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Toxins
Special Issues
Snake Bite and Related Injury
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Snake Bite and Related Injury

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 2165

Special Issue Editor

Dr. Matteo Riccardo Di Nicola

E-Mail Website
Guest Editor
Unit of Dermatology, IRCCS San Raffaele Hospital, 20132 Milan, Italy
Interests: reptiles; amphibians; herpetology; snakes; Italian wildlife
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The present Special Issue focuses on the diverse topic of snake bites and related injuries, addressing incidents involving front-fanged snakes such as Viperidae, Elapidae, and Atractaspidae, as well as non-front-fanged colubroid (NFFC) snakes from around the world. The Special Issue welcomes research articles, reviews, short notes, and case reports that explore snake bite incidents in both human and veterinary contexts, including pets such as dogs and cats, as well as livestock. Contributions examining epidemiological aspects, as well as societal perceptions of snakes and snake bites, are also encouraged. By featuring a range of studies, this issue aims to enhance the understanding of snake bite management, treatment strategies, prevention measures, and public health implications.

Dr. Matteo Riccardo Di Nicola
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • snakebite
  • front-fanged snakes
  • Viperidae
  • Elapidae
  • Atractaspidae
  • non-front fanged
  • NFFC
  • epidemiology
  • veterinary toxicology

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Published Papers (2 papers)

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Research

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20 pages, 3023 KiB  
Article
Snake Venom Pharmacokinetics and Acute Toxic Outcomes Following Daboia siamensis Envenoming: Experimental and Clinical Correlations
by Sethapong Lertsakulbunlue, Wipapan Khimmaktong, Orawan Khow, Wittawat Chantkran, Jureeporn Noiphrom, Kanyanat Promruangreang, Lawan Chanhome and Janeyuth Chaisakul
Toxins 2025, 17(1), 10; https://doi.org/10.3390/toxins17010010 - 29 Dec 2024
Viewed by 1050
Abstract
An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes of envenoming and developing therapeutic approaches to the treatment of envenoming, especially regarding the timing and optimal dosage of antivenom administration. Daboia siamensis (Eastern Russell’s viper) envenoming causes systemic coagulopathy and [...] Read more.
An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes of envenoming and developing therapeutic approaches to the treatment of envenoming, especially regarding the timing and optimal dosage of antivenom administration. Daboia siamensis (Eastern Russell’s viper) envenoming causes systemic coagulopathy and severe hemorrhage including acute kidney injury. These toxic outcomes can be diminished by the administration of high quantities of Russell’s viper antivenom. This study aimed to determine the correlation between the clinical profiles of D. siamensis envenomed patients and experimental data by measuring plasma venom concentration and conducting histopathological analyses of heart, kidney, and liver tissues in rats 6 h after experimental D. siamensis envenomation. Intramuscular (i.m.) administration of D. siamensis venom to anesthetized rats (200 µg/kg) resulted in a rapid absorption of venom which reached a peak concentration at 60 min before declining and then plateauing. Urine samples detected 209.3 ± 21.6 ng/mL of D. siamensis venom following i.m. administration at 6 h. Histopathological studies showed morphological changes in heart, kidney, and liver tissues following 3 h experimental envenoming and exhibited a higher degree of severity at 6 h. A retrospective study of the clinical profile and laboratory examination of Russell’s viper envenomed patients in Central Thailand was also evaluated, showing that systemic coagulopathy and local effects were commonly observed in the early stage of D. siamensis envenoming. An abnormal increase in creatinine levels was found in 13.6% of the population. Early administration of specific antivenom within 1–2 h following envenoming is highly recommended to prevent life-threatening outcomes such as severe coagulation and acute kidney injury. Full article
(This article belongs to the Special Issue Snake Bite and Related Injury)
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Review

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13 pages, 6168 KiB  
Review
Clinical Characteristics of Snakebite Envenomings in Taiwan
by Yan-Chiao Mao, Po-Yu Liu, Kuo-Lung Lai, Yi Luo, Kuang-Ting Chen and Chih-Sheng Lai
Toxins 2025, 17(1), 14; https://doi.org/10.3390/toxins17010014 - 30 Dec 2024
Viewed by 789
Abstract
Snakebite envenomings continue to represent a major public health concern in Taiwan because of the presence of various venomous snakes whose habitats intersect with human activities. This review provides a comprehensive analysis of the clinical characteristics, complications, and management strategies associated with snakebite [...] Read more.
Snakebite envenomings continue to represent a major public health concern in Taiwan because of the presence of various venomous snakes whose habitats intersect with human activities. This review provides a comprehensive analysis of the clinical characteristics, complications, and management strategies associated with snakebite envenomings in Taiwan. Taiwan is inhabited by six principal venomous snakes: Trimeresurus stejnegeri stejnegeri, Protobothrops mucrosquamatus, Deinagkistrodon acutus, Daboia siamensis, Naja atra, and Bungarus multicinctus, each presenting distinct clinical challenges. The clinical manifestations vary from local symptoms such as pain, swelling, and necrosis to systemic complications including neurotoxicity, coagulopathy, and organ failure, depending on the species. Notable complications arising from these snakebite envenomings include necrotizing soft tissue infection, compartment syndrome, respiratory failure, and acute kidney injury, often necessitating intensive medical interventions. This review highlights the critical importance of early diagnosis, the prompt administration of antivenoms, and multidisciplinary care to improve patient outcomes and reduce healthcare costs. Future research is encouraged to enhance treatment efficacy, improve public awareness, and develop targeted prevention strategies. By identifying gaps in current knowledge and practice, this work contributes to the global literature on envenoming management and serves as a foundation for advancing clinical protocols and reducing snakebite-related morbidity and mortality in Taiwan. Full article
(This article belongs to the Special Issue Snake Bite and Related Injury)
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