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Journals
Processes
Special Issues
Application and Development of Disease Diagnosis Microbiology Technology
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Application and Development of Disease Diagnosis Microbiology Technology

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 22805

Special Issue Editors

Dr. Shao-Wen Hung

E-Mail Website
Guest Editor
Division of Animal Industry, Animal Technology Research Center, Agricultural Technology Research Institute, Hsinchu City 300-110, Taiwan
Interests: fish and shellfish immunology; oncology and cancer medicine; veterinary medicine and immunology; fish diseases and therapy; flow cytometry; experimental animal; animal welfare; epilepsy
Special Issues, Collections and Topics in MDPI journals
Dr. Chung-Lun Lu

E-Mail Website
Guest Editor
Aquatic Technology Research Center, Agricultural Technology Research Institute, Hsinchu City 300-110, Taiwan
Interests: fish diseases and therapy; beneficial feed additives; aquaculture; acute and chronic toxicity tests of aquatic animals
Special Issues, Collections and Topics in MDPI journals
Dr. Tseng-Ting Kao

E-Mail Website
Guest Editor
Division of Animal Technology, Animal Technology Research Center, Agricultural Technology Research Institute, Hsinchu City 300-110, Taiwan
Interests: aging; disease animal model; dermatology and dermatitis; arthritis; folate metabolism; oxidative stress; inflammation; intestinal microbiota; alternatives to animal testing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Technological microbiology is an important issue today. This technological microbiology was incorporated with biotechnological techniques that allowed the rapid identification of new molecules and microorganisms or even the genetic improvement of known microorganisms. Commonly, the participation of microorganisms in the generation of medical products or services involves four distinct aspects, i.e., disease control, vaccine production, antibiotic production, and biotherapeutic production. In this Special Issue, the application and development of disease diagnosis microbiology technology will be discussed in the disease control field in detail.

Dr. Shao-Wen Hung
Dr. Chung-Lun Lu
Dr. Tseng-Ting Kao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • application
  • development
  • disease diagnosis
  • microbiology technology
  • microorganism

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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13 pages, 4162 KiB  
Article
Bacillus coagulans BACO-17 Alone or in Combination with Galacto-Oligosaccharide Ameliorates Salmonella-Induced Diarrhea and Intestinal Inflammation
by Min-Zi Wu, Tsai-Chien Sun, Yu-Wen Huang, Yi-Ching Wu, Wei-Jen Chen, Hui-Fang Chu, Cheng-Yen Liu and Chi-Fai Chau
Processes 2022, 10(10), 2123; https://doi.org/10.3390/pr10102123 - 19 Oct 2022
Cited by 4 | Viewed by 4973
Abstract
In this study, a diarrhea model was established by exposing rats to appropriate antibiotics and Salmonella. After an in vitro screening of prebiotics, fructo-oligosaccharide and galacto-oligosaccharide (GOS) were selected; their synbiotic potential and ability to ameliorate diarrhea symptoms and intestinal inflammation with [...] Read more.
In this study, a diarrhea model was established by exposing rats to appropriate antibiotics and Salmonella. After an in vitro screening of prebiotics, fructo-oligosaccharide and galacto-oligosaccharide (GOS) were selected; their synbiotic potential and ability to ameliorate diarrhea symptoms and intestinal inflammation with Bacillus coagulans BACO-17 were evaluated in vivo. After a 27-day feeding experiment including antibiotic intervention and Salmonella infection, it was found that using B. coagulans BACO-17 alone and in combination with GOS as a synbiotic could render a better recovery by lowering diarrhea indexes by 26.9% and 18.7%, respectively. Compared with the negative control, the administration of this synbiotic mixture resulted in the most significant increase in fecal concentrations of total short-chain fatty acids (about 2-fold higher), with a promising improvement in disrupted gut microbial balance. It was worth noting that the administration of B. coagulans BACO-17 alone or in combination with GOS effectively reduced intestinal inflammation (27–31%) and mucosal necrosis (82%) over the negative control. These results suggested that B. coagulans BACO-17 and GOS could be exploited as a promising synbiotic mixture to relieve intestinal inflammatory diseases and improve gut health. Full article
(This article belongs to the Special Issue Application and Development of Disease Diagnosis Microbiology Technology)
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13 pages, 4749 KiB  
Article
The Inhibitory Activity of Citral against Malassezia furfur
by Yi-Tsz Liu, Meng-Hwan Lee, Yin-Shen Lin and Wen-Lin Lai
Processes 2022, 10(5), 802; https://doi.org/10.3390/pr10050802 - 19 Apr 2022
Cited by 1 | Viewed by 4344
Abstract
The lipophilic yeast Malassezia furfur, is a member of the cutaneous commensal microbiota and is associated with several chronic diseases such as dandruff, pityriasis versicolor, folliculitis, and seborrheic dermatitis, that are often difficult to treat with current therapies. The development of alternatively [...] Read more.
The lipophilic yeast Malassezia furfur, is a member of the cutaneous commensal microbiota and is associated with several chronic diseases such as dandruff, pityriasis versicolor, folliculitis, and seborrheic dermatitis, that are often difficult to treat with current therapies. The development of alternatively effective antifungal therapies is therefore of paramount importance. In this study, we investigated the treatment effect of citral on M. furfur. The minimal inhibitory concentration of citral for M. furfur was 200 μg/mL, and the minimal fungicidal concentration was 300 μg/mL. Citral significantly increased the proportion of yeast cells to mycelial forms 2.6-fold. Phosphatidylserine externalization, DNA fragmentation, and metacaspase activation supported a citral-induced apoptosis in M. furfur. Moreover, citral at sub-minimum inhibitory concentrations reduced the invasion of M. furfur in HaCaT keratinocytes. Finally, we demonstrated that citral inhibited IL-6 and TLR-2 expression and enhanced HBD-2 and TSLP expression in M. furfur-infected HaCaT keratinocytes. These results showed that citral has antifungal activity at high concentrations and can decrease the infection of M. furfur by modulating the keratinocyte immune responses at low concentrations. Our results suggest that citral is a potential candidate for topical therapeutic application for M. furfur-associated human skin diseases. Full article
(This article belongs to the Special Issue Application and Development of Disease Diagnosis Microbiology Technology)
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Review

Jump to: Research

20 pages, 4394 KiB  
Review
Aflatoxins: Source, Detection, Clinical Features and Prevention
by Solomon Abrehame, Valsa Remony Manoj, Merry Hailu, Yu-Yi Chen, Yu-Chun Lin and Yen-Po Chen
Processes 2023, 11(1), 204; https://doi.org/10.3390/pr11010204 - 9 Jan 2023
Cited by 19 | Viewed by 12404
Abstract
The most potent mycotoxin, aflatoxins are the secondary metabolite produced by fungi, especially Aspergillus, and have been found to be ubiquitous, contaminating cereals, crops, and even milk and causing major health and economic issues in some countries due to poor storage, substandard [...] Read more.
The most potent mycotoxin, aflatoxins are the secondary metabolite produced by fungi, especially Aspergillus, and have been found to be ubiquitous, contaminating cereals, crops, and even milk and causing major health and economic issues in some countries due to poor storage, substandard management, and lack of awareness. Different aspects of the toxin are reviewed here, including its structural biochemistry, occurrence, factors conducive to its contamination and intoxication and related clinical features, as well as suggested preventive and control strategies and detection methods. Full article
(This article belongs to the Special Issue Application and Development of Disease Diagnosis Microbiology Technology)
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