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Polymers
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Functional Polymeric Biomaterial
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Functional Polymeric Biomaterial

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 6106

Special Issue Editors

Dr. Mohamed A. Hassan

E-Mail Website1 Website2
Guest Editor
Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria P.O. Box 21934, Egypt
Interests: polymers; wound dressings; antimicrobials; antioxidants; anti-inflammatory; hydrogels; chitosan; hyaluronan; keratinase; lipase; ubiquitin; posttranslational modification; nanoparticles; oxidative stress; mitochondrial dysfunction; oxidative damages
Special Issues, Collections and Topics in MDPI journals
Dr. Tamer M. Tamer

E-Mail Website1 Website2
Guest Editor
Polymer Materials Research Department, Advanced Technologies, and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria P.O. Box 21934, Egypt
Interests: natural polymer; biomedical; pharmaceutical and environmental applications; antimicrobial polymers; polysaccharide; proteins; RO membrane
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Biomaterials are predominantly featured in daily life activities due to their versatility, which facilitates their implementation in a variety of applications. The rapidly expanding necessity to develop innovative biomaterials with extraordinary characteristics that may be adopted in technological breakthroughs is motivating research on advanced functionalized polymeric biomaterials. Furthermore, the functionalization of biomaterials, given their exclusive properties, is decisive in designing new materials to cover unmet requirements. These functionalities are either inherent in the materials or activated by external inputs. Specifically, biopolymers may be functionalized employing specific preparation procedures or incorporating functional groups, fillers, and formulations in different biomaterials. Several established functionalized biopolymers are research hotspots, with countless demonstrated applications in, for example, biomedical applications, wastewater treatment, and electronic and optical polymers. This Special Issue will cover notable recent progress achieved in the research of functional biomaterials, including synthesis, investigation, and potential applications. Both original articles and reviews are accepted for submission.

Dr. Mohamed A. Hassan
Dr. Tamer M. Tamer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable polymers
  • functional biomaterials
  • polymeric biomaterials
  • electronic biopolymers
  • synthetic and natural polymers
  • surface modifications of biopolymers
  • nanocomposites
  • biomedical applications
  • biocompatibility

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Published Papers (2 papers)

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17 pages, 6135 KiB  
Article
Preparation, Characterization, and Bio Evaluation of Fatty N- Hexadecanyl Chitosan Derivatives for Biomedical Applications
by Hanaa Mansour, Samia El-Sigeny, Sarah Shoman, Marwa M. Abu-Serie and Tamer M. Tamer
Polymers 2022, 14(19), 4011; https://doi.org/10.3390/polym14194011 - 25 Sep 2022
Cited by 10 | Viewed by 1516
Abstract
The objective of this study was to improve the antibacterial activities of chitosan via N-alkyl substitution using 1-bromohexadecane. Mono and di substitution (Mono-NHD-Ch and Di-NHD-Ch) were prepared and characterized using FT-IR, HNMR, TGA, DSC, and SEM. Elemental analysis shows an increase in the [...] Read more.
The objective of this study was to improve the antibacterial activities of chitosan via N-alkyl substitution using 1-bromohexadecane. Mono and di substitution (Mono-NHD-Ch and Di-NHD-Ch) were prepared and characterized using FT-IR, HNMR, TGA, DSC, and SEM. Elemental analysis shows an increase in the C/N ratio from 5.45 for chitosan to 8.63 for Mono-NHD-Ch and 10.46 for Di-NHD-Ch. The antibacterial properties were evaluated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus. In the examined microorganisms, the antibacterial properties of the novel alkyl derivatives increased substantially higher than chitosan. The minimum inhibitory concentration (MIC) of Mono-NHD-Ch and Di-NHD-Ch was perceived at 50 μg/mL against tested microorganisms, except for B. cereus. The MTT test was used to determine the cytotoxicity of the produced materials, which proved their safety to fibroblast cells. The findings suggest that the new N-Alkyl chitosan derivatives might be used as antibacterial alternatives to pure chitosan in wound infection treatments. Full article
(This article belongs to the Special Issue Functional Polymeric Biomaterial)
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Review

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24 pages, 4812 KiB  
Review
An Overview of In Vitro Drug Release Methods for Drug-Eluting Stents
by Navideh Abbasnezhad, Nader Zirak, Stéphane Champmartin, Mohammadali Shirinbayan and Farid Bakir
Polymers 2022, 14(13), 2751; https://doi.org/10.3390/polym14132751 - 5 Jul 2022
Cited by 14 | Viewed by 3879
Abstract
The drug release profile of drug-eluting stents (DESs) is affected by a number of factors, including the formulation, design, and physicochemical properties of the utilized material. DES has been around for twenty years and despite its widespread clinical use, and efficacy in lowering [...] Read more.
The drug release profile of drug-eluting stents (DESs) is affected by a number of factors, including the formulation, design, and physicochemical properties of the utilized material. DES has been around for twenty years and despite its widespread clinical use, and efficacy in lowering the rate of target lesion restenosis, it still requires additional development to reduce side effects and provide long-term clinical stability. Unfortunately, for analyzing these implants, there is still no globally accepted in vitro test method. This is owing to the stent’s complexity as well as the dynamic arterial compartments of the blood and vascular wall. The former is the source of numerous biological, chemical, and physical mechanisms that are more commonly observed in tissue, lumen, and DES. As a result, universalizing bio-relevant apparatus, suitable for liberation testing of such complex implants is difficult. This article aims to provide a comprehensive review of the methods used for in vitro release testing of DESs. Aspects related to the correlation of the release profiles in the cases of in vitro and in vivo are also addressed. Full article
(This article belongs to the Special Issue Functional Polymeric Biomaterial)
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