Interactions across Different Exposures and Life-Stages in Exposome Research

Dear colleagues,

The concept of the exposome has broadened the range of exposures that must be considered for their possible role in the pathogenesis of human disease and has highlighted the importance of the effects that such exposures, occurring at different life-stages, exert in the determination of the overall risk of disease. An additional major consideration highlighted by the exposome concept concerns the way in which different exposures, whether concurrent or occurring at different life-stages, may interact and jointly modify the overall risk of disease.

Thanks to these innovative ideas, the exposome has served as a stimulus for significant advances in various areas of public and environmental health research, including exposure assessment, in utero and early-life exposures and downstream effects, as well as novel statistical tools for the analysis of highly complex datasets. On the other hand, the problem of potential interactions between the multiplicity of exposures has been less extensively studied and still represents a largely unexplored practical and theoretical challenge. The identification of such interactions in the complexity of exposures or co-exposures, often highly correlated, that are often present in high-dimensional datasets of population health, warrants the use of specialized study designs and advanced algorithms for statistical analyses. Environment-wide association studies and their exposomic tools represent novel approaches to tackle societal challenges in environmental health, toxicology, and precision medicine. For this Special Issue, we wish to invite manuscripts of all types (original studies, reviews, perspectives, etc.) that address all of the above aspects and the utility of the exposome’s methodological framework, with a particular focus on the interactions between exposures and across different life-stages.

Prof. Dr. Soterios A. Kyrtopoulos
Dr. Konstantinos C. Makris
Guest Editors

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• mixture toxicology
• in utero exposures
• epigenetic memory
• delayed effects
• early-life exposures
• nutrient deficiencies
• social stress
• environment-wide association studies
• acquired susceptibility
• biomarkers