Model-Based Design of Experiments for Model Identification: New Challenges and Unconventional Applications

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Process Control and Monitoring".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 4862

Special Issue Editors


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Guest Editor
Department Chemical Engineering, University College London, Torrington Pl, London WC1E 7JE, UK
Interests: optimal experimental design; model identification; kinetic and pharmacokinetic modelling; machine-learning-assisted model building

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Guest Editor
Automation & Computer Sciences Department, Harz University of Applied Sciences, 38855 Wernigerode, Germany
Interests: optimal experimental design; process systems engineering; sensitivity and uncertainty analysis
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Special Issue Information

Dear Colleagues,

Model-based design of experiments (MBDoE) techniques are an effective tool to optimally design a set of experiments when the purpose is to develop reliable, predictive models of a process in the quickest, safest and most efficient way. The goal of MBDoE is to identify the set of model equations describing the system (design for model discrimination) and/or to precisely estimate the set of model parameters (design for improving parameter precision). The effectiveness of MBDoE techniques has been demonstrated in numerous applications in industry and academia and in a wide range of research fields, spanning from system biology to energy systems, to food and reaction engineering, to automation and control.

Although there are many exciting developments in this research area, there are also several challenges which are still unresolved. First of all, MBDoE techniques rely on the prediction of experimental information using the model itself. Factors such as model mismatch, model sloppiness or the presence of disturbances acting on the experimental system can severely affect the identification procedure and lead to the execution of suboptimal or even unfeasible experiments. Secondly, MBDoE applications are often applied to systems with a limited number of parameters or variables, and this limits the applicability to large systems of industrial interest. Finally, in the automation area, online model identification algorithms have been proposed in literature, but their practical applicability is still limited.    

This Special Issue will highlight novel research in the field of optimal experimental design for model identification investigating methodological and/or practical aspects related to MBDoE. Recent advances in MBDoE under model uncertainty and/or novel developments of MBDoE techniques in the context of automation and control engineering would be of great interest in this issue. Furthermore, we particularly welcome studies investigating unconventional and new applications of MBDoE across sectors.

Dr. Federico Galvanin
Dr. René Schenkendorf
Guest Editors

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Keywords

  • model-based design of experiments
  • model identification
  • optimal experimental design
  • model discrimination
  • parameter estimation
  • robust experimental design
  • experimental design under uncertainty
  • online design of experiments
  • adaptive experimental design
  • optimal input design

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Published Papers (1 paper)

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25 pages, 1665 KiB  
Article
Model-Based Design of Experiments for High-Dimensional Inputs Supported by Machine-Learning Methods
by Philipp Seufert, Jan Schwientek and Michael Bortz
Processes 2021, 9(3), 508; https://doi.org/10.3390/pr9030508 - 11 Mar 2021
Cited by 5 | Viewed by 2960
Abstract
Algorithms that compute locally optimal continuous designs often rely on a finite design space or on the repeated solution of difficult non-linear programs. Both approaches require extensive evaluations of the Jacobian Df of the underlying model. These evaluations are a heavy computational [...] Read more.
Algorithms that compute locally optimal continuous designs often rely on a finite design space or on the repeated solution of difficult non-linear programs. Both approaches require extensive evaluations of the Jacobian Df of the underlying model. These evaluations are a heavy computational burden. Based on the Kiefer-Wolfowitz Equivalence Theorem, we present a novel design of experiments algorithm that computes optimal designs in a continuous design space. For this iterative algorithm, we combine an adaptive Bayes-like sampling scheme with Gaussian process regression to approximate the directional derivative of the design criterion. The approximation allows us to adaptively select new design points on which to evaluate the model. The adaptive selection of the algorithm requires significantly less evaluations of Df and reduces the runtime of the computations. We show the viability of the new algorithm on two examples from chemical engineering. Full article
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