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Toxics
Special Issues
Endocrine-Disrupting Chemicals and Reproductive Toxicology
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Endocrine-Disrupting Chemicals and Reproductive Toxicology

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 4044

Special Issue Editor

Dr. Michał Hubert Wróbel

E-Mail Website
Guest Editor
Department of Physiology and Toxicology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
Interests: pesticides; endocrine disruptors; environmental toxicology; reproductive disorders; myometrial contractions

Special Issue Information

Dear Colleagues,

Chemical products are indispensable in modern everyday life.  They are a varied and broad group with many different benefits. However, after bioaccumulation in living organisms, they can act as endocrine disruptors and can pose risks to domestic animal or human reproduction.

This Special Issue aims to contribute to novel research on the cellular and molecular mechanisms of endocrine-disrupting chemicals and how they impact reproduction. We encourage the study of currently used chemicals and their metabolites, as well as protection products that are commonly recognized as persistent environmental contaminants and have been banned previously. This can improve their risk assessment, but also potentially aid in finding substances with beneficial effects on reproduction.

Papers may include, but are not limited to, the following topics: the molecular or epigenetic mechanisms behind the toxicity of chemicals; disorders related to the receptivity and further signal transmission of reproductive hormones; in vitro studies; and/or predictive or computational reproductive toxicology approaches.

Authors are invited and welcome to submit original research papers, reviews, short communications, and case reports. 

Dr. Michał Hubert Wróbel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive toxicology
  • endocrine disruptors
  • environmental pollutions
  • parabens
  • pesticides
  • plastic
  • phthalates
  • metals
  • polychlorinated biphenyls
  • polybrominated compounds

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

18 pages, 15397 KiB  
Article
Perinatal Exposure to Glyphosate or a Commercial Formulation Alters Uterine Mechanistic Pathways Associated with Implantation Failure in Rats
by Ailín Almirón, Virginia Lorenz, Jorgelina Varayoud, Milena Durando and María Mercedes Milesi
Toxics 2024, 12(8), 590; https://doi.org/10.3390/toxics12080590 - 14 Aug 2024
Viewed by 714
Abstract
Perinatal exposure to a glyphosate-based herbicide (GBH) or its active ingredient, glyphosate (Gly), has been demonstrated to increase implantation failure in rats. This study investigates potential mechanisms of action, analyzing uterine preparation towards the receptive state. Pregnant Wistar rats (F0) were treated orally [...] Read more.
Perinatal exposure to a glyphosate-based herbicide (GBH) or its active ingredient, glyphosate (Gly), has been demonstrated to increase implantation failure in rats. This study investigates potential mechanisms of action, analyzing uterine preparation towards the receptive state. Pregnant Wistar rats (F0) were treated orally with GBH or Gly (3.8 and 3.9 mg Gly/kg/day, respectively) from gestational day (GD) 9 until weaning. Adult F1 females became pregnant and uterine samples were collected on GD5 (preimplantation period). Histomorphological uterine parameters were assessed. Immunohistochemistry was applied to evaluate cell proliferation and protein expression of estrogen receptors (ERα and ERβ), cell cycle regulators (PTEN, cyclin G1, p27, and IGF1R-α), and the Wnt5a/β-catenin/FOXA2/Lif pathway. Both GBH and Gly females showed increased stromal proliferation, associated with a high expression of ERs. Dysregulation of PTEN and cyclin G1 was also observed in the Gly group. Reduced gland number was observed in both groups, along with decreased expression of Wnt5a/β-catenin/FOXA2/Lif pathway in the glandular epithelium. Overall, GBH and Gly perinatal exposure disrupted intrinsic uterine pathways involved in endometrial proliferation and glandular function, providing a plausible mechanism for glyphosate-induced implantation failure by compromising uterine receptivity. Similar effects between GBH and Gly suggest the active principle mainly drives the adverse outcomes. Full article
(This article belongs to the Special Issue Endocrine-Disrupting Chemicals and Reproductive Toxicology)
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17 pages, 1910 KiB  
Article
Innovative Approach for Human Semen Quality Assessment Based on Volatilomics
by Simonetta Capone, Angiola Forleo, Antonio Vincenzo Radogna, Valentina Longo, Giulia My, Alessandra Genga, Alessandra Ferramosca, Giuseppe Grassi, Flavio Casino, Pietro Siciliano, Tiziana Notari, Sebastiana Pappalardo, Marina Piscopo and Luigi Montano
Toxics 2024, 12(8), 543; https://doi.org/10.3390/toxics12080543 - 27 Jul 2024
Viewed by 1235
Abstract
The volatilome profile of some biofluids (blood, urine, and human semen) identified by Solid-Phase Microextraction–Gas Chromatography/Mass Spectrometry (SPME-GC/MS) and collected from young men living in two high-pollution areas in Italy, i.e., Land of Fires and Valley of Sacco River, have been coupled to [...] Read more.
The volatilome profile of some biofluids (blood, urine, and human semen) identified by Solid-Phase Microextraction–Gas Chromatography/Mass Spectrometry (SPME-GC/MS) and collected from young men living in two high-pollution areas in Italy, i.e., Land of Fires and Valley of Sacco River, have been coupled to sperm parameters obtained by spermiogram analysis to build general multiple regression models. Panels of volatile organic compounds (VOCs) have been selected to optimize the models and used as predictive variables to estimate the different sperm quality parameters (sperm cell concentration, total and progressive motility/immotile cells, total/head/neck/tail morphology anomalies, semen round cell concentration). The results of the multiple linear regression models based on the different subgroups of data joining VOCs from one/two or three biofluids have been compared. Surprisingly, the models based on blood and urine VOCs have allowed an excellent estimate of spermiogram values, paving the way towards a new method of indirect evaluation of semen quality and preventive screening. The significance of VOCs in terms of toxicity and dangerousness was discussed with the support of chemical databases available online. Full article
(This article belongs to the Special Issue Endocrine-Disrupting Chemicals and Reproductive Toxicology)
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18 pages, 2503 KiB  
Article
Reproductive and Developmental Effects of Sex-Specific Chronic Exposure to Dietary Arsenic in Zebrafish (Danio rerio)
by Mahesh Rachamalla, Arash Salahinejad, Vladimir Kodzhahinchev and Som Niyogi
Toxics 2024, 12(4), 302; https://doi.org/10.3390/toxics12040302 - 19 Apr 2024
Cited by 1 | Viewed by 1562
Abstract
The present study investigated the reproductive and developmental effects of sex-specific chronic exposure to dietary arsenic in zebrafish. Adult zebrafish (Danio rerio) were exposed to environmentally realistic doses of arsenic via diet [0 (control; no added arsenic), 30 (low), 60 (medium), [...] Read more.
The present study investigated the reproductive and developmental effects of sex-specific chronic exposure to dietary arsenic in zebrafish. Adult zebrafish (Danio rerio) were exposed to environmentally realistic doses of arsenic via diet [0 (control; no added arsenic), 30 (low), 60 (medium), and 100 (high) μg/g dry weight, as arsenite] for 90 days. Following exposure, arsenic-exposed females from each dietary treatment were mated with control males, and similarly, arsenic-exposed males from each dietary treatment were mated with control females. In females, arsenic exposure resulted in a dose-dependent decrease in reproductive performance (fecundity, fertilization success, and hatching success). Moreover, a dose-dependent increase in developmental toxicity (larval deformities and larval mortality) was observed with maternal exposure to arsenic. In contrast, in males, arsenic exposure also induced similar reproductive and developmental toxicity; however, the adverse effects were mainly evident only in the medium and high dietary arsenic treatment groups. We also examined the sex-specific effects of dietary arsenic exposure on the expression of genes that regulate the hypothalamus–pituitary–gonadal–liver (HPG-L) axis in fish. The gene expression results indicated the downregulation of HPG-L axis genes in females irrespective of the arsenic treatment dose; however, the reduced expression of HPG-L axis genes in males was recorded only in the medium and high arsenic treatment groups. These observations suggest that chronic arsenic exposure in either females or males causes reproductive and developmental toxicity in zebrafish. However, these toxic effects are markedly higher in females than in males. Our results also suggest that arsenic can act as an endocrine disruptor and mediate reproductive and developmental toxicity by disrupting the HPG-L axis in zebrafish. Full article
(This article belongs to the Special Issue Endocrine-Disrupting Chemicals and Reproductive Toxicology)
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