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Photonics
Special Issues
Biomedical Optics：Imaging, Sensing and Therapy
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Biomedical Optics：Imaging, Sensing and Therapy

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 945

Special Issue Editors

Dr. Mengyu Jia

E-Mail Website
Guest Editor
College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, China
Interests: intersection of light and radiation with a focus on novel imaging systems; algorithms that maximize functional information obtained from tissue
Dr. Xu Cao

E-Mail Website
Guest Editor
Department of Medical Physic; University of Wisconsin-Madison, Madison, WI, USA
Interests: lucidating the mechanism of FLASH effect; developing dosimetry techniques for FLASH radiation therapy utilizing biomedical optical technologies
Dr. Yihan Wang

E-Mail Website
Guest Editor
Research Center of Molecular and Neuro Imaging of Ministry of Education; School of Life Science and Technology, Xidian University, Xi’an, China
Interests: developing new functional optoacoustic/diffuse optical imaging systems and image reconstruction algorithms for pre-clinical and clinical applications

Special Issue Information

Dear Colleagues,

We are aiming at cutting-edge optical and optical-based hybrid imaging systems and image reconstruction algorithms to exploit the interactions of light with biological tissues in vivo and in vitro. This is a multidisciplinary field combining physics, biology, medicine, and computer science to characterize and analyze the optical properties of biological tissues on subcellular, cellular, and tissue scales and their changes related to metabolism and functional information. The ultimate goal is to advance related disease diagnosis and therapy patterns, benefit potential treatment outcomes, and/or develop an in-depth understanding of the biological processes.

This Special Issue on “Biomedical Optics：Imaging, Sensing and Therapy” will welcome comprehensive research directions, including the following:

  • The development and validation of spectroscopic and/or imaging instrumentation on phantoms and on ex vivo and in vivo tissues;
  • The forward modeling of photon migration in tissues and inverse problem solving;
  • Image reconstruction by using advanced traditional methods or machine learning-based algorithm;
  • The processing of multidimensional data using classification and machine learning methods;
  • The development of multimodal, multispectral, and/or multiscale approaches;
  • The applications of imaging and laser technologies in preclinical and clinical diagnosis and therapy.

Dr. Mengyu Jia
Dr. Xu Cao
Dr. Yihan Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photoacoustic tomography
  • Cherenkov imaging
  • diffuse optical tomography
  • optical coherence tomography
  • functional near-infrared spectroscopy
  • diffuse correlation spectroscopy
  • X-ray computed tomography
  • X-ray excited luminescence imaging
  • fluorescence molecular tomography
  • surface-enhanced Raman spectroscopy
  • high-throughput Raman imaging
  • photodynamic therapy
  • laser therapy
  • optical microscopy

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

11 pages, 1534 KiB  
Communication
SVM-Based Optical Detection of Retinal Ganglion Cell Apoptosis
by Mukhit Kulmaganbetov, Ryan Bevan, Andrew Want, Nantheera Anantrasirichai, Alin Achim, Julie Albon and James Morgan
Photonics 2025, 12(2), 128; https://doi.org/10.3390/photonics12020128 - 31 Jan 2025
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Abstract
Background: Retinal ganglion cell (RGC) loss is crucial in eye diseases like glaucoma. Axon damage and dendritic degeneration precede cell death, detectable within optical coherence tomography (OCT) resolution, indicating their correlation with neuronal degeneration. The purpose of this study is to evaluate [...] Read more.
Background: Retinal ganglion cell (RGC) loss is crucial in eye diseases like glaucoma. Axon damage and dendritic degeneration precede cell death, detectable within optical coherence tomography (OCT) resolution, indicating their correlation with neuronal degeneration. The purpose of this study is to evaluate the optical changes of early retinal degeneration. Methods: The detection of optical changes in the axotomised retinal explants was completed in six C57BL/6J mice. OCT images were acquired up to 120 min from enucleation. A grey-level co-occurrence-based texture analysis was performed on the inner plexiform layer (IPL) to monitor changes in the optical speckles using a principal component analysis (PCA) and a support vector machine (SVM). In parallel tests, retinal transparency was confirmed by a comparison of the modulation transfer functions (MTFs) at 0 and 120 min. Results: Quantitative confirmation by analysis of the MTFs confirmed the non-degradation of optical transparency during the imaging period: MTF (fx) = 0.267 ± 0.02. Textural features in the IPL could discriminate between the optical signals of RGC degeneration. The mean accuracy of the SVM classification was 86.3%; discrimination was not enhanced by the combination of the SVM and PCA (81.9%). Conclusions: Optical changes in the IPL can be detected using OCT following RGC axotomy. High-resolution OCT can provide an index of retinal neuronal integrity and its degeneration. Full article
(This article belongs to the Special Issue Biomedical Optics：Imaging, Sensing and Therapy)
12 pages, 1119 KiB  
Article
Photodynamic Therapy Effects with Curcuma longa L. Active Ingredients in Gel and Blue LED on Acne: A Randomized, Controlled, and Double-Blind Clinical Study
by Jaqueline de Souza Crusca, Luis Henrique Oliveira de Moraes, Thiago Gomes Figueira, Nivaldo Antonio Parizotto and Gerson Jhonatan Rodrigues
Photonics 2025, 12(1), 80; https://doi.org/10.3390/photonics12010080 - 17 Jan 2025
Viewed by 447
Abstract
Photodynamic therapy (PDT) using the photosensitizer curcumin and blue light has a relevant effect on bacteriological decontamination caused by C. acne. The aim is to verify PDT’s effectiveness with curcumin in individuals diagnosed with moderate to severe acne. This study was carried out [...] Read more.
Photodynamic therapy (PDT) using the photosensitizer curcumin and blue light has a relevant effect on bacteriological decontamination caused by C. acne. The aim is to verify PDT’s effectiveness with curcumin in individuals diagnosed with moderate to severe acne. This study was carried out on a total of 35 volunteers of both genders (12–32 years old), with moderate to severe acne vulgaris. The volunteers were randomized into five groups: L (LED), V (Vehicle), C (Curcumin), L + V (LED + Vehicle), and L + C (LED + Curcumin). The curcumin gel and LED with blue wavelength (450 nm ± 10 nm) were used. Qualitative and quantitative evaluations were used to verify the efficacy of the treatment by counting inflamed and non-inflamed lesions. The L + C group until day 30 showed a lower percentage of inflammatory lesions than the Vehicle group for the same period. On day 60, the L + C group showed lower inflammatory lesion values compared to the other groups. Intragroup analysis of hydration in the Vehicle group (V) showed a difference on days 30 and 60 compared to day zero. In an intragroup analysis, the L + C group showed a decrease in the mean scores on day 30, and day 60 compared to day zero, showing an improvement in the psychosocial status of these volunteers. Taken together, our results showed that the combination of blue LED therapy and curcumin proved to be an effective and safe treatment for reducing inflamed acne lesions in individuals with moderate to severe acne, while also enhancing their quality of life from a psychosocial perspective. Full article
(This article belongs to the Special Issue Biomedical Optics：Imaging, Sensing and Therapy)
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