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Polymers
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Polymer Materials in Cell Therapy
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Polymer Materials in Cell Therapy

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 11275

Special Issue Editors

Dr. June-Seok Heo

E-Mail Website
Guest Editor
Cell Therapy Center, Severance Hospital, Seoul 03722, Korea
Interests: cell-based diagnostics; cell therapy; regenerative medicine; stem cell biology; tissue engineering
Dr. Faisal Raza

E-Mail Website
Guest Editor
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
Interests: biomimetic nanomedicine; polymeric nanoparticle; drug delivery; cancer; tumor microenvironment; biomaterials; cancer nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of polymer materials has been a key technology for cell therapy and regenerative medicine. In addition, the application of the polymer materials enables one to tune cell attachment, cell proliferation, cell detachment and differentiation, etc. The opportunity to use polymer materials to influence cell activity is based on the adhesion and selective spatial arrangement of diverse cell types on a specific polymer material with preferential chemical composition, surface charge, wettability, and morphology. The latest studies have reported the application of polymer materials to control cell properties for efficient cell therapy. Understanding the roles and mechanism of function of various polymer materials, alone or in combination, in cell therapy is crucial for further advances in tissue engineering. Additionally, a multidisciplinary approach with the integration of different scientific fields is necessary to enable a more comprehensive understanding of the mechanisms of cell therapy, as well as the development of more robust techniques for regenerative medicine. In this Special Issue, we will gather articles that explore the use of biocompatible polymer materials on cell therapy. Original articles reporting studies as well as review articles on the current state-of-the-art are welcome.

Dr. June-Seok Heo
Dr. Faisal Raza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell technology
  • cell therapy
  • polymer
  • regenerative medicine
  • tissue engineering

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Published Papers (3 papers)

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Research

16 pages, 3731 KiB  
Article
Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
by Muhammad Umar Aslam Khan, Saiful Izwan Abd Razaq, Hassan Mehboob, Sarish Rehman, Wafa Shamsan Al-Arjan and Rashid Amin
Polymers 2021, 13(21), 3703; https://doi.org/10.3390/polym13213703 - 27 Oct 2021
Cited by 64 | Viewed by 5389
Abstract
The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various [...] Read more.
The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemocompatible. In vitro, silver sulfadiazine release profile in PBS solution was analyzed via the Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. The drug release kinetics was studied against different mathematical models (zero-order, first-order, Higuchi, Hixson–Crowell, Korsmeyer–Peppas, and Baker–Lonsdale models) and compared their regression coefficient (R2) values. It was observed that drug release follows the Baker–Lonsdale model, as it has the highest value (0.989) of R2. Hence, the obtained results indicated that, due to optimized swelling, wetting, and degradation, the blended composite hydrogel BCH-3 could be an essential wound dressing biomaterial for sustained drug release for skin wound care and treatment. Full article
(This article belongs to the Special Issue Polymer Materials in Cell Therapy)
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14 pages, 3727 KiB  
Article
Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management
by Talib Hussain, Sathishbabu Paranthaman, Syed Mohd Danish Rizvi, Afrasim Moin, Devegowda Vishakante Gowda, Gehad Muhammed Subaiea, Mukhtar Ansari and Abulrahman Sattam Alanazi
Polymers 2021, 13(19), 3210; https://doi.org/10.3390/polym13193210 - 22 Sep 2021
Cited by 16 | Viewed by 2699
Abstract
Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and [...] Read more.
Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and brain distribution study. PAX-RESV-loaded PNPs were prepared by the thin film hydration technique and optimized for different dependent and independent variables by using DoE (Design-Expert) software. The in vitro physiochemical characterization of prepared PAX-RESV-loaded PNPs exhibited appropriate particle size, PDI and % encapsulation efficiency. Cytotoxicity assay revealed that PTX-RESV loaded PNPs had a synergistic antitumor efficacy against C6 glioma cells compared with single and combined pure drugs. Finally, the pharmacokinetic and brain distribution studies in mice demonstrated that the PNPs significantly enhanced the bioavailability of PTX-RESV PNPs than pure PAX and RESV. Thus, the study concluded that PAX-RESV PNPs combination could significantly enhance anti-glioma activity, and this could be developed into a potential glioma treatment strategy. Full article
(This article belongs to the Special Issue Polymer Materials in Cell Therapy)
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13 pages, 2424 KiB  
Article
Bone Marrow Mesenchymal Stromal Cells on Silk Fibroin Scaffolds to Attenuate Polymicrobial Sepsis Induced by Cecal Ligation and Puncture
by Ok-Hyeon Kim, Jun-Hyung Park, Jong-In Son, Ok-Ja Yoon and Hyun-Jung Lee
Polymers 2021, 13(9), 1433; https://doi.org/10.3390/polym13091433 - 29 Apr 2021
Cited by 8 | Viewed by 2129
Abstract
Suitable scaffolds with appropriate mechanical and biological properties can improve mesenchymal stromal cell (MSC) therapy. Because silk fibroins (SFs) are biocompatible materials, they were electrospun and applied as scaffolds for MSC therapy. Consequently, interferon (IFN)-primed human bone marrow MSCs on SF nanofibers were [...] Read more.
Suitable scaffolds with appropriate mechanical and biological properties can improve mesenchymal stromal cell (MSC) therapy. Because silk fibroins (SFs) are biocompatible materials, they were electrospun and applied as scaffolds for MSC therapy. Consequently, interferon (IFN)-primed human bone marrow MSCs on SF nanofibers were administered into a polymicrobial sepsis murine model. The IL-6 level gradually decreased from 40 ng/mL at 6 h after sepsis to 35 ng/mL at 24 h after sepsis. The IL-6 level was significantly low as 5 ng/mL in primed MSCs on SF nanofibers, and 15 ng/mL in primed MSCs on the control surface. In contrast to the acute response, inflammation-related factors, including HO-1 and COX-2 in chronic liver tissue, were effectively inhibited by MSCs on both SF nanofibers and the control surface at the 5-day mark after sepsis. An in vitro study indicated that the anti-inflammatory function of MSCs on SF nanofibers was mediated through enhanced COX-2-PGE2 production, as indomethacin completely abrogated PGE2 production and decreased the survival rate of septic mice. Thus, SF nanofiber scaffolds potentiated the anti-inflammatory and immunomodulatory functions of MSCs, and were beneficial as a culture platform for the cell therapy of inflammatory disorders. Full article
(This article belongs to the Special Issue Polymer Materials in Cell Therapy)
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