Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.5
3.9
Journals
Toxics
Special Issues
Identification of Toxic Effects of Emerging Chemicals throughout the Reproductive...
share announcement

Identification of Toxic Effects of Emerging Chemicals throughout the Reproductive Process

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 3585

Special Issue Editors

Prof. Dr. Yankai Xia

E-Mail Website
Guest Editor
School of Public Health, Nanjing Medical University, Nanjing 211166, China
Interests: environmental health; reproductive toxicology; emerging contaminants; exposome; metabolome; microbiome; reproductive and developmental toxicity
Special Issues, Collections and Topics in MDPI journals
Dr. Hein Min Tun

E-Mail Website
Guest Editor
Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Interests: environmental health; early life exposome; epidemiology; microbiome in health and disease; host–microbiome interactions
Dr. Rongbin Xu

E-Mail Website
Guest Editor
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Interests: environmental epidemiology; epigenetic epidemiology; climate change; air pollution and health; built environment and health; exposure assessment using machine leaning and spatial and GIS techniques; child and adolescent health; biostatistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, accelerated industrialization and technological innovation have increased the production and consumption of emerging chemicals. These emerging chemicals are not commonly monitored in the environment but have the potential to enter the environment and are continually found in construction materials, drinking water, food, cosmetics, household products, etc. Human biomonitoring studies have shown that people are exposed to various emerging chemicals in daily life, including but not limited to manufactured nanomaterials, flame retardants, new pesticides, and water disinfection byproducts. Some emerging chemicals have been reported to have adverse effects on reproductive health. However, the toxic effects of many emerging chemicals and the biological mechanisms behind them remain unclear.

Therefore, this Special Issue focuses on the identification of the toxic effects of emerging chemicals throughout the whole reproductive process, including reproductive system development, gametogenesis, embryonic development, and fetal growth. Research areas may include but are not limited to the following: exposure assessment of emerging chemicals using human biomonitoring methods, association analysis between emerging chemicals exposure and adverse reproductive outcomes based on human epidemiologic studies, reproductive and developmental toxicity assessment of emerging chemicals using in vitro, ex vivo, or in vivo models.

In this Special Issue, high-quality original articles and reviews are welcomed. We look forward to receiving your contributions.

Prof. Dr. Yankai Xia
Dr. Hein Min Tun
Dr. Rongbin Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging chemicals
  • reproductive toxicology
  • reproductive system disorders
  • exposure assessment
  • risk assessment
  • biological mechanism

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

11 pages, 885 KiB  
Article
Is Polyhexamethylene Guanidine and Oligo(2-(2-Ethoxy) Ethoxyethyl Guanidium Chloride Exposure Related to Gestational Diabetes?
by Hyowon Choi, Nam-Yun Kim, Nalai Kim and Yeon-Soon Ahn
Toxics 2024, 12(12), 841; https://doi.org/10.3390/toxics12120841 - 22 Nov 2024
Viewed by 227
Abstract
This study aims to investigate the association between exposure to toxic indoor chemicals, specifically polyhexamethylene guanidine (PHMG) and oligo(2-(2-ethoxy) ethoxyethyl guanidinium) chloride (PGH), used in humidifier disinfectants, and gestational diabetes mellitus (GDM). We confirmed pregnancy from 2003 to 2017 and identified GDM by [...] Read more.
This study aims to investigate the association between exposure to toxic indoor chemicals, specifically polyhexamethylene guanidine (PHMG) and oligo(2-(2-ethoxy) ethoxyethyl guanidinium) chloride (PGH), used in humidifier disinfectants, and gestational diabetes mellitus (GDM). We confirmed pregnancy from 2003 to 2017 and identified GDM by linking a cohort of claimants who reported exposure to PHMG/PGH with National Health Insurance Service data. The GDM incidence was calculated, and PHMG/PGH exposure characteristics—exposure status, the humidifier’s distance/location, and exposure duration/hours—were investigated. Logistic regression and mediation analysis were applied using asthma, frequently treated with steroids, as a mediator. Among 521 pregnancies, 38 were identified as GDM, with 2.4% before exposure and 8.9% after exposure. Pregnancies after exposure had a higher odds ratio (OR) for GDM (OR 2.968, 95% CI: 1.004–12.725). A trend of increased GDM risk was observed with longer exposure duration/hours. Additionally, pregnancies after exposure demonstrated total and direct effects on GDM (β = 0.0435, p = 0.036, β = 0.0432, p = 0.030) independent of the indirect effects by asthma. The incidence of GDM was higher after PHMG/PGH exposure compared to before. PHMG/PGH exposure was associated with GDM, independent of asthma. Further research is warranted to confirm these findings in exposed cohorts and to explore the underlying mechanisms. Full article
(This article belongs to the Special Issue Identification of Toxic Effects of Emerging Chemicals throughout the Reproductive Process)
►▼ Show Figures

Figure 1

23 pages, 4216 KiB  
Article
Micro/Nanoplastic Exposure on Placental Health and Adverse Pregnancy Risks: Novel Assessment System Based upon Targeted Risk Assessment Environmental Chemicals Strategy
by Danyang Wan, Yujie Liu, Qianjing Chang, Zhaofeng Liu, Qing Wang, Rui Niu, Beibei Gao, Quanquan Guan and Yankai Xia
Toxics 2024, 12(8), 553; https://doi.org/10.3390/toxics12080553 - 30 Jul 2024
Cited by 1 | Viewed by 1389
Abstract
Micro/nanoplastics (MNPs), as emerging pollutants, have been detected in both the maternal and fetal sides of the placenta in pregnant women, and their reproductive toxicity has been demonstrated in in vivo and in vitro experimental models. The Targeted Risk Assessment of Environmental Chemicals [...] Read more.
Micro/nanoplastics (MNPs), as emerging pollutants, have been detected in both the maternal and fetal sides of the placenta in pregnant women, and their reproductive toxicity has been demonstrated in in vivo and in vitro experimental models. The Targeted Risk Assessment of Environmental Chemicals (TRAEC) strategy has been innovatively devised to facilitate valid risk assessment, encompassing a comprehensive evaluation of reliability, correlation, outcome fitness, and integrity across four dimensions based on the included published evidence and our own findings. This study serves as an application case of TRAEC, with 40 items of research evidence on the toxicity of MNPs to the placenta, which were rigorously screened and incorporated into the final scoring system. The final score for this TRAEC case study is 5.63, suggesting a moderate-to-low risk of reproductive toxicity associated with MNPs in the placenta, which may potentially increase with decreasing particle size. It is essential to emphasize that the findings also report original data from assays indicating that exposure to high-dose groups (100 μg/mL, 200 μg/mL) of 50 nm and 200 nm polystyrene nanoplastics (PS-NPs) induces HTR8/SVneo cell cycle arrest and cell apoptosis, which lead to reproductive toxicity in the placenta by disrupting mitochondrial function. Overall, this study employed the TRAEC strategy to provide comprehensive insight into the potential reproductive health effects of ubiquitous MNPs. Full article
(This article belongs to the Special Issue Identification of Toxic Effects of Emerging Chemicals throughout the Reproductive Process)
►▼ Show Figures

Figure 1

13 pages, 9051 KiB  
Article
The Male Reproductive Toxicity Caused by 2-Naphthylamine Was Related to Testicular Immunity Disorders
by Pengyuan Dai, Mengqian Ding, Jingyan Yu, Yuan Gao, Miaomiao Wang, Jie Ling, Shijue Dong, Xiaoning Zhang, Xuhui Zeng and Xiaoli Sun
Toxics 2024, 12(5), 342; https://doi.org/10.3390/toxics12050342 - 7 May 2024
Viewed by 1279
Abstract
2-naphthylamine (NAP) was classified as a group I carcinogen associated with bladder cancer. The daily exposure is mostly from cigarette and E-cigarette smoke. NAP can lead to testicular atrophy and interstitial tissue hyperplasia; however, the outcomes of NAP treatment on spermatogenesis and the [...] Read more.
2-naphthylamine (NAP) was classified as a group I carcinogen associated with bladder cancer. The daily exposure is mostly from cigarette and E-cigarette smoke. NAP can lead to testicular atrophy and interstitial tissue hyperplasia; however, the outcomes of NAP treatment on spermatogenesis and the associated mechanisms have not been reported. The study aimed to investigate the effect of NAP on spermatogenesis and sperm physiologic functions after being persistently exposed to NAP at 5, 20, and 40 mg/kg for 35 days. We found that sperm motility, progressive motility, sperm average path velocity, and straight-line velocity declined remarkably in the NAP (40 mg/kg) treated group, and the sperm deformation rate rose upon NAP administration. The testis immunity- and lipid metabolism-associated processes were enriched from RNA-sequence profiling. Plvap, Ccr7, Foxn1, Trim29, Sirpb1c, Cfd, and Lpar4 involved in testis immunity and Pnliprp1 that inhibit triglyceride and cholesterol absorption were confirmed to rise dramatically in the NAP-exposed group. The increased total cholesterol and CD68 levels were observed in the testis from the NAP-exposed group. Gpx5, serving as an antioxidant in sperm plasma, and Semg1, which contributes to sperm progressive motility, were both down-regulated. We concluded that the short-term exposure to NAP caused reproductive toxicity, primarily due to the inflammatory abnormality in the testis. Full article
(This article belongs to the Special Issue Identification of Toxic Effects of Emerging Chemicals throughout the Reproductive Process)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop