Recent Research into Oxidative Stress and Toxicity of Chemicals and Medicinal Plants

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Drugs Toxicity".

Deadline for manuscript submissions: 27 February 2025 | Viewed by 777

Special Issue Editors


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Guest Editor
Oxidative Stress Research Lab, Institute of Biological Sciences, Federal University of Pará–UFPA, Belém, PA, Brazil
Interests: oxidative stress; nitric oxide; antioxidants; free radicals; malaria; Amazon medicinal plants

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Guest Editor
Faculty of Pharmacy, Institute of Health Sciences, Federal University of Pará–UFPA, Belém, PA, Brazil
Interests: leishmaniasis; malaria; Amazon natural products; neglected diseases; pharmaceutical assistance; toxicity assessment

Special Issue Information

Dear Colleagues,

Although the use of plants for medicinal purposes is as old as the history of humanity, we have not yet been able to systematically evaluate the potential uses of our planet's biodiversity to identify its numerous applications for improving the quality of life, especially for the development of new natural medicines that present the desired therapeutic effect but have no side effects often found in synthetic drugs. In addition, especially among antibiotics and antiparasitics, resistance to conventional drugs has become increasingly frequent, which drives us in the search for new therapeutic alternatives. However, there is limited scientific knowledge about several species with medicinal purposes and even less knowledge about their mechanisms of action and, especially, about the potential toxic effects of their use. Thus, this Special Issue is intended to present innovative research on the use of new medicinal plants and the involvement of oxidative stress in the underlying mechanisms of toxicity induced by chemicals or medicinal plants.

We invite submissions that cover, but are not limited to, the following topics:

  • New plants with medicinal potential;
  • Mechanisms of action of medicinal plants, mainly involving antioxidants or oxidative stress;
  • Therapeutic use of synthetic chemicals derived from plants or substances isolated from plants;
  • Acute, semi-chronic, or chronic toxicity studies of medicinal plants, synthetic chemical substances derived from plants, or substances isolated from plants.

Prof. Dr. Sandro Percário
Dr. Maria Fâni Dolabela
Guest Editors

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Keywords

  • free radicals
  • oxidative stress
  • antioxidants
  • medicinal plants
  • natural products
  • chemical toxicity
  • plant toxicity

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Published Papers (1 paper)

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Research

14 pages, 3068 KiB  
Article
Exploration of Secondary Metabolites in Platostoma menthoides (L.) Using Ethyl Acetate Extract and Its Antibacterial, Antioxidant, and Larvicidal Activities
by Pavithra Senthilkumar, Subbu Thavamurugan, Aravinth Annamalai, Prabhu Kolandhasamy, Vasanthy Muthunarayanan, Nandhini Selvaraj, Lakshmiprabha Azhagiyamanavalan and Ramachandran Vinayagam
Toxics 2025, 13(1), 51; https://doi.org/10.3390/toxics13010051 - 11 Jan 2025
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Abstract
Recently, there has been a growing demand for plant-based products to treat a range of health conditions. Platostoma menthoides (L.), a member of the Lamiaceae family, is widely known for its versatile therapeutic properties. The primary aim of this study is to analyze [...] Read more.
Recently, there has been a growing demand for plant-based products to treat a range of health conditions. Platostoma menthoides (L.), a member of the Lamiaceae family, is widely known for its versatile therapeutic properties. The primary aim of this study is to analyze and identify the secondary metabolites found in the extract of P. menthoides obtained using ethyl acetate and to assess its antioxidant, antimicrobial, and mosquito larvicidal properties for the first time. For the chemical profiling, a GC–MS analysis of the extract was conducted, and it showed the presence of various phytoconstituents, and the FT-IR spectrum revealed the functional groups associated with them. The quantitative phytochemical estimations revealed values of 34.87 ± 0.53 mg of GAE equivalents/g and 22.19 ± 1.11 mg of QUE equivalents/g, respectively, for total phenolic and flavonoid content. The biological studies of P. menthoides extract showed potent mosquito larvicidal activity against fourth instar larvae of Aedes aegypti at a 100 µg/mL concentration with LC50 and LC90 values of 81.328 and 161.471 µg/mL, respectively. Moreover, the DPPH and FRAP radical scavenging potentials were evaluated, and the results revealed their ability to scavenge the free radicals. The extract also showed higher antibacterial effects against gram-negative bacteria when compared to gram-positive bacteria. All these findings suggest that P. menthoides is a rich source of phytoconstituents with various medicinal applications and can be used as an antioxidant, antibacterial, and mosquito-larvicidal agent. Full article
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