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Green Extraction Techniques of Bioactive Compounds from Natural Sources
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Green Extraction Techniques of Bioactive Compounds from Natural Sources

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2003

Special Issue Editors

Dr. Liliana Mihalcea

E-Mail Website
Guest Editor
Faculty of Food Science and Engineering, Dunarea de Jos University of Galati, 47 Domnească Street, 800008 Galați, Romania
Interests: green extraction techniques; biologically active compounds from natural sources; food drying; valorisation of extraction byproducts for food formulation
Prof. Dr. Mona Elena Popa

E-Mail Website
Guest Editor
Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Bulevard, 1 Bucharest, Romania
Interests: food safety; food preservation; food packaging; food waste valorization; green extraction techniques of natural bioactive compounds as antimicrobials; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Green extraction techniques have been widely used in recent years due to the major sustainable goals established by authorities to valorize wastes and by-products from the agricultural and food industries. The Special Issue will focus on the evaluation of green extraction technologies to sustain the circular economy concept by using the waste agri-food by-products to create value-added products. The obtained extracts are a source of bioactive compounds, including phytomolecules with chemical and functional profiles influenced by extraction process and conditions, and evaluated in different in vitro and in vivo systems.

This Special Issue on "Green Extraction Techniques of Bioactive Compounds From Natural Sources" aims to present novel advances in green extraction methods, and the main topics include, but are not limited to, the following:

  • The circular economy concept through the strategies of wastes and by-products from the agri-food sector;
  • Green extraction methods for the recovery of bioactive compounds;
  • Chromatography methods for determining the quality and safety of the extracts;
  • The development of different value-added food products, new herbal drugs or cosmetic products;
  • Analytical methods for demonstrating the phyto-chemical and nutritional value of new products.

We cordially invite authors to contribute original research articles and reviews that provide innovative information on green extraction techniques of bioactive compounds from natural sources.

Dr. Liliana Mihalcea
Prof. Dr. Mona Elena Popa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural sources
  • bioactive compounds
  • supercritical extraction
  • subcritical water extraction
  • chromatography
  • spectrometry
  • ultrasound-assisted extraction
  • microwave-assisted extraction
  • pressurized liquid extraction
  • enzyme-assisted extraction
  • bioeconomy

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Published Papers (2 papers)

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Research

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17 pages, 2691 KiB  
Article
Phytochemical Profile Screening and Selected Bioactivity of Myrtus communis Berries Extracts Obtained from Ultrasound-Assisted and Supercritical Fluid Extraction
by Ilir Mërtiri, Gigi Coman, Mihaela Cotârlet, Mihaela Turturică, Nicoleta Balan, Gabriela Râpeanu, Nicoleta Stănciuc and Liliana Mihalcea
Separations 2025, 12(1), 8; https://doi.org/10.3390/separations12010008 - 3 Jan 2025
Viewed by 563
Abstract
This research paper investigates the phytochemical profile, antioxidant activity, antidiabetic potential, and antibacterial activity of Myrtus communis berries. Two extraction methods were employed to obtain the extracts: solid–liquid ultrasound-assisted extraction (UAE) and supercritical fluid extraction (SFE). The extracts were characterized using spectrophotometric methods [...] Read more.
This research paper investigates the phytochemical profile, antioxidant activity, antidiabetic potential, and antibacterial activity of Myrtus communis berries. Two extraction methods were employed to obtain the extracts: solid–liquid ultrasound-assisted extraction (UAE) and supercritical fluid extraction (SFE). The extracts were characterized using spectrophotometric methods and Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). The UAE extract exhibited higher total flavonoid and anthocyanin content, while the SFE extract prevailed in total phenolic content and antioxidant activity in the DPPH radical screening assay. RP-HPLC characterization identified and quantified several polyphenolic compounds. In the UAE extract, epigallocatechin was found in a concentration of 2656.24 ± 28.15 µg/g dry weight (DW). In the SFE extract, cafestol was the identified compound with the highest content at a level of 29.65 ± 0.03 µg/g DW. Both extracts contained several anthocyanin compounds, including cyanidin 3-O-glucoside chloride, cyanidin-3-O-rutinoside chloride, malvidin-3-O-glucoside chloride, pelargonidin 3-O-glucoside chloride, peonidin 3-O-glucoside chloride, and peonidin-3-O-rutinoside chloride. The antidiabetic potential was evaluated in vitro by measuring the inhibition of α-amylase from porcine pancreas (type I-A). The results highlighted the ability of myrtle berry extracts to inhibit α-amylase enzymatic activity, suggesting its potential as an alternative for controlling postprandial hyperglycemia. The UAE extract showed the lowest IC50 value among the two extracts, with an average of 8.37 ± 0.52 µg/mL DW. The antibacterial activity of the extracts was assessed in vitro against Bacillus spp., Escherichia coli, and Staphylococcus aureus using the disk diffusion method. Both myrtle berry extracts exhibited similar antibacterial activity against the tested bacterial strains. The results support further investigation of myrtle berries extracts as a potential ingredient in functional food formulation, particularly due to its antioxidant, antidiabetic, and antibacterial properties. Full article
(This article belongs to the Special Issue Green Extraction Techniques of Bioactive Compounds from Natural Sources)
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Review

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27 pages, 1465 KiB  
Review
Useful Extracts from Coffee By-Products: A Brief Review
by Krystyna Pyrzynska
Separations 2024, 11(12), 334; https://doi.org/10.3390/separations11120334 - 21 Nov 2024
Viewed by 1017
Abstract
The waste materials generated from the processing of coffee cherries are still rich in several bioactive compounds. Several studies highlight coffee by-products as a valuable source for diverse applications, such as biofuels, biopolymers, biocomposites, and natural antioxidants in food, pharmaceuticals, and cosmetics. The [...] Read more.
The waste materials generated from the processing of coffee cherries are still rich in several bioactive compounds. Several studies highlight coffee by-products as a valuable source for diverse applications, such as biofuels, biopolymers, biocomposites, and natural antioxidants in food, pharmaceuticals, and cosmetics. The development of prospective strategies for the valorization of coffee wastes is a goal of a sustainable and circular bioeconomy, increasing the added value of these wastes and reducing environmental pollution. This brief overview describes the recently proposed procedures for the extraction and recovery of functional ingredients from the diversity of coffee by-products. The comparison between conventional and alternative extraction methods enables one to choose the most suitable techniques for valorizing a given coffee by-product. Full article
(This article belongs to the Special Issue Green Extraction Techniques of Bioactive Compounds from Natural Sources)
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