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Advancements in Microfluidic Technologies and BioMEMS
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Advancements in Microfluidic Technologies and BioMEMS

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 6793

Special Issue Editors

Prof. Dr. D. Marshall Porterfield

E-Mail Website
Guest Editor
Agricultural & Biological Engineering Department, Purdue University, West Lafayette, IN, USA
Interests: bioastronautics; biophysics; space biology; gravitational biology; space agriculture; lunar agriculture
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Kwang W. Oh

E-Mail Website
Guest Editor
1. Sensors and MicroActuators Learning Lab (SMALL), Department of Electrical Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA
2. Department of Biomedical Engineering, University at Buffalo, State University of New York (SUNY-Buffalo), Buffalo, NY 14260, USA
Interests: bioMEMS; lab-on-a-chip (LOC); microfluidics; droplet-based microfluidics; blood separation; micro PCR; micro SERS; sensors for LOC
Special Issues, Collections and Topics in MDPI journals
Dr. Christabel Tan

E-Mail Website
Guest Editor
School of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK
Interests: microfluidics; biosensors; optical sensors; chemical sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are witnessing a remarkable era of innovation in the field of microfluidic technologies and BioMEMS, shaping the future of biomedical research and applications. The integration of advanced microfabrication techniques with biological sciences has led to the emergence of novel platforms like the lab-on-a-chip and organ-on-a-chip, revolutionizing our approach towards disease modeling, drug development, and personalized medicine. This Special Issue, "Advancements in Microfluidic Technologies and BioMEMS", aims to showcase cutting-edge research and developments in this dynamic field. 

We invite contributions that highlight the latest advancements, challenges, and future perspectives in microfluidics and BioMEMS. Submissions can range from technical papers and industrial case studies to comprehensive review articles. We are particularly interested in works focusing on, but not limited to, the following areas: 

  • Development and application of organ-on-a-chip platforms;
  • Innovations in lab-on-a-chip technologies for biomedical applications;
  • Integration of microfluidics with point-of-care diagnostics;
  • Advancements in microfabrication techniques for BioMEMS;
  • Personalized medicine approaches utilizing microfluidic devices;
  • Advances in sensing technology for the lab-on-a-chip.

Your contributions will be pivotal in shaping the understanding and application of microfluidic technologies and BioMEMS in the biomedical field. We look forward to your valuable insights and discoveries.

Prof. Dr. D. Marshall Marshall Porterfield
Prof. Dr. Kwang W. Oh
Dr. Christabel Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • BioMEMS
  • lab-on-a-chip
  • organ-on-a-chip
  • point-of-care technologies

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Published Papers (3 papers)

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Research

10 pages, 4545 KiB  
Article
Magnetic Stirring Device for Limiting the Sedimentation of Cells inside Microfluidic Devices
by Sebastian Cremaschini, Noemi Torriero, Chiara Maceri, Maria Poles, Sarah Cleve, Beatrice Crestani, Alessio Meggiolaro, Matteo Pierno, Giampaolo Mistura, Paola Brun and Davide Ferraro
Sensors 2024, 24(15), 5014; https://doi.org/10.3390/s24155014 - 2 Aug 2024
Cited by 1 | Viewed by 998
Abstract
In experiments considering cell handling in microchannels, cell sedimentation in the storage container is a key problem because it affects the reproducibility of the experiments. Here, a simple and low-cost cell mixing device (CMD) is presented; the device is designed to prevent the [...] Read more.
In experiments considering cell handling in microchannels, cell sedimentation in the storage container is a key problem because it affects the reproducibility of the experiments. Here, a simple and low-cost cell mixing device (CMD) is presented; the device is designed to prevent the sedimentation of cells in a syringe during their injection into a microfluidic channel. The CMD is based on a slider crank device made of 3D-printed parts that, combined with a permanent magnet, actuate a stir bar placed into the syringe containing the cells. By using A549 cell lines, the device is characterized in terms of cell viability (higher than 95%) in different mixing conditions, by varying the oscillation frequency and the overall mixing time. Then, a dedicated microfluidic experiment is designed to evaluate the injection frequency of the cells within a microfluidic chip. In the presence of the CMD, a higher number of cells are injected into the microfluidic chip with respect to the static conditions (2.5 times), proving that it contrasts cell sedimentation and allows accurate cell handling. For these reasons, the CMD can be useful in microfluidic experiments involving single-cell analysis. Full article
(This article belongs to the Special Issue Advancements in Microfluidic Technologies and BioMEMS)
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15 pages, 4084 KiB  
Article
Nucleic Acid Target Sensing Using a Vibrating Sharp-Tip Capillary and Digital Droplet Loop-Mediated Isothermal Amplification (ddLAMP)
by Bethany J. Fike, Kathrine Curtin and Peng Li
Sensors 2024, 24(13), 4266; https://doi.org/10.3390/s24134266 - 30 Jun 2024
Viewed by 4328
Abstract
Nucleic acid tests are key tools for the detection and diagnosis of many diseases. In many cases, the amplification of the nucleic acids is required to reach a detectable level. To make nucleic acid amplification tests more accessible to a point-of-care (POC) setting, [...] Read more.
Nucleic acid tests are key tools for the detection and diagnosis of many diseases. In many cases, the amplification of the nucleic acids is required to reach a detectable level. To make nucleic acid amplification tests more accessible to a point-of-care (POC) setting, isothermal amplification can be performed with a simple heating source. Although these tests are being performed in bulk reactions, the quantification is not as accurate as it would be with digital amplification. Here, we introduce the use of the vibrating sharp-tip capillary for a simple and portable system for tunable on-demand droplet generation. Because of the large range of droplet sizes possible and the tunability of the vibrating sharp-tip capillary, a high dynamic range (~2 to 6000 copies/µL) digital droplet loop-mediated isothermal amplification (ddLAMP) system has been developed. It was also noted that by changing the type of capillary on the vibrating sharp-tip capillary, the same mechanism can be used for simple and portable DNA fragmentation. With the incorporation of these elements, the present work paves the way for achieving digital nucleic acid tests in a POC setting with limited resources. Full article
(This article belongs to the Special Issue Advancements in Microfluidic Technologies and BioMEMS)
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15 pages, 3372 KiB  
Article
A High-Throughput Circular Tumor Cell Sorting Chip with Trapezoidal Cross Section
by Shijie Lu, Ding Ma and Xianqiang Mi
Sensors 2024, 24(11), 3552; https://doi.org/10.3390/s24113552 - 31 May 2024
Cited by 1 | Viewed by 950
Abstract
Circulating tumor cells are typically found in the peripheral blood of patients, offering a crucial pathway for the early diagnosis and prediction of cancer. Traditional methods for early cancer diagnosis are inefficient and inaccurate, making it difficult to isolate tumor cells from a [...] Read more.
Circulating tumor cells are typically found in the peripheral blood of patients, offering a crucial pathway for the early diagnosis and prediction of cancer. Traditional methods for early cancer diagnosis are inefficient and inaccurate, making it difficult to isolate tumor cells from a large number of cells. In this paper, a new spiral microfluidic chip with asymmetric cross-section is proposed for rapid, high-throughput, label-free enrichment of CTCs in peripheral blood. A mold of the desired flow channel structure was prepared and inverted to make a trapezoidal cross-section using a micro-nanotechnology process of 3D printing. After a systematic study of how flow rate, channel width, and particle concentration affect the performance of the device, we utilized the device to simulate cell sorting of 6 μm, 15 μm, and 25 μm PS (Polystyrene) particles, and the separation efficiency and separation purity of 25 μm PS particles reached 98.3% and 96.4%. On this basis, we realize the enrichment of a large number of CTCs in diluted whole blood (5 mL). The results show that the separation efficiency of A549 was 88.9% and the separation purity was 96.4% at a high throughput of 1400 μL/min. In conclusion, we believe that the developed method is relevant for efficient recovery from whole blood and beneficial for future automated clinical analysis. Full article
(This article belongs to the Special Issue Advancements in Microfluidic Technologies and BioMEMS)
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