Closing the Fluorine Gap: From the Analytical Technologies to Fate Modeling

A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 5306

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
1. Faculty of Science, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park, 904 GD Amsterdam, The Netherlands
2. Queensland Alliance of Environmental Health Sciences, The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia
Interests: chemicals of emerging concern (CECs); non-target analysis (NTA); high resolution mass spectrometry (HRMS); computational mass spectrometry; algorithm development; advanced statistics

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Guest Editor
Queensland Alliance for Environmental Health Sciences (QAEHS), University of Queensland, Brisbane, Australia
Interests: chemicals of emerging concern; analytical chemistry; non target analysis; environmental fate and transport; sampling techniques

Special Issue Information

Dear Colleagues,

Per- and polyfluoroalkyl substances (PFASs) are a family of chemicals of emerging concern that consist of at least 5000 unique chemical structures. The US Environmental Protection Agency has listed around 8000 potential PFASs, from which a large number are structurally unknown. Due to their structural diversity, they cover a wide range of physiochemical properties, environmental fates, and toxicities. Consequently, they are considered an extremely challenging family of chemicals to measure and model. Additionally, recent studies have shown their potential negative impact on human and environmental health.

This Special Issue focuses on the latest analytical developments and the application of such tools for unravelling the complexity of PFASs and thus closing the fluorine knowledge gap. Manuscripts are expected to cover (but not limited to) topics related to the development of novel analytical approaches, sample collection, sample preparation, and data processing tools. Studies on the environmental occurrence, fate, and modeling of PFAS are also welcome. This Special Issue welcomes the submission of original research papers, review papers, and short communications. 

Dr. Saer Samanipour
Dr. Sarit L. Kaserzon
Guest Editors

Manuscript Submission Information

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Keywords

  • PFAS
  • analytical chemistry
  • high-resolution mass spectrometry
  • fate modeling
  • non-targeted analysis

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Published Papers (1 paper)

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Research

12 pages, 1267 KiB  
Article
Early Warnings by Liver Organoids on Short- and Long-Chain PFAS Toxicity
by Stefano Palazzolo, Isabella Caligiuri, Andrea Augusto Sfriso, Matteo Mauceri, Rossella Rotondo, Davide Campagnol, Vincenzo Canzonieri and Flavio Rizzolio
Toxics 2022, 10(2), 91; https://doi.org/10.3390/toxics10020091 - 18 Feb 2022
Cited by 21 | Viewed by 4757
Abstract
Short-chain per-fluoroalkyl substances (PFAS) have replaced long-chains in many applications, however the toxicity and its mode of action and interactions due to the large number of these compounds and their mixtures is still poorly understood. The paper aims to compare the effects on [...] Read more.
Short-chain per-fluoroalkyl substances (PFAS) have replaced long-chains in many applications, however the toxicity and its mode of action and interactions due to the large number of these compounds and their mixtures is still poorly understood. The paper aims to compare the effects on mouse liver organoids (target organ for bioaccumulation) of two long-chain PFAS (perfluorooctane sulfonate -PFOS-, perfluorooctanoic acid -PFOA) and two short-chain PFAS commonly utilized in the industry (heptafluorobutyric acid -HFBA-, Pentafluoropropionic anhydride-PFPA) to identify the mode of action of these classes of contaminants. Cytomorphological aberrations and ALT/GDH enzyme disruption were identified but no acute toxicity endpoint neither apoptosis was detected by the two tested short-chain PFAS. After cytomorphological analysis, it is evident that short-chain PFAS affected organoid morphology inducing a reduction of cytostructural complexity and aberrant cytological features. Conversely, EC50 values of 670 ± 30 µM and 895 ± 7 µM were measured for PFOS and PFOA, respectively, together with strong ALT/GDH enzyme disruption, caspase 3 and 7 apoptosis activation and deep loss of architectural complexity of organoids in the range of 500–1000 µM. Eventually, biochemical markers and histology analysis confirmed the sensitivity of organoid tests that could be used as a fast and reproducible platform to test many PFAS and mixtures saving time and at low cost in comparison with in vivo tests. Organoids testing could be introduced as an innovative platform to assess the toxicity to fast recognize potentially dangerous pollutants. Full article
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