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Toxics
Special Issues
Advances in Chemical Exposure and Environmental Risk
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Advances in Chemical Exposure and Environmental Risk

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1258

Special Issue Editor

Dr. Edmond Sanganyado

E-Mail Website
Guest Editor
Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
Interests: chemical risk; bioaccumulation; dietary exposure; emerging contaminants; marine pollution; environmental risk; biotransformation; non-target analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Synthetic chemicals emitted into the environment now exceed safe limits and threaten the stability of ecosystems. There exist more than 160 million chemicals, of which 350,000 are available commercially. In 2019, a small number of synthetic chemicals with known mechanisms of toxicity contributed to more than 2 million deaths globally. Hence, the full impact of synthetic chemicals on human and ecological health remains unknown.

Addressing this complex challenge requires an accurate, reliable, and robust analysis of the contact between chemical pollutants and human and ecological receptors, the fate and transport of the stressors from their sources, and the potential adverse impacts on the health of humans and the environment. Technological advances have enabled an association to be made between chemical exposure and adverse health outcomes via the integration of multi-omics and high-throughput screening, suspect and non-target analysis or machine learning.

This Special Issue aims to present the latest advances in exposure science and environmental risk studies that mechanistically link chemical exposure to adverse health outcomes in humans and the environment. We are pleased to welcome original research papers, reviews, and short communications that contribute to research on exposure assessment, exposure pathways, novel analytical approaches, human behavior and exposure risk, big data and AI, and metabolomics and biomarkers.

Dr. Edmond Sanganyado
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical exposure
  • metabolomics
  • AI and chemical risk
  • Suspect and non-target analysis
  • non-communicable diseases
  • human biomonitoring
  • environmental risk

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Published Papers (1 paper)

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Research

17 pages, 4413 KiB  
Article
Ameliorative Role of Vitamin C against Cypermethrin Induced Oxidative Stress and DNA Damage in Labeo rohita (Hamilton, 1822) Using Single Cell Gel Electrophoresis
by Sana Ullah, Amina Zuberi, Imdad Ullah and Mahmoud M. Azzam
Toxics 2024, 12(9), 664; https://doi.org/10.3390/toxics12090664 - 12 Sep 2024
Viewed by 942
Abstract
The present study was undertaken to evaluate cypermethrin (CYP)-induced oxidative stress [reactive oxygen species (ROS) and lipid peroxidation (LPO) in gills, muscles, brain, and liver tissues] and DNA damage/genotoxicity (peripheral blood erythrocytes) in a freshwater teleost rohu (Labeo rohita) and the [...] Read more.
The present study was undertaken to evaluate cypermethrin (CYP)-induced oxidative stress [reactive oxygen species (ROS) and lipid peroxidation (LPO) in gills, muscles, brain, and liver tissues] and DNA damage/genotoxicity (peripheral blood erythrocytes) in a freshwater teleost rohu (Labeo rohita) and the protective role of vitamin C. The LC50 of CYP against rohu was found to be 4.5 µg/L in a semi-static culture system through probit analysis. Fingerlings of rohu were distributed into four groups (Group 1st served as a control, fed 35% protein basal diet and was not exposed to CYP; Group 2nd was fed a basal diet and exposed to CYP; Group 3rd and Group 4th were fed diets supplemented with vitamin C at the rate of 100 and 200 mg/kg diet, respectively, and exposed to CYP). Fingerlings were reared on a basal and vitamin C-supplemented diet for 28 days prior to exposure to CYP. The results indicate a time-dependent significant increase in ROS and LPO (indicated by time course increase in TBARS level) as well as DNA damage in terms of number of comets, % DNA in tail, tail moment, tail length, and olive tail moment after exposure to LC50 of CYP. However, statistically comparable results in both Groups 1st and 4th indicate the protective role of vitamin C. The results reveal the effectiveness of vitamin C as a feed additive for countering pesticides toxicity in Labeo rohita. The current study indicates CYP as a potential genotoxicant for fish and classifies SCGE as a reliable and sensitive tool for assessing DNA damage. Full article
(This article belongs to the Special Issue Advances in Chemical Exposure and Environmental Risk)
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