanocarriers), a limited effect on gene expression was evident. Teno-inductive environment also induced pro-inflammatory, (IL-6 (1.6-fold), TNF (45-fold, p ≤ 0.001), and IL-12A (1.4-fold)), and anti-inflammatory (IL-10 (120-fold) and TGF-β1 (1.8-fold)) cytokine expression upregulation at day 14. The presented 3D construct opens perspectives for the study of drug controlled delivery devices to promote teno-regenerative events. Full article
(This article belongs to the Special Issue Drug Delivery Systems for Tissue Engineering)
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Review

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32 pages, 2590 KiB  
Review
Achievements in Mesoporous Bioactive Glasses for Biomedical Applications
by María Vallet-Regí, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone and Sonia Fiorilli
Pharmaceutics 2022, 14(12), 2636; https://doi.org/10.3390/pharmaceutics14122636 - 29 Nov 2022
Cited by 18 | Viewed by 3392
Abstract
Nowadays, mesoporous bioactive glasses (MBGs) are envisaged as promising candidates in the field of bioceramics for bone tissue regeneration. This is ascribed to their singular chemical composition, structural and textural properties and easy-to-functionalize surface, giving rise to accelerated bioactive responses and capacity for [...] Read more.
Nowadays, mesoporous bioactive glasses (MBGs) are envisaged as promising candidates in the field of bioceramics for bone tissue regeneration. This is ascribed to their singular chemical composition, structural and textural properties and easy-to-functionalize surface, giving rise to accelerated bioactive responses and capacity for local drug delivery. Since their discovery at the beginning of the 21st century, pioneering research efforts focused on the design and fabrication of MBGs with optimal compositional, textural and structural properties to elicit superior bioactive behavior. The current trends conceive MBGs as multitherapy systems for the treatment of bone-related pathologies, emphasizing the need of fine-tuning surface functionalization. Herein, we focus on the recent developments in MBGs for biomedical applications. First, the role of MBGs in the design and fabrication of three-dimensional scaffolds that fulfil the highly demanding requirements for bone tissue engineering is outlined. The different approaches for developing multifunctional MBGs are overviewed, including the incorporation of therapeutic ions in the glass composition and the surface functionalization with zwitterionic moieties to prevent bacterial adhesion. The bourgeoning scientific literature on MBGs as local delivery systems of diverse therapeutic cargoes (osteogenic/antiosteoporotic, angiogenic, antibacterial, anti-inflammatory and antitumor agents) is addressed. Finally, the current challenges and future directions for the clinical translation of MBGs are discussed. Full article
(This article belongs to the Special Issue Drug Delivery Systems for Tissue Engineering)
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