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Polymers
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Functionalized Biomaterials for Medical Applications
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Functionalized Biomaterials for Medical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 10073

Special Issue Editor

Dr. Sandrine Gerber‐Lemaire

E-Mail Website
Guest Editor
Group for Functionalized Biomaterials, Ecole Polytechnique Fédérale de Lausanne, ISIC, CH-1015 Lausanne, Switzerland
Interests: organic synthesis; surface functionalization; polymeric biomaterials; theranosctic nanoparticles; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural and synthetic polymeric biomaterials have emerged as versatile and revolutionary systems in many biomedical applications, including tissue engineering, drug delivery, cell transplantation, biosensors, as well as cell and organoid culture. The composition of synthetic polymers can easily be varied to control their biological interactions by means of specific block assemblies and post-polymerization addition of bioactive chemical cues. Similarly, specific functionalization pathways have been reported for the modification of natural biopolymers to achieve complex materials able to trigger desired bioprocesses in vivo while preventing adverse host responses. The very high flexibility of polymer fabrication and modification allow for many parameters to be efficiently controlled in vivo, such as mechanical properties, degradability, and response to internal or external stimuli.

The sophistication of polymer engineering methods has been accompanied by the development of accurate characterization methods allowing a precise description of polymeric assemblies and a valuable prediction of their interaction with living materials.

In this Special Issue, we welcome research papers and reviews focusing on polymer biomaterials presenting multifunctional surface compositions with particular emphasis on cell transplantation devices and tissue repair composites. The aim is to present recent studies on design, fabrication, and evaluation of functionalized polymeric assemblies able to generate controlled and specific interactions with the host environment.   

Dr. Sandrine Gerber‐Lemaire
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Functionalized polymeric materials
  • Hybrid biomaterials
  • Surface modification
  • Polymer engineering
  • Tissue engineering
  • Cell transplantation
  • Characterization of complex polymeric assemblies
  • Host-material interactions

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Published Papers (2 papers)

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Research

22 pages, 8955 KiB  
Article
Fabrication and Characterization of Chitosan—Tamarind Seed Polysaccharide Composite Film for Transdermal Delivery of Protein/Peptide
by Rishabha Malviya, Anchal Tyagi, Shivkanya Fuloria, Vetriselvan Subramaniyan, Kathiresan Sathasivam, Sonali Sundram, Sundram Karupiah, Srikumar Chakravarthi, Dhanalekshmi Unnikrishnan Meenakshi, Nandan Gupta, Mahendran Sekar, Kalvatala Sudhakar and Neeraj Kumar Fuloria
Polymers 2021, 13(9), 1531; https://doi.org/10.3390/polym13091531 - 10 May 2021
Cited by 12 | Viewed by 3821
Abstract
Transdermal drug delivery is used to deliver a drug by eliminating the first-pass metabolism, which increases the bioavailability of the drug. The present study aims to formulate the chitosan—tamarind seed polysaccharide composite films and evaluate for the delivery of protein/peptide molecules. Nine formulations [...] Read more.
Transdermal drug delivery is used to deliver a drug by eliminating the first-pass metabolism, which increases the bioavailability of the drug. The present study aims to formulate the chitosan—tamarind seed polysaccharide composite films and evaluate for the delivery of protein/peptide molecules. Nine formulations were prepared and evaluated by using different parameters, such as physical appearance, folding endurance, thickness of film, surface pH, weight variation, drug content, surface morphology, percentage moisture intake and uptake, drug release kinetics, and drug permeability. The film weight variance was observed between 0.34 ± 0.002 to 0.47 ± 0.003 g. The drug level of the prepared films was found to be between 96 ± 1.21 and 98 ± 1.33μg. Their intake of moisture ranged between 2.83 ± 0.002 and 3.76 ± 0.001 (%). The moisture absorption of the films ranged from 5.33 ± 0.22 to 10.02 ± 0.61 (%). SEM images revealed a smooth film surface, while minor cracks were found in the film after permeation tests. During the first 4 days, drug release was between 13.75 ± 1.64% and 22.54 ± 1.34% and from day 5 to day 6, it was between 72.67 ± 2.13% and 78.33 ± 3.13%. Drug permeation during the first 4 days was 15.78 ± 1.23 %. Drug permeation (%) during the first 4 days was between 15.78 ± 1.23 and 22.49 ± 1.29 and from day 5 to day 6, it was between 71.49 ± 3.21 and 77.93 ± 3.20. Full article
(This article belongs to the Special Issue Functionalized Biomaterials for Medical Applications)
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15 pages, 6706 KiB  
Article
Morphological and Mechanical Properties of Electrospun Polycaprolactone Scaffolds: Effect of Applied Voltage
by L.A. Can-Herrera, A.I. Oliva, M.A.A. Dzul-Cervantes, O.F. Pacheco-Salazar and J.M. Cervantes-Uc
Polymers 2021, 13(4), 662; https://doi.org/10.3390/polym13040662 - 23 Feb 2021
Cited by 71 | Viewed by 5483
Abstract
The aim of this work is to investigate the effect of the applied voltage on the morphological and mechanical properties of electrospun polycaprolactone (PCL) scaffolds for potential use in tissue engineering. The morphology of the scaffolds was characterized by scanning electron microscopy (SEM), [...] Read more.
The aim of this work is to investigate the effect of the applied voltage on the morphological and mechanical properties of electrospun polycaprolactone (PCL) scaffolds for potential use in tissue engineering. The morphology of the scaffolds was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and the BET techniques for measuring the surface area and pore volume. Stress-strain curves from tensile tests were obtained for estimating the mechanical properties. Additional studies for detecting changes in the chemical structure of the electrospun PCL scaffolds by Fourier transform infrared were performed, while contact angle and X-ray diffraction analysis were realized for determining the wettability and crystallinity, respectively. The SEM, AFM and BET results demonstrate that the electrospun PCL fibers exhibit morphological changes with the applied voltage. By increasing the applied voltage (10 to 25 kV) a significate influence was observed on the fiber diameter, surface roughness, and pore volume. In addition, tensile strength, elongation, and elastic modulus increase with the applied voltage, the crystalline structure of the fibers remains constant, and the surface area and wetting of the scaffolds diminish. The morphological and mechanical properties show a clear correlation with the applied voltage and can be of great relevance for tissue engineering. Full article
(This article belongs to the Special Issue Functionalized Biomaterials for Medical Applications)
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