Extraction of Antioxidant Compounds for Pharmaceutical Analysis

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 1707

Special Issue Editor


E-Mail Website
Guest Editor
Department of Chromatographic Methods, Maria Curie-Skłodowska University, 20-031 Lublin, Poland
Interests: antioxidant properties; chromatography; sample preparation; food chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The extraction of antioxidant compounds plays a pivotal role in pharmaceutical analysis, enabling the identification, characterization, and quantification of these crucial bioactive substances. Antioxidants are vital for their ability to neutralize harmful free radicals and protect against oxidative damage, making them essential for developing therapeutic agents. Advances in extraction techniques specifically tailored for antioxidant compounds in pharmaceutical analysis are very important. From traditional solvent extraction methods to innovative approaches, such as solid-phase extraction and supercritical fluid extraction, researchers continuously strive to optimize extraction efficiency, selectivity, and sustainability. By improving the extraction of antioxidant compounds, this field aims to enhance the quality control, understanding, and utilization of pharmaceutical formulations, ultimately promoting better healthcare outcomes.

This Special Issue aims to showcase the latest advances in extraction techniques that are specifically designed for antioxidant compounds in pharmaceutical analysis. Whether your research focuses on traditional solvent extraction, solid-phase extraction, supercritical fluid extraction, or any other innovative approach, we encourage you to share your valuable insights and findings. Through contributions to this Special Issue, we hope to advance extraction methodologies, improving the identification, characterization, and quantification of antioxidant compounds in pharmaceutical formulations. We look forward to receiving your contributions and fostering meaningful discussions in this important area of research.

Dr. Małgorzata Olszowy-Tomczyk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traditional extraction techniques
  • assisted extraction techniques
  • antioxidant compounds
  • natural products
  • phytochemistry
  • chromatographic analysis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 753 KiB  
Article
Impact of Drying Method and Solvent Extraction on Ethiopian Verbascum sinaiticum (Qetetina) Leaves: Metabolite Profiling and Evaluation of Antioxidant Capacity
by Alemu Belay Legesse, Shimelis Admassu Emire, Debebe Worku Dadi, Minbale Gashu Tadesse, Timilehin Martins Oyinloye and Won Byong Yoon
Processes 2024, 12(5), 914; https://doi.org/10.3390/pr12050914 - 29 Apr 2024
Cited by 1 | Viewed by 1334
Abstract
The aim of this study was to evaluate the effects of different drying methods on bioactive compounds and to analyze their composition in Verbascum sinaiticum (V. sinaiticum) leaf extracts using UHPLC-ESI-QTOF-MS/MS. V. sinaiticum is traditionally used as an herbal medicine, yet [...] Read more.
The aim of this study was to evaluate the effects of different drying methods on bioactive compounds and to analyze their composition in Verbascum sinaiticum (V. sinaiticum) leaf extracts using UHPLC-ESI-QTOF-MS/MS. V. sinaiticum is traditionally used as an herbal medicine, yet it has undergone limited scientific investigations regarding its secondary metabolites. V. sinaiticum leaves were dried using oven dryers at 50 °C, 60 °C, and 70 °C, as well as a freeze dryer. The leaves were then extracted using 50% and 70% aqueous ethanol and 100% aqueous solutions. The results showed that the highest contents of TPC and TFC were observed when 70% aqueous ethanol was used during freeze drying, reaching 181.73 mg GAE/g dw and 78.57 mg CE/g dw, respectively. The strongest correlations were observed between the TFC and DPPH radical scavenging activity (0.9082), followed by TPC and ABTS assays (0.8933) and TPC and DPPH (0.8272). In the FTIR analysis, freeze drying exhibited a lower intensity of the phenolic -OH functional groups, contrasting with significant denaturation observed during oven drying at 70 °C. Metabolite analysis identified 29 compounds in V. sinaiticum leaves, further confirming the presence of 14 phenolic and flavonoid compounds, including kaempferol, catechin, gallic acid, and myricetin derivatives, consistent with the experimentally observed antioxidant capacity. This study highlights the impact of drying methods on the bioactive composition of V. sinaiticum and underscores its potential as a source of antioxidants for food, nutraceutical, and pharmaceutical applications. Full article
(This article belongs to the Special Issue Extraction of Antioxidant Compounds for Pharmaceutical Analysis)
Show Figures

Figure 1

Back to TopTop