Electrospun Nanofibers: Current Advances and Future Perspective

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 5 January 2025 | Viewed by 9689

Special Issue Editors


E-Mail Website
Guest Editor
Higher Polytechnic School, UAX-Universidad Alfonso X el Sabio, Avda. Universidad, 1, Villanueva de la Cañada, 28691 Madrid, Spain
Interests: polymer composites; mechanical properties; nanomaterials; biomaterials; membranes; fiber; bioactive molecules; active packaging; water decontamination

E-Mail Website
Guest Editor
FEnBeT Research Group, UCAM-Universidad Católica de Murcia, Murcia, Spain
Interests: food science; bioactive molecules; active packaging; water decontamination
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Green and Innovative Technologies for Food, Environment and Bioengineering Research Group (FEnBeT), Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica San Antonio de Murcia, Campus de los Jerónimos 135, Guadalupe, 30107 Murcia, Spain
Interests: food science; bioactive molecules; active packaging; water decontamination

E-Mail Website
Guest Editor
Facultad de Ingeniería Agrícola, Universidad Técnica de Manabí (UTM), Avenida Urbina y Che Guevara, Portoviejo 130105, Ecuador
Interests: polymer composites; biomaterials; membranes; fiber; bioactive molecules; water decontamination

Special Issue Information

Dear Colleagues,

The mechanism by which a viscoelastic fluid can be transformed into fibrous membranes under the influence of an electric field was first observed more than a century ago. Since then, many applications of this transformation have been considered, especially after the first electrospinning experiments were reported in the mid-1990s. To date, this technique has allowed the fabrication of fibrous membranes tailored from organic and inorganic precursors, such as polymers and ceramics. Current applications of the electro-spinning technique cover various industrial sectors, with a special emphasis on the areas of food, the environment and bioengineering.

This technique is highly appealing to contemporary researchers owing to its versatility. Indeed, the final performance of these materials is influenced by three main factors. The first main influence is that of the physicochemical properties of the precursor solution such as viscosity, viscoelasticity, conductivity, surface tension, as well as the dielectric constant of the medium. The second major influence came from the experimental variables, related to the configuration used during the electrospinning process, such as the hydrostatic pressure in the capillary tube, the difference in electrical potential at the tip of the capillary, the type of collector, and the distance between the tip and the manifold. Last but not least, the environmental conditions such as temperature, relative humidity, and air speed also play a crucial role. Moreover, these extrinsic factors modulate the structure of the resulting membrane, producing different orientations or morphologies, ranging from microparticles to fibers or mixed morphologies such as fibers functionalized with microparticles. Likewise, this technique not only makes it possible to control the dimensions or diameters of the microparticles, but also allows for the modulation of the morphology and texture of their surface, with structures ranging from those with smooth fibers to rough, porous and hollow structures. Thus, the microstructure of these compounds will modulate their physico-chemical and biological response.

In this Special Issue, we welcome contributions aiming to address the current advances in and future perspectives of electrospun nanofibers. These advances should be applied to various industrial sectors including, but not limited to, the food, environment and bioengineering sectors. Research, covering the combination of natural/synthetic polymers combined with particles, molecules, biomolecules and nanoparticles, as well as aiming to enhance material functionality, is welcome. 

Dr. Camilo Zamora-Ledezma
Dr. Vicente M. Gómez-López
Dr. Patricia Navarro Martínez
Dr. Ezequiel Zamora-Ledezma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer composites
  • mechanical properties
  • nanomaterials
  • biomaterials
  • membranes
  • fiber
  • bioactive molecules
  • active packaging
  • water decontamination
  • edible films
  • coatings

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 8160 KiB  
Communication
Fabrication and Characterization of Electrospun Cu-Doped TiO2 Nanofibers and Enhancement of Photocatalytic Performance Depending on Cu Content and Electron Beam Irradiation
by So-Hyeon Lee, Kyeong-Han Na, Jae-Yoon Kim, Han-Sol Yoon, HyukSu Han and Won-Youl Choi
Polymers 2024, 16(5), 694; https://doi.org/10.3390/polym16050694 - 4 Mar 2024
Viewed by 1487
Abstract
Titanium dioxide (TiO₂) is a widely studied material with many attractive properties such as its photocatalytic features. However, its commercial use is limited due to issues such as deactivation in the visible spectrum caused by its wide bandgap and the short lifetime of [...] Read more.
Titanium dioxide (TiO₂) is a widely studied material with many attractive properties such as its photocatalytic features. However, its commercial use is limited due to issues such as deactivation in the visible spectrum caused by its wide bandgap and the short lifetime of photo-excited charge carriers. To overcome these challenges, various modifications could be considered. In this study, we investigated copper doping and electron beam treatment. As-spun TiO2 nanofibers were fabricated by electrospinning a TiO2 sol, which obtained viscosity through a polyvinylpyrrolidone (PVP) matrix. Cu-doped TiO2 nanofibers with varying dopant concentrations were synthesized by adding copper salts. Then, the as-spun nanofibers were calcined for crystallization. To evaluate photocatalytic performance, a photodegradation test of methylene blue aqueous solution was performed for 6 h. Methylene blue concentration was measured over time using UV-Vis spectroscopy. The results showed that Cu doping at an appropriate concentration and electron-beam irradiation showed improved photocatalytic efficiency compared to bare TiO2 nanofibers. When the molar ratio of Cu/Ti was 0.05%, photodegradation rate was highest, which was 10.39% higher than that of bare TiO2. As a result of additional electron-beam treatment of this sample, photocatalytic efficiency improved up to 8.93% compared to samples without electron-beam treatment. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
Show Figures

Graphical abstract

29 pages, 6632 KiB  
Article
Electrospun Fibers Loaded with Pirfenidone: An Innovative Approach for Scar Modulation in Complex Wounds
by Erika Maria Tottoli, Laura Benedetti, Federica Riva, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Gabriele Ceccarelli and Rossella Dorati
Polymers 2023, 15(20), 4045; https://doi.org/10.3390/polym15204045 - 10 Oct 2023
Cited by 3 | Viewed by 1678
Abstract
Hypertrophic scars (HTSs) are pathological structures resulting from chronic inflammation during the wound healing process, particularly in complex injuries like burns. The aim of this work is to propose Biofiber PF (biodegradable fiber loaded with Pirfenidone 1.5 w/w), an electrospun [...] Read more.
Hypertrophic scars (HTSs) are pathological structures resulting from chronic inflammation during the wound healing process, particularly in complex injuries like burns. The aim of this work is to propose Biofiber PF (biodegradable fiber loaded with Pirfenidone 1.5 w/w), an electrospun advanced dressing, as a solution for HTSs treatment in complex wounds. Biofiber has a 3-day antifibrotic action to modulate the fibrotic process and enhance physiological healing. Its electrospun structure consists of regular well-interconnected Poly-L-lactide-co-poly-ε-caprolactone (PLA-PCL) fibers (size 2.83 ± 0.46 µm) loaded with Pirfenidone (PF, 1.5% w/w), an antifibrotic agent. The textured matrix promotes the exudate balance through mild hydrophobic wettability behavior (109.3 ± 2.3°), and an appropriate equilibrium between the absorbency % (610.2 ± 171.54%) and the moisture vapor transmission rate (0.027 ± 0.036 g/min). Through its finer mechanical properties, Biofiber PF is conformable to the wound area, promoting movement and tissue oxygenation. These features also enhance the excellent elongation (>500%) and tenacity, both in dry and wet conditions. The ancillary antifibrotic action of PF on hypertrophic scar fibroblast (HSF) for 3 days downregulates the cell proliferation over time and modulates the gene expression of transforming growth factor β1 (TGF-β1) and α-smooth muscle actin (α-SMA) at 48–72 h. After 6 days of treatment, a decrement of α-SMA protein levels was detected, proving the potential of biofiber as a valid therapeutic treatment for HTSs in an established wound healing process. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
Show Figures

Graphical abstract

16 pages, 2576 KiB  
Article
Design and Fabrication of Electrospun PLA-Based Silica-Modified Composite Nanofibers with Antibacterial Properties for Perspective Wound Treatment
by Kateryna Filatova, Eva Domincova Bergerova, Natalia Kazantseva, Milan Masar, Pavol Suly, Tomas Sopik, Jaroslav Cisar, Silvie Durpekova and Vladimir Sedlarik
Polymers 2023, 15(17), 3500; https://doi.org/10.3390/polym15173500 - 22 Aug 2023
Cited by 2 | Viewed by 1309
Abstract
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties [...] Read more.
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties (scanning electron microscopy, Brunauer–Emmett–Teller analysis, thermogravimetric analysis, water contact angle). High-Performance Liquid Chromatography was used to determine the AMI content in the liquid fractions obtained from the release study. The results show that nanofibers of fumed silica exhibited an aggregated, highly porous structure, whereas nanofibers of mesoporous silica had a spherical morphology. Both silica nanoparticles had a significant effect on the hydrophilic properties of PLA nanofiber surfaces. The liquid fractions were investigated to gauge the encapsulation efficiency (EE) and loading efficiency (LE) of AMI, demonstrating 66% EE and 52% LE for nanofibers of fumed silica compared to nanofibers of mesoporous silica nanoparticles (52% EE and 12.7% LE). The antibacterial activity of the AMI-loaded nanofibers was determined by the Kirby–Bauer Method. These results demonstrated that the PLA-based silica nanofibers effectively enhanced the antibacterial properties against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
Show Figures

Figure 1

25 pages, 4553 KiB  
Article
Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications
by Camilo Zamora-Ledezma, Ana Belén Hernández, Ivan López-González, Jeevithan Elango, Janèle Paindépice, Frank Alexis, Manuela González-Sánchez, Víctor Morales-Flórez, Duncan John Mowbray and Luis Meseguer-Olmo
Polymers 2023, 15(12), 2705; https://doi.org/10.3390/polym15122705 - 16 Jun 2023
Cited by 1 | Viewed by 1931
Abstract
Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications because they [...] Read more.
Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications because they can mimic the native skin microenvironment; however, many open questions such as the interaction mechanism between the skin and the wound dressing material remain unclear. Recently, several biomolecules were intended for use in combination with poly(vinyl alcohol) (PVA) fiber mats to improve their biological response; nevertheless, retinol, an important biomolecule, has not been combined yet with PVA to produce tailored and biofunctional fiber mats. Based on the abovementioned concept, the present work reported the fabrication of retinol-loaded PVA electrospun fiber mats (RPFM) with a variable content of retinol (0 ≤ Ret ≤ 25 wt.%), and their physical–chemical and biological characterization. SEM results showed that fiber mats exhibited diameters distribution ranging from 150 to 225 nm and their mechanical properties were affected with the increasing of retinol concentrations. In addition, fiber mats were able to release up to 87% of the retinol depending on both the time and the initial content of retinol. The cell culture results using primary mesenchymal stem cell cultures proved the biocompatibility of RPFM as confirmed by their effects on cytotoxicity (low level) and proliferation (high rate) in a dose-dependent manner. Moreover, the wound healing assay suggested that the optimal RPFM with retinol content of 6.25 wt.% (RPFM-1) enhanced the cell migratory activity without altering its morphology. Accordingly, it is demonstrated that the fabricated RPFM with retinol content below the threshold 0 ≤ Ret ≤ 6.25 wt.% would be an appropriate system for skin regenerative application. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
Show Figures

Figure 1

Review

Jump to: Research

40 pages, 14083 KiB  
Review
Wound Dressing with Electrospun Core-Shell Nanofibers: From Material Selection to Synthesis
by Nariman Rajabifar, Amir Rostami, Shahnoosh Afshar, Pezhman Mosallanezhad, Payam Zarrintaj, Mohsen Shahrousvand and Hossein Nazockdast
Polymers 2024, 16(17), 2526; https://doi.org/10.3390/polym16172526 - 5 Sep 2024
Cited by 1 | Viewed by 2285
Abstract
Skin, the largest organ of the human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, the repair of skin lesions is a complex and time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment [...] Read more.
Skin, the largest organ of the human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, the repair of skin lesions is a complex and time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment involves the application of a dressing to protect the wound, mitigate the risk of infection, and decrease the likelihood of secondary injuries. Pursuing solutions for accelerating wound healing has resulted in groundbreaking advancements in materials science, from hydrogels and hydrocolloids to foams and micro-/nanofibers. Noting the convenience and flexibility in design, nanofibers merit a high surface-area-to-volume ratio, controlled release of therapeutics, mimicking of the extracellular matrix, and excellent mechanical properties. Core-shell nanofibers bring even further prospects to the realm of wound dressings upon separate compartments with independent functionality, adapted release profiles of bioactive agents, and better moisture management. In this review, we highlight core-shell nanofibers for wound dressing applications featuring a survey on common materials and synthesis methods. Our discussion embodies the wound healing process, optimal wound dressing characteristics, the current organic and inorganic material repertoire for multifunctional core-shell nanofibers, and common techniques to fabricate proper coaxial structures. We also provide an overview of antibacterial nanomaterials with an emphasis on their crystalline structures, properties, and functions. We conclude with an outlook for the potential offered by core-shell nanofibers toward a more advanced design for effective wound healing. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
Show Figures

Figure 1

Back to TopTop