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Polymers
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Advances in Synthesis and Application of Biomedical Polymer Materials
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Advances in Synthesis and Application of Biomedical Polymer Materials

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 11923

Special Issue Editors

Dr. Weikang Hu

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Hubei University, Wuhan 430062, China
Interests: Biomaterials, Biomedical Polymers, Tissue engineering, 3D printing, Regenerative medicine, Wound healing materials
Special Issues, Collections and Topics in MDPI journals
Dr. Qinghua Xu

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Hubei University, Wuhan 430062, China
Interests: biodegradable polymer; hydrogel; nanoparticle; tissue engineering; drug delivery; biomedical application

Special Issue Information

Dear Colleagues,

Biomedical polymers are naturally derived polymers and synthetic polymers, which play a vital role in tissue engineering and regenerative medicine. Those polymers can be manufactured in medical devices or applied in drug delivery systems. Up to now, biomedical polymers have been extensively developed for preclinical and clinical studies, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In recent years, due to their unique physiological activities and capabilities, bioactive polymers have garnered a lot of attention from researchers recently. Thus, biomedical polymers have a wide space for exploration in biomedical applications.

We are pleased to invite you to a very valuable contribution. This Special Issue aims to have a collection of at least 10 articles on the topic of Advances in the Synthesis and Application of Biomedical Polymer Materials in the open-access journal Polymers (ISSN 2073-4360).

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: biomedical polymers in precision medicine, tissue engineering, regenerative medicine, and clinical translation.

We are looking forward to receiving your contributions.

Kind regards,
Dr. Weikang Hu
Dr. Qinghua Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical polymer
  • drug delivery
  • bioactive polymers
  • tissue engineering
  • regenerative medicine

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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32 pages, 12263 KiB  
Article
Evaluation of Polymeric Micro/Nanofibrous Hybrid Scaffolds Prepared via Centrifugal Nozzleless Spinning for Tissue Engineering Applications
by Miloš Beran, Jana Musílková, Antonín Sedlář, Petr Slepička, Martin Veselý, Zdeňka Kolská, Ondřej Vltavský, Martin Molitor and Lucie Bačáková
Polymers 2025, 17(3), 386; https://doi.org/10.3390/polym17030386 - 31 Jan 2025
Viewed by 250
Abstract
We compared the applicability of 3D fibrous scaffolds, produced by our patented centrifugal spinning technology, in soft tissue engineering. The scaffolds were prepared from four different biocompatible and biodegradable thermoplastics, namely, polylactide (PLA), polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), and poly(1,4-butylene succinate) (PBS) and their [...] Read more.
We compared the applicability of 3D fibrous scaffolds, produced by our patented centrifugal spinning technology, in soft tissue engineering. The scaffolds were prepared from four different biocompatible and biodegradable thermoplastics, namely, polylactide (PLA), polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), and poly(1,4-butylene succinate) (PBS) and their blends. The combined results of SEM and BET analyses revealed an internal hierarchically organized porosity of the polymeric micro/nanofibers. Both nanoporosity and capillary effect are crucial for the water retention capacity of scaffolds designed for tissue engineering. The increased surface area provided by nanoporosity enhances water retention, while the capillary effect facilitates the movement of water and nutrients within the scaffolds. When the scaffolds were seeded with adipose-derived stem cells (ASCs), the ingrowth of these cells was the deepest in the PLA/PCL 13.5/4 (w/w) composite scaffolds. This result is consistent with the relatively large pore size in the fibrous networks, the high internal porosity, and the large specific surface area found in these scaffolds, which may therefore be best suited as a component of adipose tissue substitutes that could reduce postoperative tissue atrophy. Adipose tissue constructs produced in this way could be used in the future instead of conventional fat grafts, for example, in breast reconstruction following cancer ablation. Full article
(This article belongs to the Special Issue Advances in Synthesis and Application of Biomedical Polymer Materials)
18 pages, 4864 KiB  
Article
Highly Efficient Hemostatic Cross-Linked Polyacrylate Polymer Dressings for Immediate Hemostasis
by Tong Ye, Zhiyuan Yang, Ruolin Hao, Jinnan Guo, Guifang Dou, Zhiyun Meng, Shuchen Liu, Ruolan Gu, Zhuona Wu, Yunbo Sun, Peng Han, Yiguang Jin and Hui Gan
Polymers 2024, 16(6), 863; https://doi.org/10.3390/polym16060863 - 21 Mar 2024
Cited by 2 | Viewed by 1535
Abstract
A traumatic hemorrhage is fatal due to the great loss of blood in a short period of time; however, there are a few biomaterials that can stop the bleeding quickly due to the limited water absorption speed. Here, a highly absorbent polymer (HPA), [...] Read more.
A traumatic hemorrhage is fatal due to the great loss of blood in a short period of time; however, there are a few biomaterials that can stop the bleeding quickly due to the limited water absorption speed. Here, a highly absorbent polymer (HPA), polyacrylate, was prepared as it has the best structure–effectiveness relationship. Within a very short period of time (2 min), HPA continually absorbed water until it swelled up to its 600 times its weight; more importantly, the porous structure comprised the swollen dressing. This instantaneous swelling immediately led to rapid hemostasis in irregular wounds. We optimized the HPA preparation process to obtain a rapidly water-absorbent polymer (i.e., HPA-5). HPA-5 showed favorable adhesion and biocompatibility in vitro. A rat femoral arteriovenous complete shear model and a tail arteriovenous injury model were established. HPA exhibited excellent hemostatic capability with little blood loss and short hemostatic time compared with CeloxTM in both of the models. The hemostatic mechanisms of HPA consist of fast clotting by aggregating blood cells, activating platelets, and accelerating the coagulation pathway via water absorption and electrostatic interaction. HPA is a promising highly water-absorbent hemostatic dressing for rapid and extensive blood clotting after vessel injury. Full article
(This article belongs to the Special Issue Advances in Synthesis and Application of Biomedical Polymer Materials)
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21 pages, 4368 KiB  
Article
Upscaling of Electrospinning Technology and the Application of Functionalized PVDF-HFP@TiO2 Electrospun Nanofibers for the Rapid Photocatalytic Deactivation of Bacteria on Advanced Face Masks
by Adriano Cimini, Alessia Borgioni, Elena Passarini, Chiara Mancini, Anacleto Proietti, Luca Buccini, Eleonora Stornelli, Emily Schifano, Simone Dinarelli, Francesco Mura, Claudia Sergi, Irene Bavasso, Barbara Cortese, Daniele Passeri, Enrico Imperi, Teresa Rinaldi, Alfredo Picano and Marco Rossi
Polymers 2023, 15(23), 4586; https://doi.org/10.3390/polym15234586 - 30 Nov 2023
Cited by 5 | Viewed by 2676
Abstract
In recent years, Electrospinning (ES) has been revealed to be a straightforward and innovative approach to manufacture functionalized nanofiber-based membranes with high filtering performance against fine Particulate Matter (PM) and proper bioactive properties. These qualities are useful for tackling current issues from bacterial [...] Read more.
In recent years, Electrospinning (ES) has been revealed to be a straightforward and innovative approach to manufacture functionalized nanofiber-based membranes with high filtering performance against fine Particulate Matter (PM) and proper bioactive properties. These qualities are useful for tackling current issues from bacterial contamination on Personal Protective Equipment (PPE) surfaces to the reusability of both disposable single-use face masks and respirator filters. Despite the fact that the conventional ES process can be upscaled to promote a high-rate nanofiber production, the number of research works on the design of hybrid materials embedded in electrospun membranes for face mask application is still low and has mainly been carried out at the laboratory scale. In this work, a multi-needle ES was employed in a continuous processing for the manufacturing of both pristine Poly (Vinylidene Fluoride-co-Hexafluoropropylene) (PVDF-HFP) nanofibers and functionalized membrane ones embedded with TiO2 Nanoparticles (NPs) (PVDF-HFP@TiO2). The nanofibers were collected on Polyethylene Terephthalate (PET) nonwoven spunbond fabric and characterized by using Scanning Electron Microscopy and Energy Dispersive X-ray (SEM-EDX), Raman spectroscopy, and Atomic Force Microscopy (AFM) analysis. The photocatalytic study performed on the electrospun membranes proved that the PVDF-HFP@TiO2 nanofibers provide a significant antibacterial activity for both Staphylococcus aureus (~94%) and Pseudomonas aeruginosa (~85%), after only 5 min of exposure to a UV-A light source. In addition, the PVDF-HFP@TiO2 nanofibers exhibit high filtration efficiency against submicron particles (~99%) and a low pressure drop (~3 mbar), in accordance with the standard required for Filtering Face Piece masks (FFPs). Therefore, these results aim to provide a real perspective on producing electrospun polymer-based nanotextiles with self-sterilizing properties for the implementation of advanced face masks on a large scale. Full article
(This article belongs to the Special Issue Advances in Synthesis and Application of Biomedical Polymer Materials)
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Review

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20 pages, 56755 KiB  
Review
Chitosan-Based Self-Healing Hydrogel: From Fabrication to Biomedical Application
by Siyu Pan, Chongyu Zhu, Yuwei Wu and Lei Tao
Polymers 2023, 15(18), 3768; https://doi.org/10.3390/polym15183768 - 14 Sep 2023
Cited by 15 | Viewed by 3231
Abstract
Biocompatible self-healing hydrogels are new-generation smart soft materials that hold great promise in biomedical fields. Chitosan-based self-healing hydrogels, mainly prepared via dynamic imine bonds, have attracted broad attention due to their mild preparation conditions, excellent biocompatibility, and self-recovery ability under a physiological environment. [...] Read more.
Biocompatible self-healing hydrogels are new-generation smart soft materials that hold great promise in biomedical fields. Chitosan-based self-healing hydrogels, mainly prepared via dynamic imine bonds, have attracted broad attention due to their mild preparation conditions, excellent biocompatibility, and self-recovery ability under a physiological environment. In this review, we present a comprehensive overview of the design and fabrication of chitosan-based self-healing hydrogels, and summarize their biomedical applications in tissue regeneration, customized drug delivery, smart biosensors, and three/four dimensional (3D/4D) printing. Finally, we will discuss the challenges and future perspectives for the development of chitosan-based self-healing hydrogels in the biomedical field. Full article
(This article belongs to the Special Issue Advances in Synthesis and Application of Biomedical Polymer Materials)
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27 pages, 3246 KiB  
Review
How to Develop Drug Delivery System Based on Carbohydrate Nanoparticles Targeted to Brain Tumors
by Vladimir E. Silant’ev, Mikhail E. Shmelev, Andrei S. Belousov, Aleksandra A. Patlay, Roman A. Shatilov, Vladislav M. Farniev and Vadim V. Kumeiko
Polymers 2023, 15(11), 2516; https://doi.org/10.3390/polym15112516 - 30 May 2023
Cited by 15 | Viewed by 2967
Abstract
Brain tumors are the most difficult to treat, not only because of the variety of their forms and the small number of effective chemotherapeutic agents capable of suppressing tumor cells, but also limited by poor drug transport across the blood-brain barrier (BBB). Nanoparticles [...] Read more.
Brain tumors are the most difficult to treat, not only because of the variety of their forms and the small number of effective chemotherapeutic agents capable of suppressing tumor cells, but also limited by poor drug transport across the blood-brain barrier (BBB). Nanoparticles are promising drug delivery solutions promoted by the expansion of nanotechnology, emerging in the creation and practical use of materials in the range from 1 to 500 nm. Carbohydrate-based nanoparticles is a unique platform for active molecular transport and targeted drug delivery, providing biocompatibility, biodegradability, and a reduction in toxic side effects. However, the design and fabrication of biopolymer colloidal nanomaterials have been and remain highly challenging to date. Our review is devoted to the description of carbohydrate nanoparticle synthesis and modification, with a brief overview of the biological and promising clinical outcomes. We also expect this manuscript to highlight the great potential of carbohydrate nanocarriers for drug delivery and targeted treatment of gliomas of various grades and glioblastomas, as the most aggressive of brain tumors. Full article
(This article belongs to the Special Issue Advances in Synthesis and Application of Biomedical Polymer Materials)
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