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Micromachines
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Biomedical Microfluidic Devices 2021
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Biomedical Microfluidic Devices 2021

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 20247

Special Issue Editor

Prof. Dr. Kwang W. Oh

E-Mail Website
Guest Editor
1. Sensors and MicroActuators Learning Lab (SMALL), Department of Electrical Engineering, The State University of New York at Buffalo, Buffalo, NY 14260, USA
2. Department of Biomedical Engineering, University at Buffalo, State University of New York (SUNY-Buffalo), Buffalo, NY 14260, USA
Interests: bioMEMS; lab-on-a-chip (LOC); microfluidics; droplet-based microfluidics; blood separation; micro PCR; micro SERS; sensors for LOC
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

One of the greatest challenges of researchers using microfluidics is to develop novel microfluidic devices for the enhancement of their capabilities in biology and medical research. Many biomedical microfluidic devices have been miniaturized to replace conventional bioassays and diagnostics, featuring high bioassay performance, high system integration, improved potential for automation and control, small volume of samples and reagents, reduced cost, greater reliability and sensitivity, disposability and shorter bioassay times.

In this Special Issue, we solicit review articles and original research papers addressing technical challenges on developing microfluidic devices for biomedical and diagnostics applications. The papers can cover all aspects of biomedical microfluidic devices including, but not limited to, recent developments in the following areas: biomedical microfluidic devices; DNA, protein, cell, organism, tissue and organ on a chip; diagnostics and theranostics; drug discovery and delivery; lab on a chip (LOC); manipulation of biomolecules and biofluids; micro total analysis (mTAS); miniaturization of bioassays; and point of care (POC) devices.

Authors are invited to contact the guest editors prior to submission if they are uncertain whether their work falls within the general scope of this Special Issue on "Biomedical Microfluidic Devices 2021".

Prof. Dr. Kwang W. Oh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical microfluidic devices
  • diagnostics
  • DNA, protein, cell, organism, tissue and organ on chip drug discovery and delivery
  • lab on a chip (LOC)
  • manipulation of biomolecules and biofluids
  • micro total analysis (mTAS)
  • miniaturization of bioassays
  • point
  • theranostics

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Published Papers (4 papers)

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Research

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22 pages, 40848 KiB  
Article
Fibroblast Derived Skin Wound Healing Modeling on Chip under the Influence of Micro-Capillary Shear Stress
by Sharda Gupta, Lavish Patel, Kunal Mitra and Arindam Bit
Micromachines 2022, 13(2), 305; https://doi.org/10.3390/mi13020305 - 16 Feb 2022
Cited by 10 | Viewed by 3611
Abstract
Fibroblast cell migration plays a crucial role in the wound-healing process. Hence, its quantitative investigation is important to understand the mechanism of the wound-healing process. The dynamic nature of the wound-healing process can be easily implemented using a microfluidic-based wound-healing assay. This work [...] Read more.
Fibroblast cell migration plays a crucial role in the wound-healing process. Hence, its quantitative investigation is important to understand the mechanism of the wound-healing process. The dynamic nature of the wound-healing process can be easily implemented using a microfluidic-based wound-healing assay. This work presented the use of a microfluidics device to simulate traumatic wounds on fibroblast cell monolayers by utilizing trypsin flow and PDMS barrier. In this study, a microfluidic chip with a transparent silk film is reported. The placement of film provides 3D cell culture conditions that mimic a 3D extracellular matrix (ECM) like environment and allows real-time monitoring of cells. A numerical study was conducted to evaluate the influence of dynamic medium-induced shear stress on the base and wall of the microchannel. This could facilitate the optimization of the inlet flow conditions of the media in the channel. At the same time, it could help in identifying stress spots in the channel. The scaffolds were placed in those spots for evaluating the influence of shear forces on the migratory behavior of fibroblast cells. The in vitro microfluidic assembly was then evaluated for cell migration under the influence of external shear forces during the wound-healing phenomena. A faster wound healing was obtained at the end of 24 h of the creation of the wound in the presence of optimal shear stress. On increasing the shear stress beyond a threshold limit, it dissociates fibroblast cells from the surface of the substrate, thereby decelerating the wound-healing process. The above phenomena were transformed in both coplanar microfluidics surfaces (by realizing in the multichannel interlinked model) and transitional microfluidics channels (by realizing in the sandwich model). Full article
(This article belongs to the Special Issue Biomedical Microfluidic Devices 2021)
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15 pages, 6288 KiB  
Article
An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution
by Anyang Wang, Samaneh Moghadasi Boroujeni, Philip J. Schneider, Liam B. Christie, Kyle A. Mancuso, Stelios T. Andreadis and Kwang W. Oh
Micromachines 2021, 12(5), 482; https://doi.org/10.3390/mi12050482 - 23 Apr 2021
Cited by 7 | Viewed by 5328
Abstract
We propose an integrated serial dilution generator utilizing centrifugal force with a degassed polydimethylsiloxane (PDMS) microfluidic device. Using gas-soluble PDMS as a centrifugal microfluidic device material, the sample can be dragged in any arbitrary direction using vacuum-driven force, as opposed to in a [...] Read more.
We propose an integrated serial dilution generator utilizing centrifugal force with a degassed polydimethylsiloxane (PDMS) microfluidic device. Using gas-soluble PDMS as a centrifugal microfluidic device material, the sample can be dragged in any arbitrary direction using vacuum-driven force, as opposed to in a single direction, without adding further actuation components. The vacuum-driven force allows the device to avoid the formation of air bubbles and exhibit high tolerance in the surface condition. The device was then used for sample metering and sample transferring. In addition, centrifugal force was used for sample loading and sample mixing. In this study, a series of ten-fold serial dilutions ranging from 100 to 10−4 with about 8 μL in each chamber was achieved, while the serial dilution ratio and chamber volume could easily be altered by changing the geometrical designs of the device. As a proof of concept of our hybrid approach with the centrifugal and vacuum-driven forces, ten-fold serial dilutions of a cDNA (complementary DNA) sample were prepared using the device. Then, the diluted samples were collected by fine needles and subject to a quantitative polymerase chain reaction (qPCR), and the results were found to be in good agreement with those for samples prepared by manual pipetting. Full article
(This article belongs to the Special Issue Biomedical Microfluidic Devices 2021)
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11 pages, 3708 KiB  
Article
Surface Modification of PDMS-Based Microfluidic Devices with Collagen Using Polydopamine as a Spacer to Enhance Primary Human Bronchial Epithelial Cell Adhesion
by Mohammadhossein Dabaghi, Shadi Shahriari, Neda Saraei, Kevin Da, Abiram Chandiramohan, Ponnambalam Ravi Selvaganapathy and Jeremy A. Hirota
Micromachines 2021, 12(2), 132; https://doi.org/10.3390/mi12020132 - 26 Jan 2021
Cited by 33 | Viewed by 5976
Abstract
Polydimethylsiloxane (PDMS) is a silicone-based synthetic material used in various biomedical applications due to its properties, including transparency, flexibility, permeability to gases, and ease of use. Though PDMS facilitates and assists the fabrication of complicated geometries at micro- and nano-scales, it does not [...] Read more.
Polydimethylsiloxane (PDMS) is a silicone-based synthetic material used in various biomedical applications due to its properties, including transparency, flexibility, permeability to gases, and ease of use. Though PDMS facilitates and assists the fabrication of complicated geometries at micro- and nano-scales, it does not optimally interact with cells for adherence and proliferation. Various strategies have been proposed to render PDMS to enhance cell attachment. The majority of these surface modification techniques have been offered for a static cell culture system. However, dynamic cell culture systems such as organ-on-a-chip devices are demanding platforms that recapitulate a living tissue microenvironment’s complexity. In organ-on-a-chip platforms, PDMS surfaces are usually coated by extracellular matrix (ECM) proteins, which occur as a result of a physical and weak bonding between PDMS and ECM proteins, and this binding can be degraded when it is exposed to shear stresses. This work reports static and dynamic coating methods to covalently bind collagen within a PDMS-based microfluidic device using polydopamine (PDA). These coating methods were evaluated using water contact angle measurement and atomic force microscopy (AFM) to optimize coating conditions. The biocompatibility of collagen-coated PDMS devices was assessed by culturing primary human bronchial epithelial cells (HBECs) in microfluidic devices. It was shown that both PDA coating methods could be used to bind collagen, thereby improving cell adhesion (approximately three times higher) without showing any discernible difference in cell attachment between these two methods. These results suggested that such a surface modification can help coat extracellular matrix protein onto PDMS-based microfluidic devices. Full article
(This article belongs to the Special Issue Biomedical Microfluidic Devices 2021)
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Review

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19 pages, 3175 KiB  
Review
Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening
by Pei Zhao, Jianchun Wang, Chengmin Chen, Jianmei Wang, Guangxia Liu, Krishnaswamy Nandakumar, Yan Li and Liqiu Wang
Micromachines 2022, 13(2), 200; https://doi.org/10.3390/mi13020200 - 27 Jan 2022
Cited by 11 | Viewed by 3998
Abstract
Microfluidic technology has been highly useful in nanovolume sample preparation, separation, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on [...] Read more.
Microfluidic technology has been highly useful in nanovolume sample preparation, separation, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations. Full article
(This article belongs to the Special Issue Biomedical Microfluidic Devices 2021)
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